Results 1 to 10 of about 3,245,847 (271)

Autoimmunity and molecular mimicry in tropical spastic paraparesis/human T-lymphotropic virus-associated myelopathy

Brazilian Journal of Medical and Biological Research, 2005
Viruses share antigenic sites with normal host cell components, a phenomenon known as molecular mimicry. It has long been suggested that viral infections might trigger an autoimmune response by several mechanisms including molecular mimicry.
F. García-Vallejo, M.C. Domínguez, O. Tamayo   +2 more
doaj   +1 more source

Lack of Evidence for Molecular Mimicry in HIV-Infected Subjects. [PDF]

PLoS ONE, 2015
Previous studies in HIV patients have reported autoantibodies to several human proteins, including erythropoietin (EPO), interferon-α (IFN-α), interleukin-2 (IL-2), and HLA-DR, as potential mediators of anemia or immunosuppression.
Peter D Burbelo, James S Klimavicz, Steve G Deeks, Joseph A Kovacs, Jack A Ragheb   +4 more
doaj   +1 more source

Molecular Mimicry Analyses Unveiled the Human Herpes Simplex and Poxvirus Epitopes as Possible Candidates to Incite Autoimmunity

Pathogens, 2022
Clinical epidemiological studies have reported that viral infections cause autoimmune pathology in humans. Host-pathogen protein sequences and structure-based molecular mimicry cause autoreactive T cells to cross-activate.
Sara Begum, Sara Aiman, Shujaat Ahmad, Abdus Samad, Mazen Almehmadi, Mamdouh Allahyani, Abdulelah Aljuaid, Sahib Gul Afridi, Asifullah Khan   +8 more
doaj   +1 more source

Müllerian mimicry as a result of codivergence between velvet ants and spider wasps.

PLoS ONE, 2014
Recent studies have delineated a large Nearctic Müllerian mimicry complex in Dasymutilla velvet ants. Psorthaspis spider wasps live in areas where this mimicry complex is found and are phenotypically similar to Dasymutilla.
Juanita Rodriguez, James P Pitts, Carol D von Dohlen, Joseph S Wilson   +3 more
doaj   +1 more source

Mining Autoimmune-Disorder-Linked Molecular-Mimicry Candidates in Clostridioides difficile and Prospects of Mimic-Based Vaccine Design: An In Silico Approach

Microorganisms, 2023
Molecular mimicry, a phenomenon in which microbial or environmental antigens resemble host antigens, has been proposed as a potential trigger for autoimmune responses.
Saleh Alshamrani, Mutaib M. Mashraqi, Ahmad Alzamami, Norah A. Alturki, Hassan H. Almasoudi, Mohammed Abdulrahman Alshahrani, Zarrin Basharat   +6 more
doaj   +1 more source

Epitopedia: identifying molecular mimicry between pathogens and known immune epitopes

ImmunoInformatics, 2023
Upon infection, foreign antigenic proteins stimulate the host's immune system to produce antibodies targeting the pathogen. These antibodies bind to regions on the antigen called epitopes.
Christian A Balbin, Janelle Nunez-Castilla, Vitalii Stebliankin, Prabin Baral, Masrur Sobhan, Trevor Cickovski, Ananda Mohan Mondal, Giri Narasimhan, Prem Chapagain, Kalai Mathee, Jessica Siltberg-Liberles   +10 more
doaj   +1 more source

Molecular Mimicry Mapping in Streptococcus pneumoniae: Cues for Autoimmune Disorders and Implications for Immune Defense Activation

Pathogens, 2023
Streptococcus pneumoniae contributes to a range of infections, including meningitis, pneumonia, otitis media, and sepsis. Infections by this bacterium have been associated with the phenomenon of molecular mimicry, which, in turn, may contribute to the ...
Mutaib M. Mashraqi, Ahmad Alzamami, Norah A. Alturki, Saleh Alshamrani, Mousa M. Alshahrani, Hassan H. Almasoudi, Zarrin Basharat   +6 more
doaj   +1 more source

The role of molecular mimicry in the etiology of Guillain Barré Syndrome [PDF]

Makedonsko Farmacevtski Bilten, 2011
Molecular mimicry between host tissue structures and microbial components has been proposed as the pathogenic mechanism for triggeringof autoimmune diseases by preceding infection.
Aleksandra Grozdanova, Slobodan Apostolski, Ljubica Suturkova   +2 more
doaj  

Molecular mimicry: Basis for autoimmunity [PDF]

Indian Journal of Clinical Biochemistry, 2000
Structural similarity between a viral protein and a self-component can trigger an autoimmune response, which is the basis of molecular mimicry. Alternatively an invading virus can induce an inflammatory response which in turn can initiate an attack by hitherto dormant T cells on a specific self-antigen, a phenomenon which is referred to as Bystander ...
openaire   +2 more sources

Interference in melanoma CD248 function reduces vascular mimicry and metastasis

Journal of Biomedical Science, 2022
Background Tumor vascular mimicry is an emerging issue that affects patient survival while having no treatment at the current moment. Despite several factors implicated in vascular mimicry, little is known about stromal factors that modulate tumor ...
Cheng-Hsiang Kuo, Ya-Fang Wu, Bi-Ing Chang, Chao-Kai Hsu, Chao-Han Lai, Hua-Lin Wu   +5 more
doaj   +1 more source