Results 1 to 10 of about 24,238 (294)

The Disruption of the HIV-1 Gag Start Codon via Editing Using MmCas12m-Dual Base Editor-Loaded Virus-like Particles [PDF]

Current Issues in Molecular Biology
Approaches to delivering gene editing tools in the form of ribonucleoproteins may provide a safety advantage over the delivery of nucleic acids encoding ribonucleoproteins. Virus-based vectors are widely used as a delivery platform.
Timur Aliev, Almaz Imatdinov, Elena Prudnikova, Oleg Taranov, Ksenia Emtsova, Ilnaz Imatdinov, Alexander Agafonov   +6 more
doaj   +2 more sources

SHQ1-related hypomyelinating leukodystrophy: A case report with imaging features and a homozygous variant [PDF]

Radiology Case Reports
SHQ1-related hypomyelinating leukodystrophy is an ultra-rare autosomal recessive disorder affecting the assembly of H/ACA ribonucleoproteins, leading to defective myelin formation and progressive neurological impairment.
Abdullah AlBathi, MBBS, Abdullah AlMutairi, MBBS, SB-Rad, Ahmed AlDraihem, MBBS, SB-Rad, Ped SEAP   +2 more
doaj   +2 more sources

From development to disease: the neuronal role of hnRNPs through the lens of Drosophila [PDF]

Frontiers in Cell and Developmental Biology
Heterogeneous nuclear ribonucleoproteins (hnRNPs) are a large family of RNA-binding proteins (RBPs) involved in multiple aspects of nucleic acid metabolism, ranging from DNA maintenance to RNA splicing and translation.
Chiara Stefanelli, Davide Colaianni, Cristiano De Pittà, Gabriella M. Mazzotta   +3 more
doaj   +2 more sources

Compendium of Methods to Uncover RNA-Protein Interactions In Vivo

Methods and Protocols, 2021
Control of gene expression is critical in shaping the pro-and eukaryotic organisms’ genotype and phenotype. The gene expression regulatory pathways solely rely on protein–protein and protein–nucleic acid interactions, which determine the fate of the ...
Mrinmoyee Majumder, Viswanathan Palanisamy   +1 more
doaj   +1 more source

Principles of RNA recruitment to viral ribonucleoprotein condensates in a segmented dsRNA virus

eLife, 2023
Rotaviruses transcribe 11 distinct RNAs that must be co-packaged prior to their replication to make an infectious virion. During infection, nontranslating rotavirus transcripts accumulate in cytoplasmic protein-RNA granules known as viroplasms that ...
Sebastian Strauss, Julia Acker, Guido Papa, Daniel Desirò, Florian Schueder, Alexander Borodavka, Ralf Jungmann   +6 more
doaj   +1 more source

Modulation of the Host Nuclear Compartment by Trypanosoma cruzi Uncovers Effects on Host Transcription and Splicing Machinery

Frontiers in Cellular and Infection Microbiology, 2021
Host manipulation is a common strategy for invading pathogens. Trypanosoma cruzi, the causative agent of Chagas Disease, lives intracellularly within host cells.
Camila Gachet-Castro, Felipe Freitas-Castro, Raul Alexander Gonzáles-Córdova, Carol Kobori da Fonseca, Marcelo Damário Gomes, Hellen Cristina Ishikawa-Ankerhold, Munira Muhammad Abdel Baqui   +6 more
doaj   +1 more source

SMN post-translational modifications in spinal muscular atrophy

Frontiers in Cellular Neuroscience, 2023
Since its first identification as the gene responsible for spinal muscular atrophy (SMA), the range of survival motor neuron (SMN) protein functions has increasingly expanded.
Giulietta M. Riboldi, Irene Faravelli, Paola Rinchetti, Francesco Lotti   +3 more
doaj   +1 more source

Noncanonical Functions and Cellular Dynamics of the Mammalian Signal Recognition Particle Components

Frontiers in Molecular Biosciences, 2021
The signal recognition particle (SRP) is a ribonucleoprotein complex fundamental for co-translational delivery of proteins to their proper membrane localization and secretory pathways.
Camilla Faoro, Sandro F. Ataide
doaj   +1 more source

The Role of RNA Binding Proteins for Local mRNA Translation: Implications in Neurological Disorders

Frontiers in Molecular Biosciences, 2020
As neurons are one of the most highly polarized cells in our body, they require sophisticated cellular mechanisms to maintain protein homeostasis in their subcellular compartments such as axons and dendrites.
Maximilian Paul Thelen, Min Jeong Kye
doaj   +1 more source

Ribonucleoprotein multimers and their functions [PDF]

Critical Reviews in Biochemistry and Molecular Biology, 2010
Ribonucleoproteins (RNPs) play key roles in many cellular processes and often function as RNP enzymes. Similar to proteins, some of these RNPs exist and function as multimers, either homomeric or heteromeric. While in some cases the mechanistic function of multimerization is well understood, the functional consequences of multimerization of other RNPs ...
Franziska, Bleichert, Susan J, Baserga
openaire   +2 more sources