Results 11 to 20 of about 74,900 (283)
Molecular mimicry and autoimmunity
Journal of Autoimmunity, 2018 Molecular mimicry is one of the leading mechanisms by which infectious or chemical agents may induce autoimmunity. It occurs when similarities between foreign and self-peptides favor an activation of autoreactive T or B cells by a foreign-derived antigen in a susceptible individual.
Manuel Rojas +2 more
exaly +4 more sources
Molecular Mimicry between Meningococcal B Factor H-Binding Protein and Human Proteins [PDF]
Global Medical Genetics, 2023 This study calls attention on molecular mimicry and the consequent autoimmune cross reactivity as the molecular mechanism that can cause adverse events following meningococcal B vaccination and warns against active immunizations based on entire antigen.
Darja Kanduc
doaj +2 more sources
Autoimmune Diseases and Molecular Mimicry in Tuberculosis [PDF]
BiologyComorbidities in tuberculosis patients are increasing annually. Autoimmune pathology may influence the diagnosis and treatment of tuberculosis (TB). However, the molecular mimicry between Mycobacterium tuberculosis (Mtb) and human autoantigens is an ...
Leonid P. Churilov +5 more
doaj +2 more sources
Molecular mimicry between parasites and cancer: a novel approach for developing cancer vaccines and therapeutic antibodies [PDF]
Cancer Immunology, ImmunotherapyCancer is one of the most dreaded diseases worldwide. Conventional treatments such as surgery, chemotherapy, and radiotherapy have limitations and adverse effects. Cancer immunotherapy and targeted therapies offer new treatment options.
Maha Mohamed Eissa +5 more
doaj +2 more sources
Sarcoidosis, Cancer and Molecular Mimicry
International Journal of Immunopathology and Pharmacology, 2013 Molecular mimicry seems to be the most important factor for the heterogeneous clinical presentation and the immunopathogenesis of sarcoidosis. Molecular mimicry may occur as a result of altered activity of oncogenes. This can lead to crossed-type mediated body reactions targeting structurally similar sections or regions from the tissue homeostasis ...
Georgi Tchernev, Uwe Wollina
exaly +3 more sources
Molecular mimicry and autoimmunity in the time of COVID-19. [PDF]
J Autoimmun, 2023 Rojas M +6 more
europepmc +2 more sources
PLoS ONE, 2022 Microbial mimicry of the host proteins/peptides can elicit host auto-reactive T- or B-cells resulting in autoimmune disease(s). Since intrinsically disordered protein regions (IDPRs) are involved in several host cell signaling and PPI networks, molecular
Anjali Garg +3 more
doaj +2 more sources
Molecular Plant-Microbe Interactions, 2021 Molecular mimicry is one of the evolutionary strategies that parasites use to manipulate the host metabolism and perform an effective infection. This phenomenon has been observed in several animal and plant pathosystems.
Vinicio Armijos-Jaramillo +3 more
doaj +1 more source
Conformational Plasticity of HLA-B27 Molecules Correlates Inversely With Efficiency of Negative T Cell Selection [PDF]
, 2020 The development of autoimmune disorders is incompletely understood. Inefficient thymic T cell selection against self-peptides presented by major histocompatibility antigens (HLA in humans) may contribute to the emergence of auto-reactive effector cells ...
Loll, Bernhard +3 more
core +1 more source
Potential Autoimmunity Resulting from Molecular Mimicry between SARS-CoV-2 Spike and Human Proteins
Viruses, 2022 Molecular mimicry between viral antigens and host proteins can produce cross-reacting antibodies leading to autoimmunity. The coronavirus SARS-CoV-2 causes COVID-19, a disease curiously resulting in varied symptoms and outcomes, ranging from asymptomatic
Janelle Nunez-Castilla +10 more
doaj +1 more source