Results 31 to 40 of about 33,778 (258)

Microarray ELISA for Autoantibody Screening in Connective Tissue Diseases [PDF]

Journal of Clinical and Diagnostic Research, 2012
Objective: This study was performed to demonstrate the use of an ELISA-based microarray technology which is termed as ‘PictArrays’, to identify autoantibody expression patterns in patients with symptoms of autoimmune connective tissue disease ...
Sarita Kumble, Lok Choi, Carlos Lopez-Muedano, Krishnanand D. Kumble   +3 more
doaj  

Identification of Autoantigens in Psoriatic Plaques Using Expression Cloning [PDF]

, 2004
To search for autoantigens in psoriatic plaques, we screened cDNA libraries of plaque epidermis with psoriatic serum samples. This approach has been highly successful in identifying tumor antigens, but has not been widely applied to autoimmune disease ...
Kupper, Thomas S., Sadat, Sara, Jones, David A., Rich, Benjamin, Yawalkar, Nikhil, Suh, Ki-Young   +5 more
core   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Selection strategy of serum autoantigens.

, 2015
The Venn diagram shows the autoantigen selection obtained according to (i) VIP scores >1.0 and (ii) a delta difference recognition frequency of 25%. 70 autoantigens overlap between the two filter criteria.
Saveria Mazzara (796365), Riccardo Lorenzo Rossi (796366), Mauro Bombaci (261852), Angela Cardaci (166908), Sergio Abrignani (173604), Antonia Sinisi (216486), Luigi Muratori (796367)   +6 more
core   +1 more source

A hierarchical role for classical pathway complement proteins in the clearance of apoptotic cells in vivo [PDF]

, 2000
The strongest susceptibility genes for the development of systemic lupus erythematosus (SLE) in humans are null mutants of classical pathway complement proteins. There is a hierarchy of disease susceptibility and severity according to the position of the
H. Terence Cook, Savill, John, Henson, Peter M, Cook, HT, Valerie A. Fadok, Taylor, P.R, Henson, PM, Mark J. Walport, Savill, JS, Walport, MJ, Philip R. Taylor, John S. Savill, Michael C. Carroll, Botto, M, Andrews, Mark, Taylor, PR, Fadok, Valerie A, Anna Carugati, Carroll, Michael C, Walport, Mark J, Carroll, MC, Marina Botto, Carugati, A, Peter M. Henson, Andrews, M, Mark Andrews, Botto, Marina, Fadok, VA, Carugati, Anna, Cook, H. Terence   +29 more
core   +1 more source

A repertoire of 124 potential autoantigens for autoimmune kidney diseases identified by dermatan sulfate affinity enrichment of kidney tissue proteins.

PLoS ONE, 2019
Autoantigens are the molecular targets in autoimmune diseases. They are a cohort of seemingly unrelated self-molecules present in different parts of the body, yet they can trigger a similar chain of autoimmune responses such as autoantibody production ...
Wei Zhang, Jung-Hyun Rho, Michael W Roehrl, Michael H Roehrl, Julia Y Wang   +4 more
doaj   +1 more source

Periodontitis and atherosclerotic cardiovascular disease: A critical appraisal

Periodontology 2000, EarlyView., 2023
Abstract In spite of intensive research efforts driving spectacular advances in terms of prevention and treatments, cardiovascular diseases (CVDs) remain a leading health burden, accounting for 32% of all deaths (World Health Organization. “Cardiovascular Diseases (CVDs).” WHO, February 1, 2017, https://www.who.int/news‐room/fact‐sheets/detail ...
Maria Clotilde Carra, Hélène Rangé, Giuseppina Caligiuri, Philippe Bouchard   +3 more
wiley   +1 more source

Oral Salmonella msbB Mutant as a Carrier for a Salmonella-Based Vaccine for Prevention and Reversal of Type 1 Diabetes

Frontiers in Immunology, 2021
A therapy that includes an oral vaccine for type 1 diabetes (T1D) using live attenuated Salmonella MvP728 (ΔhtrA/ΔpurD), cytokines (IL10 and TGFβ) and preproinsulin (PPI) antigen in combination with a sub-therapeutic dose of anti-CD3 mAb was developed by
Jacob Cobb, Jeffrey Rawson, Nelson Gonzalez, Michael Hensel, Fouad Kandeel, Mohamed I. Husseiny, Mohamed I. Husseiny   +6 more
doaj   +1 more source

An Epigenetics-Based Hypothesis of Autoantigen Development in Systemic Lupus Erythematosus

Epigenomes, 2020
Currently, we have a limited understanding of mechanisms leading to systemic lupus erythematosus, but we know that genetics, environmental factors, and epigenetics contribute to the disease. One common aspect of the various environmental triggers is that
Wesley Brooks
doaj   +1 more source

Ribonucleoprotein complexes as autoantigens [PDF]

Current Opinion in Immunology, 1995
Many intracellular proteins and nucleic acids, that are involved in important biosynthetic pathways, are targeted by autoantibodies occurring spontaneously in the sera of patients with systemic autoimmune diseases. Frequently, the autoantigens are assembled into multicomponent complexes containing both nucleic acid(s) and proteins.
Venrooij, W.J. van, Pruijn, G.J.M.
openaire   +3 more sources