Results 11 to 20 of about 27,579 (221)

The Role of Heat Shock Proteins in Type 1 Diabetes

Frontiers in Immunology, 2021
Type 1 diabetes (T1D) is a T-cell mediated autoimmune disease characterized by recognition of pancreatic β-cell proteins as self-antigens, called autoantigens (AAgs), followed by loss of pancreatic β-cells.
Abu Saleh Md Moin, Manjula Nandakumar, Abdoulaye Diane, Mohammed Dehbi, Alexandra E. Butler   +4 more
doaj   +1 more source

Neutrophils: An Important Player in Systemic Lupus Erythematosus [PDF]

Journal of Clinical and Diagnostic Research
The immune system contains several different cells that act as the first line of defence, reacting to a broad range of intruders as quickly as possible; an example of such cells is neutrophils. There has been increased focus on neutrophils due to the key
Nuha A Alkhattabi
doaj   +1 more source

A rare entity: Sympathetic ophthalmia presumably after blunt trauma to the phthisical eye and optical coherence tomography angiography metrics to monitor response to treatment

Clinical Case Reports, 2020
A blunt trauma to a phthisical eye may elicit sympathetic ophthalmia. Non invasive imaging such as use of optical coherence tomography and angiography metrics of the retinal and choroidal vasculature can help monitor response to the treatment.
Anadi Khatri, Satish Timalsena, Bal Kumar Khatri, Muna Kharel, Sudhir Gautam, Jeena Gurung, Santosh Kafle   +6 more
doaj   +1 more source

Pre‐existing humoral immune comebacks control the development of the severe form of coronavirus disease 2019 in Gaucher patients

Clinical and Translational Discovery, 2022
Coronavirus disease 2019 (COVID‐19) and the Gaucher disease (GD) exhibit lot of resemblances in induction of innate and adaptive immune inflammation that include the immune cells activation and the massive generation of pro‐inflammatory cytokines ...
Manoj Kumar Pandey
doaj   +1 more source

Molecular Insights Into the Relationship Between Autoimmune Thyroid Diseases and Breast Cancer: A Critical Perspective on Autoimmunity and ER Stress

Frontiers in Immunology, 2019
The etiopathologies behind autoimmune thyroid diseases (AITDs) unravel misbehavior of immune components leading to the corruption of immune homeostasis where thyroid autoantigens turn foe to the self.
Safikur Rahman, Ayyagari Archana, Arif Tasleem Jan, Durgashree Dutta, Abhishek Shankar, Jihoe Kim, Rinki Minakshi   +6 more
doaj   +1 more source

The relationship between chronic immune response and neurodegenerative damage in long COVID-19

Frontiers in Immunology, 2022
In the past two years, the world has faced the pandemic caused by the severe acute respiratory syndrome 2 coronavirus (SARS-CoV-2), which by August of 2022 has infected around 619 million people and caused the death of 6.55 million individuals globally ...
José Pedro Elizalde-Díaz, Clara Leticia Miranda-Narváez, Juan Carlos Martínez-Lazcano, Eduardo Martínez-Martínez   +3 more
doaj   +1 more source

Identification of autoantigens and their potential post-translational modification in EGPA and severe eosinophilic asthma

Frontiers in Immunology, 2023
BackgroundThe chronic airway inflammation in severe eosinophilic asthma (SEA) suggests potential autoimmune aetiology with unidentified autoantibodies analogous to myeloperoxidase (MPO) in ANCA-positive EGPA (eosinophilic granulomatosis with polyangiitis)
Ilaria Esposito, Ioanna Kontra, Chiara Giacomassi, Chiara Giacomassi, Sotiria Manou-Stathopoulou, James Brown, Richard Stratton, Richard Stratton, Galateia Verykokou, Roberto Buccafusca, Michael Stevens, Michael Stevens, Ahuva Nissim, Myles J. Lewis, Paul E. Pfeffer, Paul E. Pfeffer   +15 more
doaj   +1 more source

Neutrophil Extracellular Traps (NETs) Take the Central Stage in Driving Autoimmune Responses

Cells, 2020
Following fifteen years of research, neutrophil extracellular traps (NETs) are widely reported in a large range of inflammatory infectious and non-infectious diseases. Cumulating evidences from in vitro, in vivo and clinical diagnostics suggest that NETs
Esther Fousert, René Toes, Jyaysi Desai
doaj   +1 more source

Setting the Stage for Insulin Granule Dysfunction during Type-1-Diabetes: Is ER Stress the Culprit?

Biomedicines, 2022
Type-1-diabetes (T1D) is a multifactorial disorder with a global incidence of about 8.4 million individuals in 2021. It is primarily classified as an autoimmune disorder, where the pancreatic β-cells are unable to secrete sufficient insulin.
Aishwarya A. Makam, Anusmita Biswas, Lakshmi Kothegala, Nikhil R. Gandasi   +3 more
doaj   +1 more source

A comprehensive autoantigen-ome of autoimmune liver diseases identified from dermatan sulfate affinity enrichment of liver tissue proteins

BMC Immunology, 2019
Background Autoimmune diseases result from aberrant immune attacks by the body itself. It is mysterious how autoantigens, a large cohort of seemingly unconnected molecules expressed in different parts of the body, can induce similar autoimmune responses.
Wei Zhang, Jung-hyun Rho, Michael H. Roehrl, Julia Y. Wang   +3 more
doaj   +1 more source