Results 1 to 10 of about 23,127 (164)

Tiny but powerful: protoplast isolation in Solanum melongena L. and RNPs mediated genome editing [PDF]

Frontiers in Plant Science
Traditional genetic transformation approaches relying on Agrobacterium tumefaciens for the delivery of CRISPR/Cas9 reagents usually provide plants that stably integrate the gene construct in their genome.
Martina Ferrero, Matías Nicolás González, Irene Perrone, Per Hofvander, Mariette Andersson, Andrea Moglia   +5 more
doaj   +2 more sources

Autoantibodies to heterogeneous nuclear ribonucleoproteins

Autoimmunity, 2005
Heterogeneous nuclear ribonucleoproteins (hnRNPs) are among the most abundant proteins in the eukaryotic cell nucleus and play a direct role in several aspects of the RNA life including splicing, export of the mature RNAs and translation. To date, approximately 30 proteins have been identified.
Roberto Caporali, Carlomaurizio Montecucco, Serena Bugatti   +2 more
exaly   +3 more sources

Combined RNA- and DNA-targeting CRISPR ribonucleoproteins enhance suppression of HBV transcripts [PDF]

Frontiers in Genome Editing
IntroductionChronic hepatitis B virus (HBV) infection remains a major global health problem and there is no curative treatment currently available. RNA-targeting CRISPR systems offer a potential alternative to DNA-editing nucleases by enabling direct ...
Puja Banik, Puja Banik, Addison C. Hill, Addison C. Hill, Madison B. Schank, Madison B. Schank, Yi Zhang, Yi Zhang, Juan Zhao, Juan Zhao, Jaeden S. Pyburn, Jaeden S. Pyburn, Holly Orfield, Holly Orfield, Yuezu Wu, Yuezu Wu, Mohammad J. Hajipour, Mohammad J. Hajipour, Mohamed El Gazzar, Mohamed El Gazzar, Shunbin Ning, Shunbin Ning, Jonathan P. Moorman, Jonathan P. Moorman, Jonathan P. Moorman, Zhi Q. Yao, Zhi Q. Yao, Zhi Q. Yao, Ling Wang, Ling Wang   +29 more
doaj   +2 more sources

From development to disease: the neuronal role of hnRNPs through the lens of Drosophila [PDF]

Frontiers in Cell and Developmental Biology
Heterogeneous nuclear ribonucleoproteins (hnRNPs) are a large family of RNA-binding proteins (RBPs) involved in multiple aspects of nucleic acid metabolism, ranging from DNA maintenance to RNA splicing and translation.
Chiara Stefanelli, Davide Colaianni, Cristiano De Pittà, Gabriella M. Mazzotta   +3 more
doaj   +2 more sources

csRNA and heparan sulfate : cell surface ribonucleoproteins regulate HS-mediated signaling [PDF]

Signal Transduction and Targeted Therapy
Jinlin Li, Jiaxin Ling
doaj   +2 more sources

Compendium of Methods to Uncover RNA-Protein Interactions In Vivo

Methods and Protocols, 2021
Control of gene expression is critical in shaping the pro-and eukaryotic organisms’ genotype and phenotype. The gene expression regulatory pathways solely rely on protein–protein and protein–nucleic acid interactions, which determine the fate of the ...
Mrinmoyee Majumder, Viswanathan Palanisamy   +1 more
doaj   +1 more source

Principles of RNA recruitment to viral ribonucleoprotein condensates in a segmented dsRNA virus

eLife, 2023
Rotaviruses transcribe 11 distinct RNAs that must be co-packaged prior to their replication to make an infectious virion. During infection, nontranslating rotavirus transcripts accumulate in cytoplasmic protein-RNA granules known as viroplasms that ...
Sebastian Strauss, Julia Acker, Guido Papa, Daniel Desirò, Florian Schueder, Alexander Borodavka, Ralf Jungmann   +6 more
doaj   +1 more source

Modulation of the Host Nuclear Compartment by Trypanosoma cruzi Uncovers Effects on Host Transcription and Splicing Machinery

Frontiers in Cellular and Infection Microbiology, 2021
Host manipulation is a common strategy for invading pathogens. Trypanosoma cruzi, the causative agent of Chagas Disease, lives intracellularly within host cells.
Camila Gachet-Castro, Felipe Freitas-Castro, Raul Alexander Gonzáles-Córdova, Carol Kobori da Fonseca, Marcelo Damário Gomes, Hellen Cristina Ishikawa-Ankerhold, Munira Muhammad Abdel Baqui   +6 more
doaj   +1 more source

SMN post-translational modifications in spinal muscular atrophy

Frontiers in Cellular Neuroscience, 2023
Since its first identification as the gene responsible for spinal muscular atrophy (SMA), the range of survival motor neuron (SMN) protein functions has increasingly expanded.
Giulietta M. Riboldi, Irene Faravelli, Paola Rinchetti, Francesco Lotti   +3 more
doaj   +1 more source

Noncanonical Functions and Cellular Dynamics of the Mammalian Signal Recognition Particle Components

Frontiers in Molecular Biosciences, 2021
The signal recognition particle (SRP) is a ribonucleoprotein complex fundamental for co-translational delivery of proteins to their proper membrane localization and secretory pathways.
Camilla Faoro, Sandro F. Ataide
doaj   +1 more source