Results 11 to 20 of about 1,499,825 (316)
Inflammasomes and Type 1 Diabetes [PDF]
Frontiers in Immunology, 2021 Microbiota have been identified as an important modulator of susceptibility in the development of Type 1 diabetes in both animal models and humans. Collectively these studies highlight the association of the microbiota composition with genetic risk ...James Alexander Pearson, F. Susan Wong, Li Wen +2 moredoaj +3 more sourcesType 1 diabetes [PDF]
The Lancet, 2018 Type 1 diabetes is a chronic autoimmune disease characterised by insulin deficiency and resultant hyperglycaemia. Knowledge of type 1 diabetes has rapidly increased over the past 25 years, resulting in a broad understanding about many aspects of the disease, including its genetics, epidemiology, immune and β-cell phenotypes, and disease burden ...DiMeglio, Linda A., Evans-Molina, Carmella, Oram, Richard A. +2 moreopenaire +4 more sourcesType 1 diabetes
The Lancet, 2023 Type 1 diabetes is a chronic disease caused by autoimmune destruction of pancreatic β cells. Individuals with type 1 diabetes are reliant on insulin for survival. Despite enhanced knowledge related to the pathophysiology of the disease, including interactions between genetic, immune, and environmental contributions, and major strides in treatment and ...Quattrin, Teresa, Mastrandrea, Lucy D, Walker, Lucy SK +2 moreopenaire +3 more sources350-OR: The Oral Disposition Index (ODI) Predicts Type 1 Diabetes (T1D) in Autoantibody-Positive (Ab+) Individuals [PDF]
, 2022 The ODI is a measure of β-cell function accounting for insulin sensitivity. ODI has primarily been studied in adults and shown to be inversely predictive of type 2 diabetes (T2D) ; however, little is known about ODI's prediction of T1D. We thus used data Sosenko, Jay, DIABETES PREVENTION TRIAL TYPE 1, TYPE 1 DIABETES TRIALNET, Jacobsen, Laura, Atkinson, Mark, Ismail, Heba, Cuthbertson, David, Redondo, Maria +6 morecore +1 more sourceType 1 diabetes [PDF]
The Lancet, 2014 Over the past decade, knowledge of the pathogenesis and natural history of type 1 diabetes has grown substantially, particularly with regard to disease prediction and heterogeneity, pancreatic pathology, and epidemiology. Technological improvements in insulin pumps and continuous glucose monitors help patients with type 1 diabetes manage the challenge ...Mark A, Atkinson, George S, Eisenbarth, Aaron W, Michels +2 moreopenaire +2 more sourcesType 1 Diabetes [PDF]
Clinical Chemistry, 1999 AbstractType 1 (insulin-dependent) diabetes occurs worldwide and can appear at any age. The genetic susceptibility is strongly associated with HLA-DQ and DR on chromosome 6, but genetic factors on other chromosomes such as the insulin gene on chromosome 11 and the cytotoxic T-lymphocyte antigen gene on chromosome 2 may modulate disease risk.openaire +2 more sourcesBreast-Feeding and Childhood-Onset Type 1 Diabetes : A pooled analysis of individual participant data from 43 observational studies [PDF]
, 2012 OBJECTIVE To investigate if there is a reduced risk of type 1 diabetes in children breastfed or exclusively breastfed by performing a pooled analysis with adjustment for recognized confounders. RESEARCH DESIGN AND METHODS Relevant studies were identified Cinek, O., Joner, Geir, Brigis, G, Parslow, Roger C, Joner, Geir,, Geir Joner (8519850), Schober, E, Stene, Lars C, Radon, K, Carine E de Beaufort (16166561), Devoti, Gabriele, Karavanaki, K, Rosenbauer, Joachim,, Cardwell, Chris R, Ponsonby, Anne-Louise, Stene, Lars C., Stene, Lars C,, Memon, Anjum, Joner, G, Savilahti, E., Ionescu-Tirgoviste, C., C Patterson, Chris,, Urbonaite, B., Devoti, G., Patterson, Chris C., Constantin Ionescu-Tirgoviste (542793), Memon, A., Wadsworth, EJ, Urbonaite, Brone,, Patterson, Christopher, Strotmeyer, ES, Urbonaite, Brone, Chetwynd, Amanda,, Cardwell, Christopher; id_orcid, Lee-Ming Chuang (215892), Svensson, Jannet, Pozzilli, Paolo, Perez-Bravo, Francisco,, Wadsworth, Emma J.K., Chuang, Lee-Ming,, Brone Urbonaite (16166552), Benson, Victoria,, Gimeno, S.G., de Beaufort, Carine E, Pozzilli, P., DE BEAUFORT, Carine, Stene, LC, C Patterson, Chris, Radon, Katja, Karavanaki, Kyriaki,, Svensson, J., Goldacre, MJ, Michael J Goldacre (8832635), Katja Radon (487886), Goldacre, Michael J,, 莊立民, Goldacre, Michael J., Benson, V, Gimeno, Suely Godoy Agostinho [UNIFESP], Ludvigsson, Johnny, Joner, G., Paolo Pozzilli (310706), Savilahti, Erkki, Sipetic, Sandra,, Schober, E., Sipetic, Sandra, Rabiei, S, Brigis, Girts,, Anjum Memon (4461844), de Beaufort, Carine E,, Svensson, J, Cinek, Ondrej, Mona Salem (16166564), Chuang, Lee-Ming, Benson, V., Sandra Sipetic (16166558), Salem, Mona, Elsa S Strotmeyer (16166546), Perez-Bravo, Francisco, Patterson, CC, Strotmeyer, E.S., Karavanaki, K., Salem, Mona,, Brigis, G., Wadsworth, Emma J K,, Cardwell, CR, Perez-Bravo, F, Victoria Benson (6821780), Karavanaki, Kyriaki, Girts Brigis (4725450), Chetwynd, Amanda, Schober, Edith,, Roger C Parslow (9861266), Goldacre, M.J., Kyriaki Karavanaki (336472), Rabiei, Samira,, Ionescu-Tirgoviste, Constantin,, Rabiei, Samira, De Beaufort, Carine E., Sipetic, S, Cinek, O, Chuang, LM, Patterson, Chris C, Rosenbauer, Joachim, Schober, Edith, Chetwynd, A., Memon, A, Gimeno, SG, Ondrej Cinek (196591), Harrild, K., Ponsonby, Anne-Louise,, Svensson, Jannet,, Anne-Louise Ponsonby (340858), Chuang, Lee Ming, Beaufort, Carine E. de, Chris R Cardwell (5356490), Jannet Svensson (418468), Chetwynd, A, Ionescu-Tirgoviste, Constantin, Savilahti, Erkki,, Lars C Stene (16166537), Suely G Gimeno (16166540), Memon, Anjum,, Ponsonby, AL, Strotmeyer, Elsa S, Brigis, Girts, Rosenbauer, J., Chris C Patterson (5364881), Radon, Katja,, Parslow, RC, Wadsworth, EJK, Emma J K Wadsworth (16166543), Harrild, K, Parslow, R.C., Cardwell, Chris R., De Beaufort, CE, Ionescu-Tirgoviste, C, Cardwell, Chris R,, Devoti, G, Cardwell, C.R., Salem, M., Samira Rabiei (16166567), Cardwell, Chris R.;Stene, Lars C.;Ludvigsson, Johnny;Rosenbauer, Joachim;Cinek, Ondrej;Svensson, Jannet;Perez-Bravo, Francisco;Memon, Anjum;Gimeno, Suely G.;Wadsworth, Emma J. K.;Strotmeyer, Elsa S.;Goldacre, Michael J.;Radon, Katja;Chuang, Lee-Ming;Parslow, Roger C.;Chetwynd, Amanda;Karavanaki, Kyriaki;Brigis, Girts;Pozzilli, Paolo;Urbonaite, Brone;Schober, Edith;Devoti, Gabriele;Sipetic, Sandra;Joner, Geir;Ionescu-Tirgoviste, Constantin;de Beaufort, Carine E.;Harrild, Kirsten;Benson, Victoria;Savilahti, Erkki;Ponsonby, Anne-Louise;Salem, Mona;Rabiei, Samira;Patterson, Chris C., Edith Schober (640994), Wadsworth, Emma J. K., Cinek, Ondrej,, Ponsonby, A.L., Ponsonby, Anne Louise, Ludvigsson, J, Savilahti, E, Francisco Perez-Bravo (206402), Parslow, Roger C., Johnny Ludvigsson (167260), Benson, Victoria, Amanda Chetwynd (16166549), Wadsworth, Emma J K, Parslow, Roger C,, Ludvigsson, J., Sipetic, S., Rabiei, S., Stene, L.C., Rosenbauer, J, Pozzilli, P, Chuang, L.M., Erkki Savilahti (68955), Strotmeyer, Elsa S., Urbonaite, B, Wadsworth, E.J., Strotmeyer, Elsa S,, Devoti, Gabriele,, Ludvigsson, Johnny,, Goldacre, Michael, Joachim Rosenbauer (445335), Gimeno, Suely G, Perez-Bravo, F., Radon, K., Patterson, C.C., Pozzilli, Paolo,, Harrild, Kirsten, Gimeno, Suely G,, Salem, M, Goldacre, Michael J, Gimeno, Suely G., Harrild, Kirsten,, Kirsten Harrild (563534), Gabriele Devoti (16166555) +185 morecore +1 more sourceThe TCF7L2locus and type 1 diabetes [PDF]
BMC Medical Genetics, 2007 TCF7L2 belongs to a subfamily of TCF7-like HMG box-containing transcription factors, and maps to human chromosome 10q25.3. A recent study identified genetic association of type 2 diabetes (T2D) with this gene, correlated with diminished insulin secretion.Polychronakos Constantin, Qu Hui-Qiopenaire +3 more sourcesProgression to microalbuminuria in type 1 diabetes: development and validation of a prediction rule [PDF]
, 2009 AIMS/HYPOTHESIS: Microalbuminuria is common in type 1 diabetes and is associated with an increased risk of renal and cardiovascular disease. We aimed to develop and validate a clinical prediction rule that estimates the absolute risk of microalbuminuria. K. G. M. Moons, P.-H. Groop, S. S. Soedamah-Muthu, M. Rewers, Y. Vergouwe, J. H. Fuller, C. Forsblom, Orchard, T.J., Rewers, M., Forsblom, C., Snell-Bergeon, J.K., T. J. Orchard, Fuller, J.H., D. M. Maahs, J. K. Snell-Bergeon, J. Zgibor, Vergouwe, Y., Moons, K.G.M., N. Chaturvedi, Groop, P.H., Soedamah-Muthu, S.S., Zgibor, J., Maahs, D.M., Chaturvedi, N. +23 morecore +1 more sourceRoles of Bcl-3 in the pathogenesis of murine type 1 diabetes [PDF]
, 2010 OBJECTIVE: It has long been recognized that autoimmunity is often associated with immunodeficiency. The mechanism underlying this paradox is not well understood.Ruaidhri J. Carmody, Shi-Jun Zheng, Scott Palmer, Palmer, S., Ruan, Q., Chen, Y.H., Carmody, R.J., Youhai H. Chen, Zheng, S.-J., Qingguo Ruan +9 morecore +1 more source
