Results 61 to 70 of about 10,137 (233)
, 2012 2-D chemical representations of the 12 peptidomimetics that form our dataset are shown. IC50 value represents the experimental binding affinity of each peptidomimetic derived using fluorescence polarization and N represents the number of rotatable bonds ...
Lydia E. Kavraki (111882) +2 more
core +1 more source
Beilstein Journal of Organic Chemistry, 2016 Herein we describe a versatile approach for the synthesis of acylhydrazino-peptomers, a new class of peptidomimetics. The key idea in this approach is based on a simple route using a one-pot hydrazino-Ugi four-component reaction followed by a ...
Angélica de Fátima S. Barreto +2 more
doaj +1 more source
Chemistry – A European Journal, EarlyView.A phosphorescent iridium(III) complex has been prepared with a 6‐hydrazinonicotinic acid (HYNIC) ligand tethered to a lysine‐ureido‐glutamatic acid pharmacophore, which binds to an enzyme, called prostate‐specific membrane antigen (PSMA), which is overexpressed in prostate cancer.
La'El Kimchi +6 more
wiley +1 more source
Peptidomimetic toolbox for drug discovery
Chemical Society Reviews, 2020 Local modifications, secondary structure mimetics and global restrictions are useful synthetic tools for peptidomimetic design.
Lenci, Elena, Trabocchi, Andrea
openaire +2 more sources
Development of Peptidomimetics Targeting IAPs [PDF]
International Journal of Peptide Research and Therapeutics, 2006 Inhibitor of apoptosis proteins (IAPs) such as XIAP subvert apoptosis by binding and inhibiting caspases. Because occupation of the XIAP BIR3 peptide binding pocket by Smac abolishes the XIAP-caspase 9 interaction, it is a proapoptotic event of great therapeutic interest. An assay for pocket binding was developed based on the displacement of Smac 7-mer
Sharma, Sushil K. +2 more
openaire +2 more sources
C-Terminal Extended Hexapeptides as Potent Inhibitors of the NS2B-NS3 Protease of the ZIKA Virus
Frontiers in Medicine, 2022 The Zika virus (ZIKV) protease is an attractive drug target for the design of novel inhibitors to control the ZIKV infection. As the protease substrate-binding site contains acidic residues, inhibitors with basic residues can be beneficial for the ...
Suyash Pant, Nihar R. Jena
doaj +1 more source
Dynamic Control of Nucleic Acids Self‐Assembly and Expression Using Photoswitches
Chemistry – A European Journal, EarlyView.We review here the recent progress made in the design of molecular photoswitches, and highlight their implementation for the dynamic control over nucleic acids self‐assembly and expression. ABSTRACT Synthetic nucleic acids have become readily available and now constitute versatile building blocks in materials science—where they can be used to engineer ...
Noemí Nogal +4 more
wiley +1 more source
Synthetic route for the tripeptide peptidomimetics.
, 2015 Synthetic route for the tripeptide peptidomimetics.
Stephanie Tay (777269) +6 more
core +1 more source
Recent Advances in Amphipathic Peptidomimetics as Antimicrobial Agents to Combat Drug Resistance
MoleculesThe development of antimicrobial drugs with novel structures and clear mechanisms of action that are active against drug-resistant bacteria has become an urgent need of safeguarding human health due to the rise of bacterial drug resistance. The discovery
Ma Su, Yongxiang Su
doaj +1 more source
Non-Conventional Peptide Self-Assembly into a Conductive Supramolecular Rope
Nanomaterials, 2023 Structures composed of alternating α and β amino acids can give rise to peculiar secondary structural motifs, which could self-assemble into complex structures of controlled geometries.
Nicola Forlano +7 more
doaj +1 more source