Results 31 to 40 of about 36,666,975 (299)

Recent advances in understanding Type 1 Diabetes [version 1; referees: 2 approved]

F1000Research, 2016
Type 1 diabetes is a multifactorial disease in which genetic and environmental factors play a key role. The triggering event is still obscure, and so are many of the immune events that follow.
Gustaf Christoffersson, Teresa Rodriguez-Calvo, Matthias von Herrath   +2 more
doaj   +1 more source

Diabetic nephropathy in type 1 diabetes

Minerva Medica, 2018
Diabetic nephropathy (DN) also named diabetic kidney disease (DN) is one of the leading causes of mortality in people with diabetes. The aim of this review is to update the medical literature, the theories behind its early natural history, the pathways of its pathogenesis, its diagnosis and treatment.
Papadopoulou-Marketou, N., Paschou, S.A., Marketos, N., Adamidi, S., Adamidis, S., Kanaka-Gantenbein, C.   +5 more
openaire   +3 more sources

Neutrophils in type 1 diabetes [PDF]

Journal of Diabetes Investigation, 2016
AbstractType 1 diabetes is an autoimmune disease that afflicts millions of people worldwide. It occurs as the consequence of destruction of insulin‐producing pancreatic β‐cells triggered by genetic and environmental factors. The initiation and progression of the disease involves a complicated interaction between β‐cells and immune cells of both innate ...
Huang, Juan, Xiao, Yang, Xu, Aimin, Zhou, Zhiguang   +3 more
openaire   +2 more sources

Acute hypoglycemia impairs executive cognitive function in adults with and without type 1 diabetes [PDF]

, 2013
OBJECTIVE Acute hypoglycemia impairs cognitive function in several domains. Executive cognitive function governs organization of thoughts, prioritization of tasks, and time management.
Graveling, Alex J., Deary, Ian J., Frier, Brian M.   +2 more
core   +1 more source

β Cell and Autophagy: What Do We Know?

Biomolecules, 2023
Pancreatic β cells are central to glycemic regulation through insulin production. Studies show autophagy as an essential process in β cell function and fate.
Hamid-Reza Mohammadi-Motlagh, Mona Sadeghalvad, Niloofar Yavari, Rosita Primavera, Setareh Soltani, Shashank Chetty, Abantika Ganguly, Shobha Regmi, Tina Fløyel, Simranjeet Kaur, Aashiq H. Mirza, Avnesh S. Thakor, Flemming Pociot, Reza Yarani   +13 more
doaj   +1 more source

Diabetes distress and marriage in Type-1 diabetes

Indian Journal of Community Medicine, 2018
In spite of the large number of people with Type-1 diabetes mellitus (T1DM) in India, India is not a diabetes-friendly society. The society suffers from lots of myths regarding diabetes and insulin use. This review highlights challenges faced by young people living with T1DM with regards to marriage, associated diabetes distress, and suggests potential
Deepak Khandelwal, Lovely Gupta, Sanjay Kalra, Amit Vishwakarma, Priti Rishi Lal, Deep Dutta   +5 more
openaire   +3 more sources

Type 1 diabetes vaccine candidates promote human Foxp3+Treg induction in humanized mice

Nature Communications, 2016
Type 1 diabetes is associated with the loss of self-tolerance to the insulin-producing β-cells in the pancreas. Here the authors show that vaccination with insulin mimetopes can induce human insulin-specific regulatory T cells to mediate tolerance in a ...
Isabelle Serr, Rainer W. Fürst, Peter Achenbach, Martin G. Scherm, Füsun Gökmen, Florian Haupt, Eva-Maria Sedlmeier, Annette Knopff, Leonard Shultz, Richard A. Willis, Anette-Gabriele Ziegler, Carolin Daniel   +11 more
doaj   +1 more source

A quantitative measure of treatment response in recent‐onset type 1 diabetes

Endocrinology, Diabetes & Metabolism, 2020
Introduction This paper develops a methodology and defines a measure that can be used to separate subjects that received an experimental therapy into those that benefitted from those that did not in recent‐onset type 1 diabetes.
Brian N. Bundy, Jeffrey P. Krischer, for the Type 1 Diabetes TrialNet Study Group   +2 more
doaj   +1 more source

Means, Motive, and Opportunity: Do Non-Islet-Reactive Infiltrating T Cells Contribute to Autoimmunity in Type 1 Diabetes?

Frontiers in Immunology, 2021
In human type 1 diabetes and animal models of the disease, a diverse assortment of immune cells infiltrates the pancreatic islets. CD8+ T cells are well represented within infiltrates and HLA multimer staining of pancreas sections provides clear evidence
Teresa Rodriguez-Calvo, Teresa Rodriguez-Calvo, Gustaf Christoffersson, Gustaf Christoffersson, Christine Bender, Matthias G. von Herrath, Roberto Mallone, Roberto Mallone, Sally C. Kent, Eddie A. James   +9 more
doaj   +1 more source

Adiposity-Related Heterogeneity in Patterns of Type 2 Diabetes Susceptibility Observed in Genome-Wide Association Data [PDF]

, 2009
OBJECTIVE-This study examined how differences in the BMI distribution of type 2 diabetic case subjects affected genome-wide patterns of type 2 diabetes, association mid considered the implications for the etiological heterogeneity of type 2 diabetes ...
Timpson, NJ, David P. Strachan, Weedon, Michael N., Weedon, MN, Nicholas J. Timpson, Rayner, NW, Morris, Andrew D., Zeggini, Eleftheria, Mark Walker, Alex S.F. Doney, Doney, ASF, Palmer, Colin N A, Timothy M. Frayling, Strachan, David P., Hitman, Graham A., Lindgren, Cecilia M., Hattersley, Andrew T., Hitman, GA, Lindgren, CM, Randall, Joshua, Doney, Alex S. F.; id_orcid, Graham A. Hitman, Andrew T. Hattersley, Walker, Mark, Palmer, CN, Hattersley, AT, Rayner, N. William, McCarthy, MI, Timpson, Nicholas J., Michael N. Weedon, Willem H. Ouwehand, Palmer, CNA, Walker, M, Andrew D. Morris, Doney, Alex S F, N. William Rayner, Lindgren, Cecilia, Randall, J, Mark I. McCarthy, Frayling, Timothy M., Strachan, DP, Morris, AD, Cecilia M. Lindgren, Doney, AS, Joshua Randall, McCarthy, Mark I., Zeggini, E, Eleftheria Zeggini, Ouwehand, WH, Pamler, CAN, Ouwehand, Willem H., Colin N.A. Palmer, Frayling, TM, Palmer, Colin N. A.; id_orcid   +53 more
core   +1 more source