Results 11 to 20 of about 22,188 (264)

Ribonucleoprotein multimers and their functions [PDF]

Critical Reviews in Biochemistry and Molecular Biology, 2010
Ribonucleoproteins (RNPs) play key roles in many cellular processes and often function as RNP enzymes. Similar to proteins, some of these RNPs exist and function as multimers, either homomeric or heteromeric. While in some cases the mechanistic function of multimerization is well understood, the functional consequences of multimerization of other RNPs ...
Franziska, Bleichert, Susan J, Baserga
openaire   +2 more sources

Structure of spliceosomal ribonucleoproteins [PDF]

F1000 Biology Reports, 2010
Splicing of the precursors of eukaryotic mRNA and some non-coding RNAs is catalyzed by the 'spliceosome', which comprises five RNA-protein complexes (small nuclear ribonucleoproteins, or snRNPs) that assemble in an ordered manner onto precursor-mRNAs. Much progress has been made in determining the gross morphology of spliceosomal assembly intermediates.
Krummel, Daniel Aaron Pomeranz, Nagai, Kiyoshi, Oubridge, Chris   +2 more
openaire   +2 more sources

Ribonucleoprotein complexes as autoantigens [PDF]

Current Opinion in Immunology, 1995
Many intracellular proteins and nucleic acids, that are involved in important biosynthetic pathways, are targeted by autoantibodies occurring spontaneously in the sera of patients with systemic autoimmune diseases. Frequently, the autoantigens are assembled into multicomponent complexes containing both nucleic acid(s) and proteins.
Venrooij, W.J. van, Pruijn, G.J.M.
openaire   +3 more sources

Biogenesis of telomerase ribonucleoproteins [PDF]

RNA, 2012
Telomerase adds simple-sequence repeats to the ends of linear chromosomes to counteract the loss of end sequence inherent in conventional DNA replication. Catalytic activity for repeat synthesis results from the cooperation of the telomerase reverse transcriptase protein (TERT) and the template-containing telomerase RNA (TER).
Emily D, Egan, Kathleen, Collins
openaire   +2 more sources

Preparation of B2M and PD-1 Efficiently Double Genes Knock-out Primary Human T Lymphocytes by Cas9 RNP Technology

Zhongliu Fangzhi Yanjiu, 2020
Objective To observe the efficiency of Cas9 RNP technology for the preparation of B2M and PD-1 double genes knock-out primary human T lymphocytes (hereinafter referred to as T cells).
XU Ya, FU Yang, ZHU Shicong, ZHANG Bicheng   +3 more
doaj   +1 more source

Ribonucleoprotein bodies are phased in [PDF]

Biochemical Society Transactions, 2016
Intracellular compartments are necessary for the regulation of many biochemical processes that ensure cell survival, growth and proliferation. Compartmentalisation is commonly achieved in organelles with defined lipid membranes, such as mitochondria, endoplasmic reticulum or the Golgi apparatus. While these organelles are responsible for many localised
Sfakianos, Aristeidis, Whitmarsh, Alan, Ashe, Mark; id_orcid 0000-0002-4457-7851   +2 more
openaire   +2 more sources

The Ribonucleoprotein Csr Network [PDF]

International Journal of Molecular Sciences, 2013
Ribonucleoprotein complexes are essential regulatory components in bacteria. In this review, we focus on the carbon storage regulator (Csr) network, which is well conserved in the bacterial world. This regulatory network is composed of the CsrA master regulator, its targets and regulators.
Seyll, Ethel, Van Melderen, Laurence
openaire   +3 more sources

Morphology of influenza B/Lee/40 determined by cryo-electron microscopy. [PDF]

PLoS ONE, 2014
Cryo-electron microscopy projection image analysis and tomography is used to describe the overall architecture of influenza B/Lee/40. Algebraic reconstruction techniques with utilization of volume elements (blobs) are employed to reconstruct tomograms of
Garrett Katz, Younes Benkarroum, Hui Wei, William J Rice, Doris Bucher, Alexandra Alimova, Al Katz, Joanna Klukowska, Gabor T Herman, Paul Gottlieb   +9 more
doaj   +1 more source

DNA-Free Genome Editing of Brassica oleracea and B. rapa Protoplasts Using CRISPR-Cas9 Ribonucleoprotein Complexes

Frontiers in Plant Science, 2018
The CRISPR/Cas9 genome editing system has already proved its efficiency, versatility and simplicity in numerous applications in human, animal, microbe and plant cells.
Jana Murovec, Katja Guček, Borut Bohanec, Monika Avbelj, Roman Jerala   +4 more
doaj   +1 more source

Loss of function mutations in GEMIN5 cause a neurodevelopmental disorder

Nature Communications, 2021
GEMIN5, an RNA-binding protein, is required for formation of small nuclear ribonucleoproteins. Here, the authors identify loss of function mutations in GEMIN5 that are associated with a human neurodevelopmental disorder.
Sukhleen Kour, Deepa S. Rajan, Tyler R. Fortuna, Eric N. Anderson, Caroline Ward, Youngha Lee, Sangmoon Lee, Yong Beom Shin, Jong-Hee Chae, Murim Choi, Karine Siquier, Vincent Cantagrel, Jeanne Amiel, Elliot S. Stolerman, Sarah S. Barnett, Margot A. Cousin, Diana Castro, Kimberly McDonald, Brian Kirmse, Andrea H. Nemeth, Dhivyaa Rajasundaram, A. Micheil Innes, Danielle Lynch, Patrick Frosk, Abigail Collins, Melissa Gibbons, Michele Yang, Isabelle Desguerre, Nathalie Boddaert, Cyril Gitiaux, Siri Lynne Rydning, Kaja K. Selmer, Roser Urreizti, Alberto Garcia-Oguiza, Andrés Nascimento Osorio, Edgard Verdura, Aurora Pujol, Hannah R. McCurry, John E. Landers, Sameer Agnihotri, E. Corina Andriescu, Shade B. Moody, Chanika Phornphutkul, Maria J. Guillen Sacoto, Amber Begtrup, Henry Houlden, Janbernd Kirschner, David Schorling, Sabine Rudnik-Schöneborn, Tim M. Strom, Steffen Leiz, Kali Juliette, Randal Richardson, Ying Yang, Yuehua Zhang, Minghui Wang, Jia Wang, Xiaodong Wang, Konrad Platzer, Sandra Donkervoort, Carsten G. Bönnemann, Matias Wagner, Mahmoud Y. Issa, Hasnaa M. Elbendary, Valentina Stanley, Reza Maroofian, Joseph G. Gleeson, Maha S. Zaki, Jan Senderek, Udai Bhan Pandey   +69 more
doaj   +1 more source