Results 81 to 90 of about 11,685 (174)
SNAr Cyclizations To Form Cyclic Peptidomimetics of β-Turns
, 2016 SNAr Cyclizations To Form Cyclic Peptidomimetics of β ...
Song Jin (642035) +3 more
core +1 more source
Cyclic Octamer Peptoids: Simplified Isosters of Bioactive Fungal Cyclodepsipeptides
Molecules, 2018 Cyclic peptoids have recently emerged as an important class of bioactive scaffolds with unique conformational properties and excellent metabolic stabilities.
Assunta D’Amato +5 more
doaj +1 more source
Targeting protein–protein interactions with reversible covalent modalities: Non‐cysteine chemistries
British Journal of Pharmacology, Volume 183, Issue 22, Page 6607-6626, November 2026.Abstract Protein–protein interactions (PPIs) are central to diverse cellular functions, and represent a rapidly expanding class of therapeutic targets. Advancements in covalent drug design have enabled small‐molecule drugs to overcome challenges associated with engaging these targets, such as limited durations of action and difficult‐to‐drug (expansive,
Ruchira Basu, Steven Fletcher
wiley +1 more source
GPE Analogs and Peptidomimetics
, 2002 This invention relates to analogs and peptidomimetics of glycyl-L-prolyl-L-glutamic acid (GPE). In particular, this invention relates to GPE analogs and peptidomimetics that are anti-apoptotic and anti-necrotic, to methods of making them, to ...
Abood, NA, Brimble, MA
core
Approaches to the synthesis of ureapeptoid peptidomimetics
, 1997 Ureapeptoid peptidomimetics can be composed from Boc-protected N-substituted ethylenediamines. The best approach is to synthesize these from chloroacetonitrile followed by conversion to the corresponding crystalline p-nitrophenyl carbamates in order to ...
Lefeber, D.J. +2 more
core +1 more source
Development of Bioactive Peptidomimetics
, 2018 Peptidomimetics are synthetic foldamers that expected more resistant to proteolytic degradation and enormous chemodiversity when compared with peptides.
She, Fengyu
core
, 2016 6-Substituted bicyclic thiazolidine lactam peptidomimetics of Pro-Leu-Gly-NH2 (1) were synthesized to test the hypothesis that incorporation of a hydrophobic side chain into the bicyclic thiazolidine lactam scaffold would further enhance the dopamine ...
Rodney L. Johnson (442506) +5 more
core +1 more source
Synthetic receptors based on peptidosulfonamide peptidomimetics
, 1996 We have synthesized tweezer-like receptor molecules based on peptidosulfonamide peptidomimetics. These compounds were screened for binding against a ∼25,000 member encoded tripeptide library.
Shao, Y. +9 more
core +1 more source
Chemistry – A European Journal, Volume 32, Issue 39, 22 October 2026.Hybrid macrocyclic peptides unite genetically encoded peptide libraries with the structural complexity of synthetic small molecules. This Review critically analyzes phage‐compatible cyclization and diversification chemistries, highlights emerging opportunities beyond traditional cysteine‐based approaches, and outlines how future advances may enable the
Titia Rixt Oppewal, Clemens Mayer
wiley +1 more source
Statine-based peptidomimetic compounds as inhibitors for SARS-CoV-2 main protease (SARS-CoV‑2 Mpro)
Scientific ReportsCOVID-19 is a multisystemic disease caused by the SARS-CoV-2 airborne virus, a member of the Coronaviridae family. It has a positive sense single-stranded RNA genome and encodes two non-structural proteins through viral cysteine-proteases processing ...
Pedro Henrique R. de A. Azevedo +18 more
doaj +1 more source