Results 41 to 50 of about 24,238 (294)

Conditional ATXN2L-Null in Adult Frontal Cortex CamK2a+ Neurons Does Not Cause Cell Death but Restricts Spontaneous Mobility and Affects the Alternative Splicing Pathway

Cells
The Ataxin-2-like (ATXN2L) protein is required to survive embryonic development, as documented in mice with the constitutive absence of the ATXN2L Lsm, LsmAD, and PAM2 domains due to knock-out (KO) of exons 5–8 with a frameshift.
Jana Key, Luis-Enrique Almaguer-Mederos, Arvind Reddy Kandi, Meike Fellenz, Suzana Gispert, Gabriele Köpf, David Meierhofer, Thomas Deller, Georg Auburger   +8 more
doaj   +1 more source

The SMN protein is a key regulator of nuclear architecture in differentiating neuroblastoma cells

, 2009
The cell nucleus contains two closely related structures, Cajal bodies (CBs) and gems. CBs are the first site of accumulation of newly assembled splicing snRNPs (small nuclear ribonucleoproteins) following their import into the nucleus, before they form ...
Nicholas P. Kinnear, Lisa Oram, Julie Burza, Clelland, Allyson K., Oram, Lisa, Allyson K. Clelland, Judith E. Sleeman, Kinnear, Nicholas P., Sleeman, Judith Elizabeth, Burza, Julie   +9 more
core   +1 more source

Heterogeneous Nuclear Ribonucleoproteins: Implications in Neurological Diseases [PDF]

, 2020
Heterogenous nuclear ribonucleoproteins (hnRNPs) are a complex and functionally diverse family of RNA binding proteins with multifarious roles. They are involved, directly or indirectly, in alternative splicing, transcriptional and translational ...
Asi, Y, Low, Y-H, Foti, SC, Lashley, T
core  

Antibody Characterization Report for Heterogeneous nuclear ribonucleoproteins A2/B1 (hnRNP A2/B1)

, 2023
<p>This report presents a guide to selecting high-quality commercial antibodies against Heterogeneous nuclear ribonucleoproteins A2/B1 (hnRNP A2/B1) by immunoblot (Western blot), immunoprecipitation and immunofluorescence, using a knockout based ...
Alende, Charles, McPherson, Peter, Ayoubi, Riham, Fotouhi, Maryam, Reintsch, Wolfgang, Durcan, Thomas, Brown, Claire M., Ryan, Joel, Donovan, Worrall, Laflamme, Carl, Ruíz Moleón, Vera   +10 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Box C/D small nucleolar ribonucleoproteins regulate mitochondrial surveillance and innate immunity.

PLoS Genetics, 2022
Monitoring mitochondrial function is crucial for organismal survival. This task is performed by mitochondrial surveillance or quality control pathways, which are activated by signals originating from mitochondria and relayed to the nucleus (retrograde ...
Elissa Tjahjono, Alexey V Revtovich, Natalia V Kirienko   +2 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

CRISPR–Cas ribonucleoprotein mediated homology-directed repair for efficient targeted genome editing in microalgae Nannochloropsis oceanica IMET1

Biotechnology for Biofuels, 2019
Background Microalgae are considered as a sustainable feedstock for the production of biofuels and other value-added compounds. In particular, Nannochloropsis spp.
Mihris Ibnu Saleem Naduthodi, Prarthana Mohanraju, Christian Südfeld, Sarah D’Adamo, Maria J. Barbosa, John van der Oost   +5 more
doaj   +1 more source

Molecular composition of staufen2-containing ribonucleoproteins in embryonic rat brain. [PDF]

PLoS ONE, 2010
Messenger ribonucleoprotein particles (mRNPs) are used to transport mRNAs along neuronal dendrites to their site of translation. Numerous mRNA-binding and regulatory proteins within mRNPs finely regulate the fate of bound-mRNAs.
Marjolaine Maher-Laporte, Frédéric Berthiaume, Mireille Moreau, Louis-André Julien, Gabriel Lapointe, Michael Mourez, Luc DesGroseillers   +6 more
doaj   +1 more source