The interplay between viral molecular mimicry and host chromatin dynamics [PDF]
Nucleus, 2023 Molecular mimicry is a commonly used mechanism by viruses to manipulate host cellular machinery and coordinate their life cycles. While histone mimicry is well studied, viruses also employ other mimicry strategies to affect chromatin dynamics.
Shumin Xiao +3 more
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Molecular Mimicry and Uveitis [PDF]
Frontiers in Immunology, 2020 Molecular or antigenic mimicry is a term for the similarity of different antigens, which can be confused by the immune system. Antigen recognition by antibodies and T cell receptors is specific, but not restricted to a single antigen.
Gerhild Wildner +1 more
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Identification of potential molecular mimicry in pathogen-host interactions [PDF]
PeerJ, 2023 Pathogens have evolved sophisticated strategies to manipulate host signaling pathways, including the phenomenon of molecular mimicry, where pathogen-derived biomolecules imitate host biomolecules.
Kaylee D. Rich +3 more
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EMoMiS: A pipeline for epitope-based molecular mimicry search in protein structures with potential applications to SARS-CoV-2 [PDF]
Computational and Structural Biotechnology JournalThe Epitope-based Molecular Mimicry Search (EMoMiS) pipeline developed in this study provides a valuable computational tool for predicting molecular mimicry between antigens.
Vitalii Stebliankin +14 more
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Molecular mimicry in the pathogenesis of autoimmune rheumatic diseases [PDF]
Journal of Translational AutoimmunityAutoimmune rheumatic diseases (ARDs) are a heterogeneous group of conditions characterized by excessive and misdirected immune responses against the body's own musculoskeletal tissues.
Michaela Fehringer, Thomas Vogl
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Molecular mimicry as a mechanism of viral immune evasion and autoimmunity [PDF]
Nature CommunicationsMimicry of host protein structures, or ‘molecular mimicry’, is a common mechanism employed by viruses to evade the host’s immune system. Short linear amino acid (AA) molecular mimics can elicit cross-reactive antibodies and T cells from the host, but the
Cole Maguire +7 more
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Hepatitis C Virus and Molecular Mimicry [PDF]
PathogensThis review delves into the interactions between hepatitis C virus (HCV) and the host immune system, shedding light on how by using the mechanism of molecular mimicry, the virus strategically evades the immune system, resulting in a cascade of diverse ...
Lynette Goh, Nanda Kerkar
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Autoantibodies and Molecular Mimicry in Alphavirus Chronic Arthritis: A Systematic Review [PDF]
PathogensChronic arthritis following arthritogenic alphavirus infections presents symptoms resembling autoimmune rheumatic diseases, raising questions about the underlying mechanisms, including molecular mimicry and autoantibody production. This systematic review
Nosipho Zanele Masoto +1 more
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Potential clinical implications of molecular mimicry‐induced autoimmunity [PDF]
Immunity, Inflammation and DiseaseBackground Molecular mimicry is hypothesized to be a mechanism by which autoimmune diseases are triggered. It refers to sequence or structural homology between foreign antigens and self‐antigens, which can activate cross‐reactive lymphocytes that attack ...
Bandar A Suliman
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Molecular mimicry and cancer vaccine development [PDF]
Molecular Cancer, 2023 Background The development of cancer immunotherapeutic strategies relies on the identification and validation of optimal target tumor antigens, which should be tumor-specific as well as able to elicit a swift and potent anti-tumor immune response.
Maria Tagliamonte +6 more
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