Results 91 to 100 of about 25,962 (290)

Insights into the function and structure of the R2TP (RUVBL1-RUVBL2-RPAP3-PIH1D1) chaperone complex

Cell Stress & Chaperones
The R2TP chaperone complex comprises two AAA+ proteins, RUVBL1 and RUVBL2, along with RPAP3 and PIH1D1. R2TP functions in concert with other chaperones, such as HSP90 and HSP70, to facilitate the assembly of macromolecular complexes integral to the ...
Maryama Mohamed, Ruikai Wu, Walid A. Houry   +2 more
doaj   +1 more source

Conditionally Significant eQTL and TWAS Analyses Identify MsRD26 as a Major Candidate Positive Regulator of Salt Tolerance in Medicago sativa L

Advanced Science, EarlyView.
Salt stress significantly impacts plant growth. Through population transcriptome, eQTL and TWAS analyses, we identified several candidate genes potentially associated with salt stress response. Functional assays suggested that some of these genes may contribute to salt tolerance.
Lin Chen, Yuqi Zhang, Xinyue Ma, Jinpeng Bi, Fei He, Li Zhao, Haiyue Lei, Zhengqin Xiao, Xue Wang, Tiejun Zhang, Ruicai Long, Junmei Kang, Qingchuan Yang   +12 more
wiley   +1 more source

Pathways of nucleocytoplasmic translocation of ribonucleoproteins. [PDF]

Symposia of the Society for Experimental Biology, 1974
No abstract ...
Franke, Werner W., Scheer, Ulrich
openaire   +1 more source

The role of ribonucleoproteins in the production of mitotic abnormalities

, 1955
Immersion of growing roots of onion and lily in aerated solutions of ribonuclease affected their pattern of growth and altered the structure and mitotic distribution of the chromosomes.
Kaufmann, B. P., Das, N. K.
core   +1 more source

Genetic engineering in primary human B cells with CRISPR-Cas9 ribonucleoproteins [PDF]

, 2018
Genome editing in human cells with targeted nucleases now enables diverse experimental and therapeutic genome engineering applications, but extension to primary human B cells remains limited.
Kristina W. Rosbe, Alexander Marson, Zuniga-Pflucker, Juan Carlos, Marson, Alexander, Wu, Chung-An M, Baglaenko, Yuriy, Dario M. Ferri, Joan E. Wither, Brauer, Patrick, Theodore L. Roth, Patrick Brauer, Roth, Theodore L, Allen, Christopher DC, Christopher D.C. Allen, Chung-An M. Wu, Yuriy Baglaenko, Juan Carlos Zuniga-Pflucker, Ferri, Dario M, Wither, Joan E, Rosbe, Kristina W   +19 more
core   +1 more source

RNA Promotes Synapsin Condensates That Organize Synaptic Vesicles in Live Neurons and Enable Localized Translation in Reconstituted System

Advanced Science, EarlyView.
Condensates at synapses organize synaptic vesicles (SVs) and are crucial for efficient neurotransmitter release, yet how RNA contributes to this mesoscale architecture remains poorly understood. Here we uncover that RNA modulates synapsin–driven condensates.
Branislava Rankovic, Zachary M. Geisterfer, Akshita Chhabra, Vladimir M. Jovanovic, Ian Seim, Christian Hoffmann, Antonela Condric, Gerard Aguilar Pérez, Rinse de Boer, Lars T. Hofstede, Jingao Sun, Kiara Freitag, Katja Nowick, Marina Jendrach, Frank L. Heppner, Vladimir Despic, Michaela Müller‐McNicoll, Stephan Sigrist, Geert van den Bogaart, Sofiia Reshetniak, Amy S. Gladfelter, Dragomir Milovanovic   +21 more
wiley   +1 more source

The Disruption of the HIV-1 Gag Start Codon via Editing Using MmCas12m-Dual Base Editor-Loaded Virus-like Particles

Current Issues in Molecular Biology
Approaches to delivering gene editing tools in the form of ribonucleoproteins may provide a safety advantage over the delivery of nucleic acids encoding ribonucleoproteins. Virus-based vectors are widely used as a delivery platform.
Timur Aliev, Almaz Imatdinov, Elena Prudnikova, Oleg Taranov, Ksenia Emtsova, Ilnaz Imatdinov, Alexander Agafonov   +6 more
doaj   +1 more source

A Cas9 Ribonucleoprotein Platform for Functional Genetic Studies of HIV-Host Interactions in Primary Human T Cells

Cell Reports, 2016
Summary: New genetic tools are needed to understand the functional interactions between HIV and human host factors in primary cells. We recently developed a method to edit the genome of primary CD4+ T cells by electroporation of CRISPR/Cas9 ...
Judd F. Hultquist, Kathrin Schumann, Jonathan M. Woo, Lara Manganaro, Michael J. McGregor, Jennifer Doudna, Viviana Simon, Nevan J. Krogan, Alexander Marson   +8 more
doaj   +1 more source

BOULE is Essential for the Dynamic Disassembly of Heat Shock Granules in Male Germ Cells

Advanced Science, EarlyView.
BOULE orchestrates stress granule disassembly in germ cells via a two‐pronged mechanism: it promotes G3BP1 ubiquitination by upregulating TRIM27, generating a signal for VCP/FAF2 recruitment, and it maintains G3BP1 and FAF2 protein levels. BOULE deficiency disrupts disassembly complex formation, leading to impaired heat shock granule clearance ...
Xin Li, Nana Zhang, Zexin Bian, Baobao Geng, Liyun Cao, Peipei Liu, Zengming Li, Yan Zhao, Jun Tan   +8 more
wiley   +1 more source

The structure of native influenza virion ribonucleoproteins

, 2012
The influenza viruses cause annual epidemics of respiratory disease and occasional pandemics, which constitute a major public-health issue. The segmented negative-stranded RNAs are associated with the polymerase complex and nucleoprotein (NP), forming ...
Conesa, José Javier, Chichón, Francisco Javier, Valpuesta, José M., Ortín, Juan, Martín-Benito, Jaime, Carrascosa, José L, Arranz, Rocío, Coloma, Rocío   +7 more
core   +1 more source