Results 11 to 20 of about 1,336,975 (266)
Inflammasomes and Type 1 Diabetes [PDF]
Frontiers in Immunology, 2021 Microbiota have been identified as an important modulator of susceptibility in the development of Type 1 diabetes in both animal models and humans. Collectively these studies highlight the association of the microbiota composition with genetic risk ...
James Alexander Pearson +2 more
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The Lancet, 2018 Type 1 diabetes is a chronic autoimmune disease characterised by insulin deficiency and resultant hyperglycaemia. Knowledge of type 1 diabetes has rapidly increased over the past 25 years, resulting in a broad understanding about many aspects of the disease, including its genetics, epidemiology, immune and β-cell phenotypes, and disease burden ...
DiMeglio, Linda A. +2 more
openaire +4 more sources
Frontiers in Endocrinology, 2023 ObjectiveEndoC-βH5 is a newly established human beta-cell model which may be superior to previous model systems. Exposure of beta cells to pro-inflammatory cytokines is widely used when studying immune-mediated beta-cell failure in type 1 diabetes.
Caroline Frørup +10 more
doaj +1 more source
Pro-Inflammatory Cytokines Promote the Transcription of Circular RNAs in Human Pancreatic β Cells
Non-Coding RNA, 2022 Circular RNAs (circRNAs) have recently been implicated in impaired β-cell function in diabetes. Using microarray-based profiling of circRNAs in human EndoC-βH1 cells treated with pro-inflammatory cytokines, this study aimed to investigate the expression ...
Simranjeet Kaur +9 more
doaj +1 more source
The Lancet, 2023 Type 1 diabetes is a chronic disease caused by autoimmune destruction of pancreatic β cells. Individuals with type 1 diabetes are reliant on insulin for survival. Despite enhanced knowledge related to the pathophysiology of the disease, including interactions between genetic, immune, and environmental contributions, and major strides in treatment and ...
Quattrin, Teresa +2 more
openaire +3 more sources
The Lancet, 2014 Over the past decade, knowledge of the pathogenesis and natural history of type 1 diabetes has grown substantially, particularly with regard to disease prediction and heterogeneity, pancreatic pathology, and epidemiology. Technological improvements in insulin pumps and continuous glucose monitors help patients with type 1 diabetes manage the challenge ...
Mark A, Atkinson +2 more
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Advances in Human Immune System Mouse Models for Personalized Treg-Based Immunotherapies
Frontiers in Immunology, 2021 Immunodeficient mice engrafted with a functional human immune system [Human immune system (HIS) mice] have paved the way to major advances for personalized medicine and translation of immune-based therapies.
Isabelle Serr +8 more
doaj +1 more source
BMJ Open, 2023 Objectives Cardiovascular disease (CVD) is a precarious complication of type 1 diabetes (T1D). Alongside glycaemic control, lipid and blood pressure (BP) management are essential for the prevention of CVD.
Bruce H R Wolffenbuttel +4 more
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Molecular Metabolism, 2022 Background: The highly complex pathogenesis of Type 1 Diabetes is driven by several immune cell types with both effector and regulatory characteristics, which ultimately ends in the destruction of the insulin-producing beta cells.
Martin G. Scherm +5 more
doaj +1 more source
Clinical Chemistry, 1999 AbstractType 1 (insulin-dependent) diabetes occurs worldwide and can appear at any age. The genetic susceptibility is strongly associated with HLA-DQ and DR on chromosome 6, but genetic factors on other chromosomes such as the insulin gene on chromosome 11 and the cytotoxic T-lymphocyte antigen gene on chromosome 2 may modulate disease risk.
openaire +2 more sources