Results 31 to 40 of about 25,962 (290)
Morphology of influenza B/Lee/40 determined by cryo-electron microscopy. [PDF]
PLoS ONE, 2014 Cryo-electron microscopy projection image analysis and tomography is used to describe the overall architecture of influenza B/Lee/40. Algebraic reconstruction techniques with utilization of volume elements (blobs) are employed to reconstruct tomograms of
Garrett Katz +9 more
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Frontiers in Plant Science, 2018 The CRISPR/Cas9 genome editing system has already proved its efficiency, versatility and simplicity in numerous applications in human, animal, microbe and plant cells.
Jana Murovec +4 more
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Loss of function mutations in GEMIN5 cause a neurodevelopmental disorder
Nature Communications, 2021 GEMIN5, an RNA-binding protein, is required for formation of small nuclear ribonucleoproteins. Here, the authors identify loss of function mutations in GEMIN5 that are associated with a human neurodevelopmental disorder.
Sukhleen Kour +69 more
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Proteomic and 3D structure analyses highlight the C/D box snoRNP assembly mechanism and its control [PDF]
, 2014 In vitro, assembly of box C/D small nucleolar ribonucleoproteins (snoRNPs) involves the sequential recruitment of core proteins to snoRNAs. In vivo, however, assembly factors are required (NUFIP, BCD1, and the HSP90–R2TP complex), and it is unknown ...
Franck Vandermoere +32 more
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The SMN protein is a key regulator of nuclear architecture in differentiating neuroblastoma cells [PDF]
, 2009 The cell nucleus contains two closely related structures, Cajal bodies (CBs) and gems. CBs are the first site of accumulation of newly assembled splicing snRNPs (small nuclear ribonucleoproteins) following their import into the nucleus, before they form ...
Nicholas P. Kinnear +9 more
core +1 more source
Nature Communications, 2021 Biogenesis of small nucleolar RNAs ribonucleoproteins (snoRNPs) requires dedicated assembly machinery. Here, the authors show that a subset of snoRNP assembly factors interacts, genetically or directly, with factors modulating chromatin architecture ...
Benoît Bragantini +19 more
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Changes in intranuclear mobility of mature snRNPs provide a mechanism for splicing defects in spinal muscular atrophy [PDF]
, 2012 This work was funded by the Wellcome Trust (grant ID WT078810MA)It is becoming increasingly clear that defects in RNA metabolism can lead to disease. Spinal muscular atrophy (SMA), a leading genetic cause of infant mortality, results from insufficient ...
Clelland, Allyson Kara +2 more
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Preparation of Cas9 Ribonucleoproteins for Genome Editing
Bio-Protocol, 2022 Genome editing by the delivery of pre-assembled Cas9 ribonucleoproteins (Cas9 RNP) is an increasingly popular approach for cell types that are difficult to manipulate genetically by the conventional plasmid and viral methods.
SW Lin, Viet Nguyen, Steven Lin
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Comparative analysis of viral RNA signatures on different RIG-I-like receptors
eLife, 2016 The RIG-I-like receptors (RLRs) play a major role in sensing RNA virus infection to initiate and modulate antiviral immunity. They interact with particular viral RNAs, most of them being still unknown.
Raul Y Sanchez David +10 more
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Heterogeneous Nuclear Ribonucleoproteins: Implications in Neurological Diseases [PDF]
, 2020 Heterogenous nuclear ribonucleoproteins (hnRNPs) are a complex and functionally diverse family of RNA binding proteins with multifarious roles. They are involved, directly or indirectly, in alternative splicing, transcriptional and translational ...
Asi, Y, Low, Y-H, Foti, SC, Lashley, T
core +1 more source