Results 41 to 50 of about 35,404 (208)

Practical guidance for the implementation of the CRISPR genome editing tool in filamentous fungi [PDF]

, 2019
Background: Within the last years, numerous reports described successful application of the CRISPR nucleases Cas9 and Cpf1 for genome editing in filamentous fungi.
Haefner, Stefan, Kwon, Jin, Meyer, Vera, Schütze, Tabea, Spohner, Sebastian   +4 more
core   +1 more source

Activation of Peptidylarginine Deiminase in the Salivary Glands of Balb/c Mice Drives the Citrullination of Ro and La Ribonucleoproteins

Journal of Immunology Research, 2017
The goal of the present study was to determine whether peptidylarginine deiminase PAD2 and PAD4 enzymes are present in Balb/c mouse salivary glands and whether they are able to citrullinate Ro and La ribonucleoproteins.
Mayra Rodríguez-Rodríguez, Rafael Herrera-Esparza, Juan-José Bollain y Goytia, María-Elena Pérez-Pérez, Deyanira Pacheco-Tovar, Jessica Murillo-Vázquez, Guadalupe Pacheco-Tovar, Esperanza Avalos-Díaz   +7 more
doaj   +1 more source

Knocking out barriers to engineered cell activity. [PDF]

, 2020
CRISPR-Cas9 gene-edited T cells show safety and long-term engraftment in ...
Doudna, Jennifer A, Hamilton, Jennifer R
core   +1 more source

Host Factors interacting with the Pestivirus N terminal protease, Npro are Components of the Ribonucleoprotein Complex [PDF]

, 2014
The viral N-terminal protease N(pro) of pestiviruses counteracts cellular antiviral defenses through inhibition of IRF3. Here we used mass spectrometry to identify a new role for N(pro) through its interaction with over 55 associated proteins, mainly ...
A. Donaszi-Ivanov, Anderson, Aratani, Ariumi, Barsnes, Bauhofer, Beckham, Belsham, Bensaude, Borghese, Chatel-Chaix, Chatel-Chaixa, Costa-Mattioli, Cox, Dixit, Doceul, Eisinger-Mathason, Ettema, Fiebach, Fullam, G. Saalbach, Garcia, Gilks, Gorchakov, Haasnoot, Isken, Jefferson, Johns, Kato, Kok, La Rocca, Lawrence, Leung, Li, Liu, Lloyd, M. Jefferson, Meyers, Müller-McNicoll, Netherton, Onishi, P. P. Powell, Panas, Paranjape, Peterhans, Pichlmair, Piotrowska, Robb, Rümenapf, S. Pollen, Sadler, Saunders, Schröder, Szymanski, T. Dalmay, Taylor, Tetsuka, Tetsuka, Tratschin, White, White, Zhang, Zögg   +62 more
core   +1 more source

Cajal body proteins differentially affect the processing of box C/D scaRNPs. [PDF]

PLoS ONE, 2015
Small nuclear ribonucleoproteins (snRNPs), which are required for pre-mRNA splicing, contain extensively modified snRNA. Small Cajal body-specific ribonucleoproteins (scaRNPs) mediate these modifications.
Isioma I Enwerem, Guowei Wu, Yi Tao Yu, Michael D Hebert   +3 more
doaj   +1 more source

Clustering of Rab11 vesicles in influenza A virus infected cells creates hotspots containing the 8 viral ribonucleoproteins [PDF]

, 2016
Influenza A virus is an important human pathogen causative of yearly epidemics and occasional pandemics. The ability to replicate within the host cell is a determinant of virulence, amplifying viral numbers for host-to-host transmission.
Amorim, Maria João, Vale-Costa, Sílvia
core   +1 more source

Conditional ATXN2L-Null in Adult Frontal Cortex CamK2a+ Neurons Does Not Cause Cell Death but Restricts Spontaneous Mobility and Affects the Alternative Splicing Pathway

Cells
The Ataxin-2-like (ATXN2L) protein is required to survive embryonic development, as documented in mice with the constitutive absence of the ATXN2L Lsm, LsmAD, and PAM2 domains due to knock-out (KO) of exons 5–8 with a frameshift.
Jana Key, Luis-Enrique Almaguer-Mederos, Arvind Reddy Kandi, Meike Fellenz, Suzana Gispert, Gabriele Köpf, David Meierhofer, Thomas Deller, Georg Auburger   +8 more
doaj   +1 more source

CRISPR–Cas ribonucleoprotein mediated homology-directed repair for efficient targeted genome editing in microalgae Nannochloropsis oceanica IMET1

Biotechnology for Biofuels, 2019
Background Microalgae are considered as a sustainable feedstock for the production of biofuels and other value-added compounds. In particular, Nannochloropsis spp.
Mihris Ibnu Saleem Naduthodi, Prarthana Mohanraju, Christian Südfeld, Sarah D’Adamo, Maria J. Barbosa, John van der Oost   +5 more
doaj   +1 more source

Heterogeneous nuclear ribonucleoprotein D/AUF1 interacts with heterogeneous nuclear ribonucleoprotein L

Journal of Biosciences, 2007
Heterogeneous nuclear ribonucleoprotein L (hnRNP L) is one of the principal pre-mRNA-binding proteins found in human cells. The hnRNP L protein is fairly abundant. However,it is not restricted to the nucleus, and instead shuttles between the nucleus and the cytoplasm.
Hong-Gyu, Park, Ji-Young, Yoon, Mieyoung, Choi   +2 more
openaire   +2 more sources

Box C/D small nucleolar ribonucleoproteins regulate mitochondrial surveillance and innate immunity.

PLoS Genetics, 2022
Monitoring mitochondrial function is crucial for organismal survival. This task is performed by mitochondrial surveillance or quality control pathways, which are activated by signals originating from mitochondria and relayed to the nucleus (retrograde ...
Elissa Tjahjono, Alexey V Revtovich, Natalia V Kirienko   +2 more
doaj   +1 more source