Results 61 to 70 of about 11,458 (225)

12 peptidomimetics.

, 2012
2-D chemical representations of the 12 peptidomimetics that form our dataset are shown. IC50 value represents the experimental binding affinity of each peptidomimetic derived using fluorescence polarization and N represents the number of rotatable bonds ...
Lydia E. Kavraki (111882), Ankur Dhanik (111877), John S. McMurray (111879)   +2 more
core   +1 more source

Polyamide Backbone Modified Cell Targeting and Penetrating Peptides in Cancer Detection and Treatment

Frontiers in Chemistry, 2020
Cell penetrating and targeting peptides (CPPs and CTPs) encompass an important class of biochemically active peptides owning the capabilities of targeting and translocating within selected cell types.
Sunil S. Shah, Nelson Casanova, Gina Antuono, David Sabatino   +3 more
doaj   +1 more source

Multicomponent synthesis and photophysical study of novel α,β-unsaturated carbonyl depsipeptides and peptoids

Frontiers in Chemistry, 2023
Multicomponent reactions were performed to develop novel α,β-unsaturated carbonyl depsipeptides and peptoids incorporating various chromophores such as cinnamic, coumarin, and quinolines.
Ricelia González, Juliana Murillo-López, Walter Rabanal-León, Luis Prent-Peñaloza, Odette Concepción, Pedro Olivares, Yorley Duarte, Alexander F. de la Torre, Margarita Gutiérrez, Julio Caballero   +9 more
doaj   +1 more source

Synthetic route for the tripeptide peptidomimetics.

, 2015
Synthetic route for the tripeptide peptidomimetics.
Stephanie Tay (777269), Róisín M. McMahon (777270), Wilko Duprez (485319), Martin J. Stoermer (777268), David P. Fairlie (180958), Prabhakar Bachu (777267), Jennifer L. Martin (80694)   +6 more
core   +1 more source

Different behavior of cyclic RGD peptidomimetics versus a5b1 and aVb3 integrin-rich cancer cells: NMR and computational analysis

, 2016
Integrins are a family of adhesion molecules which regulate diverse cell functions. Recent studies provide evidence of the importance of Arg-Gly-Asp (RGD) binding integrins in tumor angiogenesis, progression and metastasis, suggesting the use of dual ...
D. Arosio, F. Vasile, M. Civera, L. Belvisi, C. Gennari, U. Piarulli, D. Potenza   +6 more
core   +1 more source

Synthesis of acylhydrazino-peptomers, a new class of peptidomimetics, by consecutive Ugi and hydrazino-Ugi reactions

Beilstein Journal of Organic Chemistry, 2016
Herein we describe a versatile approach for the synthesis of acylhydrazino-peptomers, a new class of peptidomimetics. The key idea in this approach is based on a simple route using a one-pot hydrazino-Ugi four-component reaction followed by a ...
Angélica de Fátima S. Barreto, Veronica Alves dos Santos, Carlos Kleber Z. Andrade   +2 more
doaj   +1 more source

Recent Advances in Amphipathic Peptidomimetics as Antimicrobial Agents to Combat Drug Resistance

Molecules
The development of antimicrobial drugs with novel structures and clear mechanisms of action that are active against drug-resistant bacteria has become an urgent need of safeguarding human health due to the rise of bacterial drug resistance. The discovery
Ma Su, Yongxiang Su
doaj   +1 more source

Direct conversion of peptides into diverse peptidomimetics using a transformer-based chemical language model

European Journal of Medicinal Chemistry Reports
The design of pharmaceutically relevant compounds that mimic bioactive peptides or secondary structure elements in proteins is an important task in medicinal chemistry. Over time, various chemical strategies have been developed to convert natural peptide
Atsushi Yoshimori, Jürgen Bajorath
doaj   +1 more source

Development of Antiviral Peptidomimetics

, 2023
Protein-protein interactions (PPIs) are essential for biological processes and are associated with a number of diseases, including cancer, infectious diseases, and neurodegenerative diseases.
Xue, Songyi
core  

Solid-Phase Synthesis of Amine/Carboxyl Substituted Prolines and Proline Homologues: Scope and Limitations

Molecules, 2016
A solid-phase procedure is used to synthesize racemic peptidomimetics based on the fundamental peptide unit. The peptidomimetics are constructed around proline or proline homologues variably substituted at the amine and carbonyl sites.
Ziniu Zhou, William L. Scott, Martin J. O’Donnell   +2 more
doaj   +1 more source