Results 101 to 110 of about 35,404 (208)

Topological barrier to Cas12a activation by circular DNA nanostructures facilitates autocatalysis and transforms DNA/RNA sensing

Nature Communications
Control of CRISPR/Cas12a trans-cleavage is crucial for biosensor development. Here, we show that small circular DNA nanostructures which partially match guide RNA sequences only minimally activate Cas12a ribonucleoproteins.
Fei Deng, Yi Li, Biyao Yang, Rui Sang, Wei Deng, Maya Kansara, Frank Lin, Subotheni Thavaneswaran, David M. Thomas, Ewa M. Goldys   +9 more
doaj   +1 more source

Engineering self-deliverable ribonucleoproteins for genome editing in the brain

Nature Communications
The delivery of CRISPR ribonucleoproteins (RNPs) for genome editing in vitro and in vivo has important advantages over other delivery methods, including reduced off-target and immunogenic effects.
Kai Chen, Elizabeth C. Stahl, Min Hyung Kang, Bryant Xu, Ryan Allen, Marena Trinidad, Jennifer A. Doudna   +6 more
doaj   +1 more source

Modulation of interferon-[alpha] secretion by activated platelets in systemic lupus erythematosus. [PDF]

, 2008
Type I interferons play a key role in systemic lupus erythematosus (SLE) pathogenesis as an "IFN signature" is found in the majority of patients with active SLE.
Bernard Weill, Carole Nicco, Fré, Jean-Franç, Jean-Franç, Jean-Luc Pellegrin, Julien Seneschal, Patrick Blanco, Pierre Duffau   +8 more
core   +1 more source

Ribonucleoprotein [PDF]

, 2020
openaire   +1 more source

Assembly and budding of influenza virus. [PDF]

, 2004
Influenza viruses are causative agents of an acute febrile respiratory disease called influenza (commonly known as "flu") and belong to the Orthomyxoviridae family.
Barman, Subrata, Hui, Eric Ka-Wai, Nayak, Debi P   +2 more
core  

The EV-TRACK summary add-on: integration of experimental information in databases to ensure comprehensive interpretation of biological knowledge on extracellular vesicles [PDF]

, 2020
Dedeyne, Sandor, Hendrix, An, Roux, Quentin, Van Deun, Jan   +3 more
core   +1 more source

Revolutionizing Educational Assessment: The Role of Bing Chat GPT-4 Chatbot in Increasing Efficiency in Grading Open-Ended Questions. [PDF]

Cureus
Abadam-Eremeev D, Seng RP, Srinivasan J, Knouna K, Bogaudo JR, Rodriguez De La Nuez PA, Podcheko A.   +6 more
europepmc   +1 more source

Highlights of the FEBS3+ meeting Exploring molecular frontiers. [PDF]

FEBS Open Bio
Dulić M, Koistinen H, Berntsson R.
europepmc   +1 more source

Intrinsically disordered regions stimulate concentration of small nucleolar ribonucleoproteins and formation of Cajal bodies and nucleoli. [PDF]

Genes Dev
Meznad K, Deogharia M, Wacheul L, Zorbas C, Lafontaine DLJ, Meier UT.   +5 more
europepmc   +1 more source

FAST-CRISPR: Fusogenic Association and Secured Transfection of CRISPR/Cas9 Ribonucleoproteins Using Lipid-Silica Hybrid Nanoparticles for Therapeutic Genome Editing. [PDF]

Small
Kim M, Kim K, Lee J, Lee S, Choi S, Park SA, Jeong E, Choi SY, Park HH, Park TE, Kwon T, Myung K, Yoo J, Cho SW, Joo J.   +14 more
europepmc   +1 more source