Antigen-Specific Treg Therapy in Type 1 Diabetes – Challenges and Opportunities
Frontiers in Immunology, 2021 Regulatory T cells (Tregs) are key mediators of peripheral self-tolerance and alterations in their frequencies, stability, and function have been linked to autoimmunity.
Isabelle Serr +7 more
doaj +1 more source
Type 1 diabetes in children [PDF]
, 2013 Many children are not diagnosed early enough.
Kime, NH
core +1 more source
A journey toward an open data culture through transformation of shared data into a data resource
Data & Policy, 2022 The transition to open data practices is straightforward albeit surprisingly challenging to implement largely due to cultural and policy issues. A general data sharing framework is presented along with two case studies that highlight these challenges and
Scott D. Kahn, Anne Koralova
doaj +1 more source
β Cell and Autophagy: What Do We Know?
Biomolecules, 2023 Pancreatic β cells are central to glycemic regulation through insulin production. Studies show autophagy as an essential process in β cell function and fate.
Hamid-Reza Mohammadi-Motlagh +13 more
doaj +1 more source
Recent advances in understanding Type 1 Diabetes [version 1; referees: 2 approved]
F1000Research, 2016 Type 1 diabetes is a multifactorial disease in which genetic and environmental factors play a key role. The triggering event is still obscure, and so are many of the immune events that follow.
Gustaf Christoffersson +2 more
doaj +1 more source
Urinary C-peptide Creatinine Ratio in pregnant women with normal glucose tolerance and type 1 diabetes: evidence for insulin secretion [PDF]
, 2016 Hypothesis In pregnancy, urinary C peptide creatinine ratio (UCPCR) reflects endogenous insulin secretion in women with normal glucose tolerance and type 1 diabetes.
Dornhorst, A +3 more
core +1 more source
Frontiers in Immunology, 2021 In human type 1 diabetes and animal models of the disease, a diverse assortment of immune cells infiltrates the pancreatic islets. CD8+ T cells are well represented within infiltrates and HLA multimer staining of pancreas sections provides clear evidence
Teresa Rodriguez-Calvo +9 more
doaj +1 more source
'Join us on our journey': Exploring the experiences of children and young people with type 1 diabetes and their parents [PDF]
, 2014 This paper focuses on children and young people with type 1 diabetes and on their parents, and their experiences of diabetes care provision. Nine acute hospitals in the Yorkshire and the Humber region, UK, were recruited to participate in a qualitative ...
Department of Health +16 more
core +1 more source
Type 1 diabetes vaccine candidates promote human Foxp3+Treg induction in humanized mice
Nature Communications, 2016 Type 1 diabetes is associated with the loss of self-tolerance to the insulin-producing β-cells in the pancreas. Here the authors show that vaccination with insulin mimetopes can induce human insulin-specific regulatory T cells to mediate tolerance in a ...
Isabelle Serr +11 more
doaj +1 more source
Decline in titers of anti-idiotypic antibodies specific to autoantibodies to GAD65 (GAD65Ab) precedes development of GAD65Ab and type 1 diabetes. [PDF]
PLoS ONE, 2013 The humoral Idiotypic Network consisting of antibodies and their anti-idiotypic antibodies (anti-Id) can be temporarily upset by antigen exposure. In the healthy immune response the original equilibrium is eventually restored through counter-regulatory ...
Helena Elding Larsson +7 more
doaj +1 more source