Results 21 to 30 of about 24,238 (294)
Engineering self-deliverable ribonucleoproteins for genome editing in the brain [PDF]
Nature CommunicationsThe delivery of CRISPR ribonucleoproteins (RNPs) for genome editing in vitro and in vivo has important advantages over other delivery methods, including reduced off-target and immunogenic effects.
Kai Chen +6 more
doaj +2 more sources
, 2021 Induced pluripotent stem cells (iPSCs) have become widely used for disease modelling, particularly with regard to predisposing genetic risk factors and causal gene variants.
Nguyen Tran, Minh Thuan +8 more
core +2 more sources
Structure of spliceosomal ribonucleoproteins [PDF]
F1000 Biology Reports, 2010 Splicing of the precursors of eukaryotic mRNA and some non-coding RNAs is catalyzed by the 'spliceosome', which comprises five RNA-protein complexes (small nuclear ribonucleoproteins, or snRNPs) that assemble in an ordered manner onto precursor-mRNAs. Much progress has been made in determining the gross morphology of spliceosomal assembly intermediates.
Krummel, Daniel Aaron Pomeranz +2 more
openaire +2 more sources
Ribonucleoprotein complexes as autoantigens [PDF]
Current Opinion in Immunology, 1995 Many intracellular proteins and nucleic acids, that are involved in important biosynthetic pathways, are targeted by autoantibodies occurring spontaneously in the sera of patients with systemic autoimmune diseases. Frequently, the autoantigens are assembled into multicomponent complexes containing both nucleic acid(s) and proteins.
Venrooij, W.J. van, Pruijn, G.J.M.
openaire +3 more sources
Biogenesis of telomerase ribonucleoproteins [PDF]
RNA, 2012 Telomerase adds simple-sequence repeats to the ends of linear chromosomes to counteract the loss of end sequence inherent in conventional DNA replication. Catalytic activity for repeat synthesis results from the cooperation of the telomerase reverse transcriptase protein (TERT) and the template-containing telomerase RNA (TER).
Emily D, Egan, Kathleen, Collins
openaire +2 more sources
Sequence alignment, aaTR composition, and predicted structures of Borg Sm ribonucleoproteins.
, 2023 (A) Multiple sequence alignment of Borg Sm ribonucleoproteins with and without aaTRs, Sm from Methanoperedens bins co-occurring with Borgs, and reference sequences from M. jannaschii (PDB: 4X9D), M. nitroreducens (WP_096203417), and E. coli (PDB: 1HK9). (
Rohan Sachdeva (2926581) +4 more
core +1 more source
Ribonucleoprotein bodies are phased in [PDF]
Biochemical Society Transactions, 2016 Intracellular compartments are necessary for the regulation of many biochemical processes that ensure cell survival, growth and proliferation. Compartmentalisation is commonly achieved in organelles with defined lipid membranes, such as mitochondria, endoplasmic reticulum or the Golgi apparatus. While these organelles are responsible for many localised
Sfakianos, Aristeidis +2 more
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Zhongliu Fangzhi Yanjiu, 2020 Objective To observe the efficiency of Cas9 RNP technology for the preparation of B2M and PD-1 double genes knock-out primary human T lymphocytes (hereinafter referred to as T cells).
XU Ya +3 more
doaj +1 more source
The Ribonucleoprotein Csr Network [PDF]
International Journal of Molecular Sciences, 2013 Ribonucleoprotein complexes are essential regulatory components in bacteria. In this review, we focus on the carbon storage regulator (Csr) network, which is well conserved in the bacterial world. This regulatory network is composed of the CsrA master regulator, its targets and regulators.
Seyll, Ethel, Van Melderen, Laurence
openaire +3 more sources
Morphology of influenza B/Lee/40 determined by cryo-electron microscopy. [PDF]
PLoS ONE, 2014 Cryo-electron microscopy projection image analysis and tomography is used to describe the overall architecture of influenza B/Lee/40. Algebraic reconstruction techniques with utilization of volume elements (blobs) are employed to reconstruct tomograms of
Garrett Katz +9 more
doaj +1 more source