Results 41 to 50 of about 1,499,825 (316)

Decline in titers of anti-idiotypic antibodies specific to autoantibodies to GAD65 (GAD65Ab) precedes development of GAD65Ab and type 1 diabetes. [PDF]

PLoS ONE, 2013
The humoral Idiotypic Network consisting of antibodies and their anti-idiotypic antibodies (anti-Id) can be temporarily upset by antigen exposure. In the healthy immune response the original equilibrium is eventually restored through counter-regulatory ...
Helena Elding Larsson, Ida Jönsson, Ake Lernmark, Sten Ivarsson, Jared R Radtke, Christiane S Hampe, Diabetes Prediction in Skåne (DiPiS), Type 1 Diabetes Trial Network   +7 more
doaj   +1 more source

The development, validation, and utility of the Diabetes Prevention Trial-Type 1 Risk Score (DPTRS) [PDF]

, 2015
This report details the development, validation, and utility of the Diabetes Prevention Trial-Type 1 (DPT-1) Risk Score (DPTRS) for type 1 diabetes (T1D).
Sosenko, Jay M, Diabetes Type 1 TrialNet and Diabetes Prevention Trial-Type 1 Study Groups, Skyler, Jay S, Palmer, Jerry P   +3 more
core   +1 more source

Fear of hypoglycaemia in parents of young children with type 1 diabetes : a systematic review [PDF]

, 2010
Background Many children with type 1 diabetes have poor glycaemic control. Since the Diabetes Control and Complications Trial (DCCT) showed that tighter control reduces complication rates, there has been more emphasis on intensified insulin therapy.
Sian Thomas, Norman Waugh, Noyes, Kathryn, Pamela Royle, Thomas Sian, Barnard Katharine, Waugh Norman, Barnard, Katharine D., Katharine Barnard, Waugh, Norman, Barnard, Katharine, Noyes Kathryn, Thomas, Sian, Royle Pamela, Kathryn Noyes, Royle, Pamela   +15 more
core   +1 more source

Inhibition of pyrimidine de novo synthesis fosters Treg cells and reduces diabetes development in models of Type 1 Diabetes

Molecular Metabolism
Objective: In autoimmune Type 1 Diabetes (T1D), aberrant immune activation promotes regulatory T cell (Treg) impairments thereby boosting progression of islet autoimmunity.
Hannah Hipp, Camilla Tondello, Hanna Gmehling, Lena K. Scholz, Antigoni Stavridou, Maike Becker, Anne-Marie Bührer, Edith Hintermann, Sandra M. Dirschl, Till M. Johannsmann, Martin G. Scherm, Hella Kohlhof, Isabelle Serr, Urs Christen, Carolin Daniel   +14 more
doaj   +1 more source

miRNA142-3p targets Tet2 and impairs Treg differentiation and stability in models of type 1 diabetes

Nature Communications, 2019
miRNA142-3p and Tet2 are separately known to regulate Treg. Here the authors show that miRNA142-3p targets Tet2 and by this opposes Treg differentiation in autoimmune diabetes.
Martin G. Scherm, Isabelle Serr, Adam M. Zahm, Jonathan Schug, Saverio Bellusci, Rossella Manfredini, Victoria K. Salb, Katharina Gerlach, Benno Weigmann, Anette-Gabriele Ziegler, Klaus H. Kaestner, Carolin Daniel   +11 more
doaj   +1 more source

The role of T cell miRNAs for regulatory T cell induction in islet autoimmunity

Molecular Metabolism, 2019
Background: microRNAs (miRNAs) have emerged as critical contributors to immune regulation and homeostasis, and their dysregulation is involved in the aberrant differentiation and function of T cell subsets.
Martin G. Scherm, Isabelle Serr, Klaus H. Kaestner, Carolin Daniel   +3 more
doaj   +1 more source

Primary understanding of type 1 diabetes as an autoimmune disease

Saudi Journal for Health Sciences, 2022
Type 1 diabetes (T1D) is classified as an autoimmune disease affecting a wide range of people worldwide. Beta cells in the pancreatic islets of Langerhans in the pancreases are responsible for insulin productions, which help in the exchange of blood ...
Mohamd A Alblihed
doaj   +1 more source

Transplantation in type 1 diabetes [PDF]

Nephrology Dialysis Transplantation, 2009
85% and 77%, respectively. The 1-, 3- and 5-year pancreas allograft survival rate after simultaneous pancreas– kidney transplantation was 86%, 79% and 71%, and patient survival was 95%, 91% and 86%, respectively (IPTR; http://www.iptr.umn.edu; [2]).
Christian, Morath, Martin, Zeier
openaire   +2 more sources

Hospital admission patterns subsequent to diagnosis of type 1 diabetes in children : a systematic review [PDF]

, 2007
Background Patients with type 1 diabetes are known to have a higher hospital admission rate than the underlying population and may also be admitted for procedures that would normally be carried out on a day surgery basis for non-diabetics.
Waugh Norman, Waugh, Norman, Angus, Val C., Norman Waugh, Angus, Val C, Val C Angus, Angus Val C   +6 more
core   +1 more source

Collagenase Isoforms for Pancreas Digestion

Cell Transplantation, 2009
The available information concerning the characteristics and composition of collagenase batches, which are effective in the digestion of human pancreas for islet transplants, is scarce and incomplete.
Federico Bertuzzi, Silvia Cainarca, Simona Marzorati, Angela Bachi, Barbara Antonioli, Rita Nano, Roberto Verzaro, Camillo Ricordi   +7 more
doaj   +1 more source