Results 61 to 70 of about 25,962 (290)

Highly efficient CRISPR/Cas9‐mediated exon skipping for recessive dystrophic epidermolysis bullosa

Bioengineering & Translational Medicine
Gene therapy based on the CRISPR/Cas9 system has emerged as a promising strategy for treating the monogenic fragile skin disorder recessive dystrophic epidermolysis bullosa (RDEB).
Alex du Rand, John Hunt, Christopher Samson, Evert Loef, Chloe Malhi, Sarah Meidinger, Chun‐Jen Jennifer Chen, Ashley Nutsford, John Taylor, Rod Dunbar, Diana Purvis, Vaughan Feisst, Hilary Sheppard   +12 more
doaj   +1 more source

Box C/D small nucleolar ribonucleoproteins regulate mitochondrial surveillance and innate immunity.

PLoS Genetics, 2022
Monitoring mitochondrial function is crucial for organismal survival. This task is performed by mitochondrial surveillance or quality control pathways, which are activated by signals originating from mitochondria and relayed to the nucleus (retrograde ...
Elissa Tjahjono, Alexey V Revtovich, Natalia V Kirienko   +2 more
doaj   +1 more source

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source

CryoEM of Viral Ribonucleoproteins and Nucleocapsids of Single-Stranded RNA Viruses

Viruses, 2023
Single-stranded RNA viruses (ssRNAv) are characterized by their biological diversity and great adaptability to different hosts; traits which make them a major threat to human health due to their potential to cause zoonotic outbreaks.
Andrea Modrego, Diego Carlero, Rocío Arranz, Jaime Martín-Benito   +3 more
doaj   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Nucleocapsid protein structures from orthobunyaviruses reveal insight into ribonucleoprotein architecture and RNA polymerization [PDF]

, 2013
All orthobunyaviruses possess three genome segments of single-stranded negative sense RNA that are encapsidated with the virus-encoded nucleocapsid (N) protein to form a ribonucleoprotein (RNP) complex, which is uncharacterized at high resolution.
Stonehouse, N. J., al., Et, Ranson, N. A., Hiscox, JA, Matthews, SV, Walter, C. T., Hiscox, J. A., Fooks, Anthony R., Walter, Cheryl T., Shepherd, DA, Ariza, Antonio, Shepherd, D. A., Elliott, R.M., Fooks, AR, Hiscox, Julian A., Dent, KC, Barr, John N., Edwards, T. A., Tanner, SJ, Dent, Kyle C., Matthews, S. V., Shepherd, D.A., Stonehouse, N.J., Barr, J. N., Dent, K.C., Barr, JN, Stonehouse, NJ, Hiscox, J.A., Tanner, S. J., Edwards, T.A., Stonehouse, Nicola J., Dent, K. C., Luo, Ming, Ashcroft, A.E., Shepherd, Dale A., Green, T. J., Ariza, A, Elliott, RM, Elliott, Richard M., Tanner, S.J., Tanner, Sian J., Ariza, A., Wu, W., Edwards, Thomas A., Matthews, Susan V., Ashcroft, Alison E., Wu, W, Green, Todd J., Green, TJ, Walter, C.T., Fooks, A. R., Fooks, A.R., Luo, M, Ashcroft, A. E., Ranson, Neil A., Luo, M., Walter, CT, Elliott, R. M., Green, T.J., Matthews, S.V., Ranson, N.A., Barr, J.N., Ashcroft, AE, Edwards, TA, Ranson, NA, Wu, Weining   +65 more
core   +1 more source

The Nucleolus and the Four Ribonucleoproteins of Translation [PDF]

The Journal of Cell Biology, 2000
The classical view of the nucleolus as solely committed to ribosome biosynthesis has been modified by recent studies pointing to additional roles for this nuclear domain. These newly recognized features include the nucleolar presence of several nonribosomal RNAs transcribed by RNA polymerase III ...
Pederson, Thoru, Politz, Joan C. Ritland
openaire   +3 more sources

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Differential expression of heterogenous nuclear ribonucleoproteins in viral co-infections.

, 2020
Co-infection is a phenomena by which a host or cell is infected by at least two pathogens (1, 2). The severe acute respiratory syndrome coronavirus 2, SARS-CoV-2, has resulted in the death of greater than 200,000 people in the United States in less than
Shahan Mamoor
core   +1 more source

KIF13A mediates influenza a virus ribonucleoproteins trafficking [PDF]

, 2017
The deposited article version contains attached the supplementary materials within the pdf. This publication hasn't any creative commons license associated.
Bárbara Kellen, Silvia Vale-Costa, Ramos-Nascimento, Ana, Ana Ramos-Nascimento, Ferreira, Filipe, Vale-Costa, Silvia, Delevoye, Cédric, Raposo, Graça, Filipe Ferreira, Maria João Amorim, Graça Raposo, Marta Alenquer, Amorim, Maria João, Alenquer, Marta, Cédric Delevoye, Kellen, Bárbara   +15 more
core   +1 more source