Results 81 to 90 of about 11,458 (225)
Chemistry – A European Journal, EarlyView.Lighting up αVβ6: Halotryptophan engineering converts an RGD scaffold into a modular αVβ6 ligand platform, enabling picomolar affinity and late‐stage functionalization. The resulting probes combine high selectivity with fluorescence for FACS and tumor imaging.
Beate Nachtigall +4 more
wiley +1 more source
GPE Analogs and Peptidomimetics
, 2002 This invention relates to analogs and peptidomimetics of glycyl-L-prolyl-L-glutamic acid (GPE). In particular, this invention relates to GPE analogs and peptidomimetics that are anti-apoptotic and anti-necrotic, to methods of making them, to ...
Abood, NA, Brimble, Margaret
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Borylcyclopropanes: Synthetic Strategies and Applications
Angewandte Chemie, Volume 138, Issue 37, 7 September 2026.Borylcyclopropanes (cyclopropanes bearing a boron substituent) sit at the intersection of two privileged frameworks in synthesis. This review provides the first exhaustive survey of their chemistry, spanning metal–carbene, nucleophilic cyclization, radical, hydroboration, and C─H activation routes, and documenting applications in medicinal chemistry ...
Aiza A. Butt, Joseph M. Ready
wiley +2 more sources
European Journal of Organic Chemistry, EarlyView.Diarylethene‐containing cyclic tubulysin analogues were designed, synthesized, and evaluated as light‐responsive cytotoxic agents. One analogue showed reversible photoswitching, photoregulated tubulin polymerization inhibition, and photoform‐dependent cytotoxicity.
Anna Iampolska +9 more
wiley +1 more source
Synthesis and Application of Triazole Containing Peptidomimetics [PDF]
, 2019 Kracker O. Synthesis and Application of Triazole Containing Peptidomimetics.
Kracker, Oliver
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One-Pot High-Throughput Synthesis of β-Turn Cyclic Peptidomimetics via “Volatilizable” Supports
, 2016 A promising method for the high-throughput synthesis of linear C-hydroxyalkylamido peptidomimetics and β-turn cyclic peptidomimetics via “volatilizable” aminoalkyl functionalized silica gels is presented. Boc amino acids and carboxylic acids were coupled
Yangmei Li (322348) +3 more
core +1 more source
Exploring a Ugi‐Mediated Polymerization‐Induced Self‐Assembly Approach to Peptoid Particles
Macromolecular Rapid Communications, EarlyView.Ugi‐mediated polymerization‐induced self‐assembly (U‐PISA) enables the one‐pot synthesis of PEG‐stabilized polypeptoid nanoparticles under mild aqueous conditions. By tuning PEG molar mass and feed composition, tunable spherical and worm‐like nano‐objects are obtained.
Thi Phuong Thu Nguyen +8 more
wiley +1 more source
Characterization of Binding Interactions Between Heparin, and Peptides and Peptidomimetics [PDF]
, 2010 OF THE DISSERTATIONCharacterization of Binding Interactions Between Heparin, and Peptides and PeptidomimeticsByMark HamzaDoctor of Philosophy, Graduate Program in ChemistryUniversity of California, Riverside, June 2010Dr. Dallas L.
Hamza, Mark
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Bio-mimetic strategies to re-activate apoptotic cell death for cancer treatments [PDF]
Exploration of Drug ScienceApoptosis is a crucial process to maintain the correct balance between healthy cells and committed-to-death cells in every tissue. The internal (or mitochondrial) and external (or death receptor) pathways are responsible for driving a series of molecular
Andrea Venerando +2 more
doaj +1 more source
Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future
Medicinal Research Reviews, EarlyView.ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley +1 more source