Results 81 to 90 of about 24,238 (294)
Neuronal messenger ribonucleoprotein transport follows an aging Lévy walk
Nature Communications, 2018 The transport dynamics of messenger ribonucleoproteins in neurons is crucial to our neuronal functions, but the detail remains elusive. Song et al. show that they are transported along the dendrites in alternating run and rest phases with their own ...
Minho S. Song +3 more
doaj +1 more source
Enhanced NK-92 Cytotoxicity by CRISPR Genome Engineering Using Cas9 Ribonucleoproteins
Frontiers in Immunology, 2020 Natural killer (NK) cells are an attractive cell-type for adoptive immunotherapy, but challenges in preparation of therapeutic primary NK cells restrict patient accessibility to NK cell immunotherapy. NK-92 is a well-characterized human NK cell line that
Rih-Sheng Huang +7 more
doaj +1 more source
The Nucleolus and the Four Ribonucleoproteins of Translation [PDF]
The Journal of Cell Biology, 2000 The classical view of the nucleolus as solely committed to ribosome biosynthesis has been modified by recent studies pointing to additional roles for this nuclear domain. These newly recognized features include the nucleolar presence of several nonribosomal RNAs transcribed by RNA polymerase III ...
Pederson, Thoru, Politz, Joan C. Ritland
openaire +3 more sources
Advanced Science, EarlyView.This study identifies SNRPF as a critical oncogenic driver in ovarian cancer. By regulating a self‐sustaining SNRPF–DDX24–E2F4 feedback loop through intron retention and nonsense‐mediated decay, SNRPF couples RNA splicing with transcriptional regulation to promote tumor progression.
Yingwei Li +4 more
wiley +1 more source
Nature Communications, 2019 A current challenge in genome editing is delivering Cas9 and sgRNA into target cells. Here the authors engineer a delivery system based on murine leukemia virus-like particles loaded with Cas9-sgRNA ribonucleoproteins to induce efficient genome editing ...
Philippe E. Mangeot +18 more
doaj +1 more source
, 1999 The influenza virus genome is transcribed in the nuclei of infected cells but assembled into progeny virions in the cytoplasm. This is reflected in the cellular distribution of the virus nucleoprotein (NP), a protein which encapsidates genomic RNA to ...
Pope, Brian +5 more
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Involvement of heterogeneous nuclear ribonucleoproteins in viral multiplication [PDF]
, 2012 The study of virus-host interactions is a major goal in molecular virology and provides new effective targets for antiviral therapies. Heterogeneous nuclear ribonucleoproteins (hnRNPs) constitute a group of cellular RNA-binding proteins localized ...
Castilla, Viviana, Scolaro, Luis Alberto
core +1 more source
Endogenous Engineering Reprograms Extracellular Vesicles for Enhanced Therapeutic Function
Advanced Science, EarlyView.This review explains how Extracellular vesicles‐producing cells can be endogenously engineered to load therapeutic proteins and nucleic acids. We summarize physiological and genetic strategies that harness native sorting pathways for selective cargo loading.
Jinghui Wang +10 more
wiley +1 more source
Characterization of L1-Ribonucleoprotein Particles [PDF]
, 2016 The LINE-1 retrotransposon (L1) encodes two proteins, ORF1p and ORF2p, which bind to the L1 RNA in cis, forming a ribonucleoprotein (RNP) complex that is critical for retrotransposition. Interactions with both permissive and repressive host factors pervade every step of the L1 life cycle.
Martin S, Taylor +6 more
openaire +2 more sources
The role of ribonucleoproteins in the production of mitotic abnormalities
, 1955 Immersion of growing roots of onion and lily in aerated solutions of ribonuclease affected their pattern of growth and altered the structure and mitotic distribution of the chromosomes.
Kaufmann, B. P., Das, N. K.
core +1 more source