The TCF7L2locus and type 1 diabetes [PDF]
BMC Medical Genetics, 2007 TCF7L2 belongs to a subfamily of TCF7-like HMG box-containing transcription factors, and maps to human chromosome 10q25.3. A recent study identified genetic association of type 2 diabetes (T2D) with this gene, correlated with diminished insulin secretion.
Polychronakos Constantin, Qu Hui-Qi
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PDE12 in type 1 diabetes [PDF]
Scientific Reports, 2022 AbstractType 1 diabetes (T1D) incidence is increased after COVID-19 infection in children under 18 years of age. Interferon-α-activated oligoadenylate synthetase and downstream RNAseL activation degrade pathogen RNA, but can also damage host RNA when RNAseL activity is poorly regulated.
Tekin, Hasim +6 more
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Progression to microalbuminuria in type 1 diabetes: development and validation of a prediction rule [PDF]
, 2009 AIMS/HYPOTHESIS: Microalbuminuria is common in type 1 diabetes and is associated with an increased risk of renal and cardiovascular disease. We aimed to develop and validate a clinical prediction rule that estimates the absolute risk of microalbuminuria.
K. G. M. Moons +23 more
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Identification of Type 1 Diabetes-Associated DNA Methylation Variable Positions That Precede Disease Diagnosis [PDF]
, 2011 Monozygotic (MZ) twin pair discordance for childhood-onset Type 1 Diabetes (T1D) is similar to 50%, implicating roles for genetic and non-genetic factors in the aetiology of this complex autoimmune disease.
Busato, F +72 more
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Young people with type 1 diabetes and their transition to adult services. [PDF]
, 2013 More than 85% of children and young people with type 1 diabetes are not achieving the recommended target of
Kime, N
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Residual C-peptide secretion and hypoglycemia awareness in people with type 1 diabetes
BMJ Open Diabetes Research & Care, 2021 Introduction This study aimed to assess the association between fasting serum C-peptide levels and the presence of impaired awareness of hypoglycemia (IAH) in people with type 1 diabetes.Research design and methods We performed a cross-sectional study ...
Giesje Nefs +9 more
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Antigen-Specific Treg Therapy in Type 1 Diabetes – Challenges and Opportunities
Frontiers in Immunology, 2021 Regulatory T cells (Tregs) are key mediators of peripheral self-tolerance and alterations in their frequencies, stability, and function have been linked to autoimmunity.
Isabelle Serr +7 more
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A journey toward an open data culture through transformation of shared data into a data resource
Data & Policy, 2022 The transition to open data practices is straightforward albeit surprisingly challenging to implement largely due to cultural and policy issues. A general data sharing framework is presented along with two case studies that highlight these challenges and
Scott D. Kahn, Anne Koralova
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BMJ, 2011 Type 1 diabetes in childhood is one of the commoner long term conditions of childhood. It is treated by specialist teams in secondary care using increasingly intensive insulin regimens, but the onset is generally diagnosed by primary care physicians, sometimes later than is ideal.
Ali, K, Harnden, A, Edge, J
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A gyermekkori 1-es típusú diabétesz genetikai és humorális immunológiai hátterének vizsgálata = Genetic and humoral immunologic determinants of childhood-onset type 1 diabetes [PDF]
, 2007 Az OTKA pályázat munkatervében kitűzött célok megvalósultak. A program az elmúlt három év alatt országos diabetes genetikai projektté nőtte ki magát (HUN-T1D-GENES program; www.diabet.hu/ diabetesgenetics).
Hermann, Róbert, Soltész, Gyula
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