Results 71 to 80 of about 11,458 (225)
Synthesis of thioureido peptidomimetics employing alkyl azides and dithiocarbamates
, 2018 An unprecedented approach for the assembly of thioureido peptidomimetics is developed employing alkyl azides and dithiocarbamates. Dithiocarbamates react with alkyl azides with the liberation of N2 and elemental sulfur thereby leading to thiourea in a ...
Vishwanatha, T.M. +4 more
core +1 more source
Synthesis of peptidomimetics comprising hydrazino - derivatives of amino acides [PDF]
, 2016 Peptidi i proteini imaju ključnu ulogu u nizu bioloških i fizioloških procesa; međutim, njihova primjena kao terapeutika je ograničena slabom stabilnošću i biodostupnošću.
Suć, Josipa
core +3 more sources
Synthesis of Biologically Active Arginine Derivatives Derived from Salicylamide
Chemistry ProceedingsPeptidomimetics represent a promising group of biologically active compounds with broad therapeutic potential that mimic naturally occurring peptides while overcoming their limitations. In this study, novel peptidomimetics derived from salicylic acid and
Martin Šanda, Aleš Imramovský
doaj +1 more source
Chemistry – A European Journal, EarlyView.A modular, de novo α/β‐peptide design strategy allows fine‐tuning of ligand properties, resulting in multivalent ligands that simultaneously target separate binding sites on the protein surface. ABSTRACT Protein‐protein interactions that regulate gene expression in the nucleus are increasingly recognized as potential therapeutic targets but present ...
Márk V. Tresztián +4 more
wiley +1 more source
Chemistry – A European Journal, EarlyView.Integrin αVβ3‐targeting small‐molecule drug conjugates (SMDCs) were synthesized by conjugating a cryptophycin payload through a neutrophil elastase‐cleavable NPV‐PABC linker. RGD peptidomimetic and linker epimers served as controls for targeting and enzymatic cleavage, and the resulting conjugates displayed subnanomolar cytotoxicity in vitro.
Dominic Seißenschmidt +3 more
wiley +1 more source
One-pot synthesis of new class of dithiocarbonate-tethered peptidomimetics
, 2015 A simple and an efficient one-pot protocol for the synthesis of a new class of dithiocarbonate-tethered peptidomimetics and neo-glycosylated amino acids have been developed.
Krishnamurthy, M. +3 more
core +1 more source
Cyclic Octamer Peptoids: Simplified Isosters of Bioactive Fungal Cyclodepsipeptides
Molecules, 2018 Cyclic peptoids have recently emerged as an important class of bioactive scaffolds with unique conformational properties and excellent metabolic stabilities.
Assunta D’Amato +5 more
doaj +1 more source
Chemistry – A European Journal, EarlyView.Hybrid macrocyclic peptides unite genetically encoded peptide libraries with the structural complexity of synthetic small molecules. This Review critically analyzes phage‐compatible cyclization and diversification chemistries, highlights emerging opportunities beyond traditional cysteine‐based approaches, and outlines how future advances may enable the
Titia Rixt Oppewal, Clemens Mayer
wiley +1 more source
Cell adhesive PET membranes by surface grafting of RGD peptidomimetics.
, 2005 A non-peptide mimic of the Arg-Gly Asp (RGD) active sequence of adhesive proteins (such as vitronectin) has been equipped with two different spacer-arms for surface anchorage.
Biltresse, Stéphane +2 more
core +1 more source
Therapeutic peptides and peptidomimetics
Current Opinion in Biotechnology, 1997 Peptidomimetics are one set of probes used in the transition pathway of small molecule drug design. Cyclization of the peptide backbone and its modification with aromatic residues constitutes an effective approach to mimetic drug design and circumvents obstacles associated with delivery and formulation of peptides and peptidomimetics. In the past year,
T, Kieber-Emmons, R, Murali, M I, Greene
openaire +2 more sources