Results 91 to 100 of about 11,685 (174)

Bio-mimetic strategies to re-activate apoptotic cell death for cancer treatments [PDF]

Exploration of Drug Science
Apoptosis is a crucial process to maintain the correct balance between healthy cells and committed-to-death cells in every tissue. The internal (or mitochondrial) and external (or death receptor) pathways are responsible for driving a series of molecular
Andrea Venerando, Denise Lovison, Rossella De Marco   +2 more
doaj   +1 more source

Chelation‐Assisted Metal‐Catalyzed Ligation and Cleavage Reactions for Chemical Biology

European Journal of Organic Chemistry, Volume 29, Issue 39, 22 October 2026.
Chelation‐assisted transition metal catalysis has emerged as a promising complement to bioorthogonal click chemistry for studying biological processes. By pre‐organizing catalytic metal centers, designed coordinating substrates enhance reactivity and biocompatibility, enabling site‐selective ligation and decaging reactions in complex biological media ...
Emilie Plantiveau, Maxime Riberaud, Frédéric Taran, Antoine Sallustrau   +3 more
wiley   +1 more source

Cell adhesive PET membranes by surface grafting of RGD peptidomimetics.

, 2005
A non-peptide mimic of the Arg-Gly Asp (RGD) active sequence of adhesive proteins (such as vitronectin) has been equipped with two different spacer-arms for surface anchorage.
Biltresse, Stéphane, Attolini, Mireille, Marchand-Brynaert, Jacqueline   +2 more
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Phenylalanine-derived β-lactam TRPM8 antagonists: revisiting configuration and new benzoyl derivatives [PDF]

Exploration of Drug Science
Aim: To expand the understanding of the structure-activity relationship within a family of amino acid-derived β-lactam TRPM8 (transient receptor potential melastatin channel, subtype 8) antagonists, this work investigated both the configuration ...
Cristina Martín-Escura, Maria Angeles Bonache, Alicia Medina-Peris, Thomas Voets, Antonio Ferrer-Montiel, Asia Fernández-Carvajal, Rosario González-Muñiz   +6 more
doaj   +1 more source

Hitting Coronaviruses Where It Hurts: Antiviral Strategies Targeting Viral Proteins

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
Viral proteins represent key vulnerabilities in human coronaviruses (HCoVs). This review outlines inhibitors targeting spike (S), main protease (Mpro), papain‐like protease (PLpro), and RNA‐dependent RNA polymerase (RdRp), mapping chemically diverse strategies that disrupt entry and replication, and provides an integrated view of current candidates ...
Álvaro de la Cruz‐Potenciano, Miguel Maldonado, María‐José Camarasa, Sonia de Castro   +3 more
wiley   +1 more source

Cell-free Biosynthesis of Peptidomimetics

, 2023
A wide variety of peptidomimetics (peptide analogs) possessing innovative biological functions have been brought forth as therapeutic candidates through cell-free protein synthesis (CFPS) systems. A key feature of these peptidomimetic drugs is the use of
Lee, Kanghun, Lee, Joongoo, Jewett, Michael C., Kim, Inseon, Willi, Jessica A., Cho, Namjin, Jessica A. Willi, Namjin Cho, Joongoo Lee, Inseon Kim, Michael C. Jewett, Kanghun Lee   +11 more
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PEPITEM, its tripeptide pharmacophores and their peptidomimetic analogues regulate the inflammatory response through parenteral and topical dosing in models of peritonitis and psoriasis

Pharmacological Research
PEPITEM is an immune-modulatory peptide that effectively regulates inflammation and mitigates immune-mediated inflammatory diseases (IMIDs).
Anella Saviano, Bonita Apta, Samantha Tull, Laleh Pezhman, Areeba Fatima, Mustafa Sevim, Antonio Mete, Myriam Chimen, Anna Schettino, Noemi Marigliano, Helen M. McGettrick, Asif J. Iqbal, Francesco Maione, G. Ed Rainger   +13 more
doaj   +1 more source

Use of SH2 STAT3/STAT1 peptidomimetics as anticancer drugs

, 2012
The subject invention concerns compositions and methods for blocking cancer cell growth or proliferation and/or inducing cancer cell death. Compositions of the present invention are peptidomimetics that inhibit STAT function.
Hamilton, Andrew D., Sebti, Said M., Turkson, James, Jove, Richard   +3 more
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Synthesis and Evaluation of Spumigin Analogues Library with Thrombin Inhibitory Activity

Marine Drugs, 2018
Spumigins are marine natural products derived from cyanobacteria Nodularia spumigena, which mimics the structure of the d-Phe-Pro-Arg sequence and is crucial for binding to the active site of serine proteases thrombin and factor Xa. Biological evaluation
Aleš Žula, Izabela Będziak, Danijel Kikelj, Janez Ilaš   +3 more
doaj   +1 more source

Characterization of Binding Interactions Between Heparin, and Peptides and Peptidomimetics [PDF]

, 2010
OF THE DISSERTATIONCharacterization of Binding Interactions Between Heparin, and Peptides and PeptidomimeticsByMark HamzaDoctor of Philosophy, Graduate Program in ChemistryUniversity of California, Riverside, June 2010Dr. Dallas L.
Hamza, Mark
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