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Molecular mimicry as a mechanism of viral immune evasion and autoimmunity [PDF]
Nature CommunicationsMimicry of host protein structures, or ‘molecular mimicry’, is a common mechanism employed by viruses to evade the host’s immune system. Short linear amino acid (AA) molecular mimics can elicit cross-reactive antibodies and T cells from the host, but the
Cole Maguire +7 more
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Genome-wide identification of molecular mimicry candidates in parasites. [PDF]
PLoS ONE, 2011 Among the many strategies employed by parasites for immune evasion and host manipulation, one of the most fascinating is molecular mimicry. With genome sequences available for host and parasite, mimicry of linear amino acid epitopes can be investigated ...
Philipp Ludin +2 more
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Molecular Mimicry Between Epstein‐Barr Virus and Human Herpesvirus‐6 Proteins and Central Nervous System Proteins: Implications for T and B Cell Immunogenicity in an In Silico Study [PDF]
Immunity, Inflammation and DiseaseBackground The Epstein‐Barr virus (EBV) and human herpesvirus 6 (HHV‐6) are frequently linked to neuropsychiatric illnesses such as multiple sclerosis, depression, and chronic fatigue syndrome/myalgic encephalomyelitis.
Abbas F. Almulla +3 more
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Molecular mimicry and cancer vaccine development [PDF]
Molecular Cancer, 2023 Background The development of cancer immunotherapeutic strategies relies on the identification and validation of optimal target tumor antigens, which should be tumor-specific as well as able to elicit a swift and potent anti-tumor immune response.
Maria Tagliamonte +6 more
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Microbiome, Parkinson’s Disease and Molecular Mimicry
Cells, 2019 Parkinson’s Disease (PD) is typically classified as a neurodegenerative disease affecting the motor system. Recent evidence, however, has uncovered the presence of Lewy bodies in locations outside the CNS, in direct contact with the external ...
Fabiana Miraglia, Emanuela Colla
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Autoimmune Diseases and Molecular Mimicry in Tuberculosis [PDF]
BiologyComorbidities in tuberculosis patients are increasing annually. Autoimmune pathology may influence the diagnosis and treatment of tuberculosis (TB). However, the molecular mimicry between Mycobacterium tuberculosis (Mtb) and human autoantigens is an ...
Leonid P. Churilov +5 more
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, 2021 Bacterial molecular mimicry in autoimmune diseases is one of the leading mechanisms by which microorganisms may induce autoimmunity and survive in the host.
Marco Palma
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Molecular mimicry between parasites and cancer: a novel approach for developing cancer vaccines and therapeutic antibodies [PDF]
Cancer Immunology, ImmunotherapyCancer is one of the most dreaded diseases worldwide. Conventional treatments such as surgery, chemotherapy, and radiotherapy have limitations and adverse effects. Cancer immunotherapy and targeted therapies offer new treatment options.
Maha Mohamed Eissa +5 more
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PLoS ONE, 2022 Microbial mimicry of the host proteins/peptides can elicit host auto-reactive T- or B-cells resulting in autoimmune disease(s). Since intrinsically disordered protein regions (IDPRs) are involved in several host cell signaling and PPI networks, molecular
Anjali Garg +3 more
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Potential Autoimmunity Resulting from Molecular Mimicry between SARS-CoV-2 Spike and Human Proteins
Viruses, 2022 Molecular mimicry between viral antigens and host proteins can produce cross-reacting antibodies leading to autoimmunity. The coronavirus SARS-CoV-2 causes COVID-19, a disease curiously resulting in varied symptoms and outcomes, ranging from asymptomatic
Janelle Nunez-Castilla +10 more
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