Conserved requirement for DEAD-box RNA helicase Gemin3 in Drosophila oogenesis [PDF]
, 2012 Background: DEAD-box RNA helicase Gemin3 is an essential protein since its deficiency is lethal in both vertebrates and invertebrates. In addition to playing a role in transcriptional regulation and RNA silencing, as a core member of the SMN (survival of
Cauchi, Ruben J.
core +3 more sources
Beyond BLASTing : ribonucleoprotein evolution via structural prediction and ancestral sequence reconstruction [PDF]
, 2016 Primary homology in DNA and protein sequence has long been used to infer a relationship between similar sequences. However gene sequence, and thus protein sequence, can change over time.
Daly, Toni K
core
The Cajal body and the nucleolus : “in a relationship” or “it's complicated”? [PDF]
, 2016 From their initial identification as 'nucleolar accessory bodies' more than a century ago, the relationship between Cajal bodies and nucleoli has been a subject of interest and controversy.
Sleeman, Judith E. +1 more
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Nature Communications, 2017 Stress granules (SG) comprise aggregates of cellular messenger ribonucleoproteins (mRNPs) but how they form is unclear. Here, the authors identify NEDD4, an E3 ubiquitin ligase, as regulating the RNA binding protein NANOS2 and turnover of mRNP components,
Zhi Zhou +4 more
doaj +1 more source
New insights into trypanosomatid U5 small nuclear ribonucleoproteins
Memorias do Instituto Oswaldo Cruz, 2011 Several protozoan parasites exist in the Trypanosomatidae family, including various agents of human diseases. Multiple lines of evidence suggest that important differences are present between the translational and mRNA processing (trans splicing) systems
Marco Túlio A da Silva +8 more
doaj +1 more source
NIR is degraded by the anaphase-promoting complex proteasome pathway [PDF]
Archives of Biological Sciences, 2014 Novel INHAT Repressor (NIR) is a histone acetylation inhibitor that can directly bind histone complexes and the tumor suppressors p53 and p63.
Jeong Ho Myong +3 more
doaj +1 more source
PARP-1 dependent recruitment of the amyotrophic lateral sclerosis-associated protein FUS/TLS to sites of oxidative DNA damage [PDF]
, 2013 Amyotrophic lateral sclerosis (ALS) is associated with progressive degeneration of motor neurons. Several of the genes associated with this disease encode proteins involved in RNA processing, including fused-in-sarcoma/translocated-in-sarcoma (FUS/TLS ...
Adamson +53 more
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Efficient DNA-free genome editing of bread wheat using CRISPR/Cas9 ribonucleoprotein complexes
Nature Communications, 2017 Protocols for crop genome editing would ideally be quick, efficient and specific while avoiding integration of transgenes into the genome of edited plants. Here, Lianget al.
Zhen Liang +10 more
doaj +1 more source
Amyloid domains in the cell nucleus controlled by nucleoskeletal protein lamin B1 reveal a new pathway of mercury neurotoxicity [PDF]
PeerJ, 2015 Mercury (Hg) is a bioaccumulating trace metal that globally circulates the atmosphere and waters in its elemental, inorganic and organic chemical forms.
Florian Arnhold +2 more
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Neuronal messenger ribonucleoprotein transport follows an aging Lévy walk
Nature Communications, 2018 The transport dynamics of messenger ribonucleoproteins in neurons is crucial to our neuronal functions, but the detail remains elusive. Song et al. show that they are transported along the dendrites in alternating run and rest phases with their own ...
Minho S. Song +3 more
doaj +1 more source