Results 61 to 70 of about 11,685 (174)
Recent Advances in Amphipathic Peptidomimetics as Antimicrobial Agents to Combat Drug Resistance
MoleculesThe development of antimicrobial drugs with novel structures and clear mechanisms of action that are active against drug-resistant bacteria has become an urgent need of safeguarding human health due to the rise of bacterial drug resistance. The discovery
Ma Su, Yongxiang Su
doaj +1 more source
Cancer pain: current practice and emerging targets
British Journal of Pharmacology, EarlyView.Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye +5 more
wiley +1 more source
, 2012 2-D chemical representations of the 12 peptidomimetics that form our dataset are shown. IC50 value represents the experimental binding affinity of each peptidomimetic derived using fluorescence polarization and N represents the number of rotatable bonds ...
Lydia E. Kavraki (111882) +2 more
core +1 more source
Design and Synthesis of Novel Peptidomimetics for Cancer Immunotherapy [PDF]
, 2020 Tumor cells benefit from some certain signals, which are referred to as “immune checkpoints”, to escape immune-mediated destruction. With that in mind, it is believed that the blockade of these points, such as programmed cell death Ligand-1 (PD-L1) and ...
Zeynep, Tuğay +11 more
core +1 more source
European Journal of Medicinal Chemistry ReportsThe design of pharmaceutically relevant compounds that mimic bioactive peptides or secondary structure elements in proteins is an important task in medicinal chemistry. Over time, various chemical strategies have been developed to convert natural peptide
Atsushi Yoshimori, Jürgen Bajorath
doaj +1 more source
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Cerebral ischaemia is a leading cause of death in older adults and imposes a substantial global economic burden. Recent studies indicate that inhibiting the Gαs‐coupled EP2 receptor reduces ischaemic brain injury by modulating neuroinflammation.
Zhen Jin +7 more
wiley +1 more source
One-pot synthesis of new class of dithiocarbonate-tethered peptidomimetics
, 2015 A simple and an efficient one-pot protocol for the synthesis of a new class of dithiocarbonate-tethered peptidomimetics and neo-glycosylated amino acids have been developed.
Krishnamurthy, M. +3 more
core +1 more source
Inhibitory Activity of Red Panda Islet Amyloid Polypeptide on Human IAPP Aggregation
Journal of Peptide Science, Volume 32, Issue 12, December 2026.The figure shows the comparison of (a) human islet amyloid polypeptide (hIAPP) self‐assembling into a fibril structure and (b) a model of hIAPP self‐assembling in the presence of red panda islet amyloid polypeptide (IAPP). The figure was produced from PDB file 6Y1A using Swiss PDB viewer software.
Lauren Phillips +5 more
wiley +1 more source
One-Pot High-Throughput Synthesis of β-Turn Cyclic Peptidomimetics via “Volatilizable” Supports
, 2016 A promising method for the high-throughput synthesis of linear C-hydroxyalkylamido peptidomimetics and β-turn cyclic peptidomimetics via “volatilizable” aminoalkyl functionalized silica gels is presented. Boc amino acids and carboxylic acids were coupled
Yangmei Li (322348) +3 more
core +1 more source
MyD88‐Family Adaptors: Compartmentalised Signalling and Non‐Immune Functions
Immunology, Volume 179, Issue 4, Page 537-553, December 2026.MyD88‐family adaptors coordinate receptor‐ and compartment‐specific innate immune signalling across plasma membrane and endosomal pathways. At the plasma membrane, TIRAP/MAL supports MyD88‐dependent signalling downstream of TLR2 and TLR4, whereas endosomal TLR7, TLR8 and TLR9 recruit MyD88 directly.
Seshu Vardhan Pothabathula +6 more
wiley +1 more source