Results 31 to 40 of about 1,499,825 (316)

Immunology of type 1 diabetes [PDF]

QJM: An International Journal of Medicine, 2005
The incidence of type 1 diabetes in the UK is 20 per 100 000 and increasing, particularly in the under-5-years age group.1 It comes with the burden of daily insulin injection and blood testing, as well as both short- and long-term complications, and this can include premature death.
P, Narendran, E, Estella, S, Fourlanos
openaire   +2 more sources

Recent advances in understanding Type 1 Diabetes [version 1; referees: 2 approved]

F1000Research, 2016
Type 1 diabetes is a multifactorial disease in which genetic and environmental factors play a key role. The triggering event is still obscure, and so are many of the immune events that follow.
Gustaf Christoffersson, Teresa Rodriguez-Calvo, Matthias von Herrath   +2 more
doaj   +1 more source

β Cell and Autophagy: What Do We Know?

Biomolecules, 2023
Pancreatic β cells are central to glycemic regulation through insulin production. Studies show autophagy as an essential process in β cell function and fate.
Hamid-Reza Mohammadi-Motlagh, Mona Sadeghalvad, Niloofar Yavari, Rosita Primavera, Setareh Soltani, Shashank Chetty, Abantika Ganguly, Shobha Regmi, Tina Fløyel, Simranjeet Kaur, Aashiq H. Mirza, Avnesh S. Thakor, Flemming Pociot, Reza Yarani   +13 more
doaj   +1 more source

Diabetes distress and marriage in Type-1 diabetes

Indian Journal of Community Medicine, 2018
In spite of the large number of people with Type-1 diabetes mellitus (T1DM) in India, India is not a diabetes-friendly society. The society suffers from lots of myths regarding diabetes and insulin use. This review highlights challenges faced by young people living with T1DM with regards to marriage, associated diabetes distress, and suggests potential
Deepak Khandelwal, Lovely Gupta, Sanjay Kalra, Amit Vishwakarma, Priti Rishi Lal, Deep Dutta   +5 more
openaire   +3 more sources

Skin microvascular vasodilatory capacity in offspring of two parents with Type 2 diabetes [PDF]

, 2001
Aims<br/> Microvascular dysfunction occurs in Type 2 diabetes and in subjects with fasting hyperglycaemia. It is unclear whether this dysfunction relates to dysglycaemia.
Shore, A.C., Lowe, G.D., Lee, B.C., B. C. Lee, Clark, P.M., A. Rumley, J. E. Tooke, A. T. Hattersley, Rumley, A., Tooke, J.E., G. D. Lowe, A. C. Shore, J. M. Humphreys, Humphreys, J.M., P. M. Clark, Hattersley, A.T.   +15 more
core   +1 more source

Type 1 diabetes vaccine candidates promote human Foxp3+Treg induction in humanized mice

Nature Communications, 2016
Type 1 diabetes is associated with the loss of self-tolerance to the insulin-producing β-cells in the pancreas. Here the authors show that vaccination with insulin mimetopes can induce human insulin-specific regulatory T cells to mediate tolerance in a ...
Isabelle Serr, Rainer W. Fürst, Peter Achenbach, Martin G. Scherm, Füsun Gökmen, Florian Haupt, Eva-Maria Sedlmeier, Annette Knopff, Leonard Shultz, Richard A. Willis, Anette-Gabriele Ziegler, Carolin Daniel   +11 more
doaj   +1 more source

Means, Motive, and Opportunity: Do Non-Islet-Reactive Infiltrating T Cells Contribute to Autoimmunity in Type 1 Diabetes?

Frontiers in Immunology, 2021
In human type 1 diabetes and animal models of the disease, a diverse assortment of immune cells infiltrates the pancreatic islets. CD8+ T cells are well represented within infiltrates and HLA multimer staining of pancreas sections provides clear evidence
Teresa Rodriguez-Calvo, Teresa Rodriguez-Calvo, Gustaf Christoffersson, Gustaf Christoffersson, Christine Bender, Matthias G. von Herrath, Roberto Mallone, Roberto Mallone, Sally C. Kent, Eddie A. James   +9 more
doaj   +1 more source

Increased glycation and oxidative damage to apolipoprotein B100 of LDL cholesterol in patients with type 2 diabetes and effect of metformin [PDF]

, 2010
OBJECTIVE The aim of this study was to investigate whether apolipoprotein B100 of LDL suffers increased damage by glycation, oxidation, and nitration in patients with type 2 diabetes, including patients receiving metformin therapy.
Rabbani, Naila, D. Zehnder, A. Ceriello, P. J. Thornalley, N. Rabbani, Zehnder, Daniel, Chittari, Madhu Varma, C. W. Bodmer, Bodmer, Charles W., Ceriello, Antonio, M. V. Chittari, Thornalley, Paul J.   +11 more
core   +1 more source

A quantitative measure of treatment response in recent‐onset type 1 diabetes

Endocrinology, Diabetes & Metabolism, 2020
Introduction This paper develops a methodology and defines a measure that can be used to separate subjects that received an experimental therapy into those that benefitted from those that did not in recent‐onset type 1 diabetes.
Brian N. Bundy, Jeffrey P. Krischer, for the Type 1 Diabetes TrialNet Study Group   +2 more
doaj   +1 more source

Relationship between plasma sialic acid and fibinogen concentration and incident micro-and macrovascular complications in type 1 diabetes [PDF]

, 2008
AIMS/HYPOTHESIS: Type 1 diabetes is associated with an increased risk of vascular complications. This increased risk could be explained by sialic acid and/or fibrinogen.
MICCOLI, ROBERTO, Pickup, J C, SOEDAMAH MUTHU SS, S. S. Soedamah-Muthu, J. H. Fuller, Chaturvedi, N, On behalf of EURODIAB PCS STUDY GROUP, CHATURVEDI N, Pickup, J.C., Fuller, J.H., Fuller, J H, FULLER JH, N. Chaturvedi, null null, PICKUP JC, J. C. Pickup, Soedamah-Muthu, S.S., Soedamah-Muthu, S S, Chaturvedi, N.   +18 more
core   +1 more source