Results 71 to 80 of about 11,685 (174)

Solid-Phase Synthesis of Amine/Carboxyl Substituted Prolines and Proline Homologues: Scope and Limitations

Molecules, 2016
A solid-phase procedure is used to synthesize racemic peptidomimetics based on the fundamental peptide unit. The peptidomimetics are constructed around proline or proline homologues variably substituted at the amine and carbonyl sites.
Ziniu Zhou, William L. Scott, Martin J. O’Donnell   +2 more
doaj   +1 more source

Halogenated Tryptophans Improve Integrin αVβ6 Affinity of Cyclic RGD Peptides and Provide Handles for Late‐Stage Derivatization

Chemistry – A European Journal, Volume 32, Issue 41, 3 November 2026.
Lighting up αVβ6: Halotryptophan engineering converts an RGD scaffold into a modular αVβ6 ligand platform, enabling picomolar affinity and late‐stage functionalization. The resulting probes combine high selectivity with fluorescence for FACS and tumor imaging.
Beate Nachtigall, Caroline Brinkmann, Jana Langosch, Anke Nieß, Norbert Sewald   +4 more
wiley   +1 more source

Backbone Steric Constraints Underlie High Passive Membrane Permeability of N‐Alkyl Peptides

Angewandte Chemie, Volume 138, Issue 41, 5 October 2026.
Beyond amide hydrogen removal, steric constraints encoded in N/Cα‐dually substituted backbones are uncovered as a key determinant of passive membrane permeability in N‐alkyl peptides. These constraints restrict conformational freedom and sterically limit backbone hydration during membrane permeation.
Ayumi Inayoshi, Mariko Akiba, Marin Yokomine, Masatake Sugita, Koji Umezawa, Yuto Hirota, Yutaka Akiyama, Jumpei Morimoto, Shinsuke Sando   +8 more
wiley   +2 more sources

Synthesis of Biologically Active Arginine Derivatives Derived from Salicylamide

Chemistry Proceedings
Peptidomimetics represent a promising group of biologically active compounds with broad therapeutic potential that mimic naturally occurring peptides while overcoming their limitations. In this study, novel peptidomimetics derived from salicylic acid and
Martin Šanda, Aleš Imramovský
doaj   +1 more source

Retro Hydrazino-azapeptoids as Peptidomimetics of Proteasome Inhibitors

, 2016
Several groups of proteasome inhibitors are widely used to study the role of the ubiquin proteasome pathway in various cellular processes or as anticancer drugs. Peptidomimetics have been developed to circumvent problems inherent in peptides such as poor
Michèle Baudy-Floc'h (301048), Sandrine Aubin (2695684), Yannick Arlot-Bonnemains (415045), Bénédicte Martin (2441965), Jean-Guy Delcros (421326)   +4 more
core   +1 more source

Peptidomimetics in silico

, 2020
Endogenous peptides as part of physiological processes are targets of interest when it comes to finding desirable therapeutics which are able to modulate molecular interactions.  The major limits presented by peptides when they are used as drugs ...
Tomasella Cristina, Pappalardo Matteo, Basile Livia, Floris Matteo, Guccione Salvatore   +4 more
core   +1 more source

Downsizing the Histone H3–H4 Quaternary Structure Into Foldamer Mimetics Yields High‐Affinity and Cell‐Permeable Ligands of ASF1

Angewandte Chemie, Volume 138, Issue 41, 5 October 2026.
We present a foldamer strategy to downsize the histone H3‐H4 quaternary structure into high‐affinity, medium‐sized binders (∼2 kDa) for the histone chaperone ASF1. Our peptide‐oligourea chimeras, designed through structure‐guided optimization and foldamer chemistry, recapitulate the natural H3‐H4 dimer binding mode while demonstrating plasma stability ...
Bo Li, Marie E. Perrin, Emma Maillard, Arthur Vitard, Gwenaëlle Moal, Johanne Mbianda, Christophe André, Magda Teixeira Nunes, Marie Vandamme, Guillaume Pinna, Céline Douat, Emmanuelle Thinon, Raphaël Guerois, Pierre Legrand, Gilles Guichard, Francoise Ochsenbein   +15 more
wiley   +2 more sources

Development of Antiviral Peptidomimetics

, 2023
Protein-protein interactions (PPIs) are essential for biological processes and are associated with a number of diseases, including cancer, infectious diseases, and neurodegenerative diseases.
Xue, Songyi
core  

Bluues2: An enhanced web server for fast and accurate electrostatic analysis of proteins and protein complexes

Protein Science, Volume 35, Issue 11, November 2026.
Abstract Electrostatic interactions play a crucial role in protein structure, stability, and function. We present Bluues2, a significantly enhanced web server for calculating electrostatic properties of proteins using the Generalized Born model. The new version features improved accuracy through refined GB radius calculations using NanoShaper for ...
Damiano Piovesan, Nima Rasekh, Miguel Angel Soler, Walter Rocchia, Gennaro Esposito, Federico Fogolari, Silvio C. E. Tosatto   +6 more
wiley   +1 more source

Peptidomimetics design and characterization: Bridging experimental and computer-based approaches

Peptidomimetics, designed to mimic peptide biological activity with more drug-like properties, are increasingly pivotal in medicinal chemistry. They offer enhanced systemic delivery, cell penetration, target specificity, and protection against peptidases
Samuele Di Cristofano, Rexha, Jesmina, Borsello, Tiziana, Gloria Venturini, Tiziana Borsello, Borgognoni, Noemi, Noemi Borgognoni, Di Cristofano, Samuele, Raimondo, Domenico, Romagnoli, Alice, Alice Romagnoli, Jesmina Rexha, Nunzio Perta, Daniele Di Marino., Pignotti, Francesco, Di Marino, Daniele, Francesco Pignotti, Perta, Nunzio, Domenico Raimondo, Daniele Di Marino, Venturini, Gloria   +20 more
core   +1 more source