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Molecular Portrait of Autoantigens in Type 1 Diabetes [PDF]
BiomoleculesThis review focuses on the molecular pathogenesis of Type 1 diabetes (T1D), specifically on the key autoantigens targeted by the autoimmune response and the clinical implications of their epitope specificity.
Ilya Kandinov +4 more
doaj +2 more sources
Frontiers in Endocrinology, 2022 Type 1 Diabetes (T1D) is an autoimmune disease that results from the destruction of pancreatic islet β-cells by auto-reactive T cells. The clinical management of T1D faces the lack of fully predictive biomarkers in its preclinical stage and of antigen ...
Pamela Houeiss +5 more
doaj +1 more source
Fcγ receptor activation mediates vascular inflammation and abdominal aortic aneurysm development
Clinical and Translational Medicine, 2021 Background Abdominal aortic aneurysm (AAA), a degenerative vascular pathology characterized by permanent dilation of the aorta, is considered a chronic inflammatory disease involving innate/adaptive immunity.
Laura Lopez‐Sanz +9 more
doaj +1 more source
Immunogenicity of autoantigens [PDF]
BMC Genomics, 2011 Autoantibodies against self-antigens have been associated not only with autoimmune diseases, but also with cancer and are even found in healthy individuals. The mechanism causing the autoantibody response remains elusive for the majority of the immunogenic antigens. To deepen the understanding of autoantibody responses, we ask whether natural-occurring,
Keller Andreas +7 more
openaire +3 more sources
Aminoacyl-tRNA Synthetases: On Anti-Synthetase Syndrome and Beyond
Frontiers in Immunology, 2022 Anti-synthetase syndrome (ASSD) is an autoimmune disease characterized by the presence of autoantibodies targeting one of several aminoacyl t-RNA synthetases (aaRSs) along with clinical features including interstitial lung disease, myositis, Raynaud’s ...
Angeles S. Galindo-Feria +6 more
doaj +1 more source
Frontiers in Immunology, 2022 COVID-19 is accompanied by a myriad of both transient and long-lasting autoimmune responses. Dermatan sulfate (DS), a glycosaminoglycan crucial for wound healing, has unique affinity for autoantigens (autoAgs) from apoptotic cells.
Julia Y. Wang +5 more
doaj +1 more source
B‐cell receptors of EBV‐negative Burkitt lymphoma bind modified isoforms of autoantigens
eJHaem, 2022 Burkitt lymphoma (BL) represents the most aggressive B‐cell‐lymphoma. Beside the hallmark of IG‐MYC‐translocation, surface B‐cell receptor (BCR) is expressed, and mutations in the BCR pathway are frequent.
Theresa Bock +24 more
doaj +1 more source
Frontiers in Immunology, 2020 The current paradigm of onset and progression of periodontitis includes oral dysbiosis directed by inflammophilic bacteria, leading to altered resolution of inflammation and lack of regulation of the inflammatory responses.
Lina J. Suárez +3 more
doaj +1 more source
Anti-Idiotypic mRNA Vaccine to Treat Autoimmune Disorders
Vaccines, 2023 The 80+ existing autoimmune disorders (ADs) affect billions with little prevention or treatment options, except for temporary symptomatic management, leading to enormous human suffering and a monumental financial burden. The autoantibodies formed in most
Sarfaraz K. Niazi
doaj +1 more source
Life, 2023 Wet age-related macular degeneration (wAMD) is a chronic inflammation-associated neurodegenerative disease affecting the posterior part of the eye in the aging population.
Sreeraj Kuruppilakath Manikandan +6 more
doaj +1 more source