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Frontiers in Endocrinology, 2023 ObjectiveEndoC-βH5 is a newly established human beta-cell model which may be superior to previous model systems. Exposure of beta cells to pro-inflammatory cytokines is widely used when studying immune-mediated beta-cell failure in type 1 diabetes.
Caroline Frørup +10 more
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Pro-Inflammatory Cytokines Promote the Transcription of Circular RNAs in Human Pancreatic β Cells
Non-Coding RNA, 2022 Circular RNAs (circRNAs) have recently been implicated in impaired β-cell function in diabetes. Using microarray-based profiling of circRNAs in human EndoC-βH1 cells treated with pro-inflammatory cytokines, this study aimed to investigate the expression ...
Simranjeet Kaur +9 more
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Advances in Human Immune System Mouse Models for Personalized Treg-Based Immunotherapies
Frontiers in Immunology, 2021 Immunodeficient mice engrafted with a functional human immune system [Human immune system (HIS) mice] have paved the way to major advances for personalized medicine and translation of immune-based therapies.
Isabelle Serr +8 more
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BMJ Open, 2023 Objectives Cardiovascular disease (CVD) is a precarious complication of type 1 diabetes (T1D). Alongside glycaemic control, lipid and blood pressure (BP) management are essential for the prevention of CVD.
Bruce H R Wolffenbuttel +4 more
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RESEARCH INVOLVING HUMAN SUBJECTS IN UKRAINE: HOW TO LEVERAGE ARISING OPPORTUNITIES?
Праці Наукового товариства імені Шевченка. Медичні науки, 2021 The review of the applications for grants of the National Research Foundation of Ukraine revealed evidence that many applicants-clinicians are not aware of the principles of Good Clinical Practice (GCP) that are implemented in different forms in the ...
Andriy Cherkas
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Molecular Metabolism, 2022 Background: The highly complex pathogenesis of Type 1 Diabetes is driven by several immune cell types with both effector and regulatory characteristics, which ultimately ends in the destruction of the insulin-producing beta cells.
Martin G. Scherm +5 more
doaj +1 more source
Frontiers in Immunology, 2021 Type 1 diabetes is an immune-driven disease, where the insulin-producing beta cells from the pancreatic islets of Langerhans becomes target of immune-mediated destruction.
Caroline Frørup +22 more
doaj +1 more source
The emerging role of lncRNAs in inflammatory bowel disease
Experimental and Molecular Medicine, 2018 Inflammatory bowel disease: The role of noncoding RNA Studying long noncoding RNAs (lncRNAs) may improve diagnosis and treatment of inflammatory bowel disease (IBD).
Reza Yarani +3 more
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miRNA-Mediated Immune Regulation in Islet Autoimmunity and Type 1 Diabetes
Frontiers in Endocrinology, 2020 The important role of microRNAs as major modulators of various physiological processes, including immune regulation and homeostasis, has been increasingly recognized.
Martin G. Scherm +4 more
doaj +1 more source
Residual C-peptide secretion and hypoglycemia awareness in people with type 1 diabetes
BMJ Open Diabetes Research & Care, 2021 Introduction This study aimed to assess the association between fasting serum C-peptide levels and the presence of impaired awareness of hypoglycemia (IAH) in people with type 1 diabetes.Research design and methods We performed a cross-sectional study ...
Giesje Nefs +9 more
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