Results 101 to 110 of about 10,137 (233)
Pharmacological ResearchPEPITEM is an immune-modulatory peptide that effectively regulates inflammation and mitigates immune-mediated inflammatory diseases (IMIDs).
Anella Saviano +13 more
doaj +1 more source
Synthesis and Evaluation of Spumigin Analogues Library with Thrombin Inhibitory Activity
Marine Drugs, 2018 Spumigins are marine natural products derived from cyanobacteria Nodularia spumigena, which mimics the structure of the d-Phe-Pro-Arg sequence and is crucial for binding to the active site of serine proteases thrombin and factor Xa. Biological evaluation
Aleš Žula +3 more
doaj +1 more source
Chirality, Volume 38, Issue 7, July 2026.A practical and straightforward approach to optically active erythro 3‐amino‐2‐hydroxy acids and its application to the enantioselective synthesis of 3‐phenylisoserine and of the marine natural product 3‐amino‐2‐hydroxy‐6‐methylheptanoic acid is reported.
Marilena Caporale +4 more
wiley +1 more source
Three-Step Synthesis of Cyclopropyl Peptidomimetics
, 2016 An efficient approach to novel cyclopropyl peptidomimetics has been developed. The synthetic route involves a cyclopropanation using ethyl (dimethylsulfuranylidene)acetate (EDSA) as the key step and affords a cyclopropyl peptidomimetic core in three ...
Joseph Reibenspies (2168836) +8 more
core +2 more sources
Bioactive Mimetics of Conotoxins and other Venom Peptides
Toxins, 2015 Ziconotide (Prialt®), a synthetic version of the peptide ω-conotoxin MVIIA found in the venom of a fish-hunting marine cone snail Conus magnus, is one of very few drugs effective in the treatment of intractable chronic pain. However, its intrathecal mode
Peter J. Duggan, Kellie L. Tuck
doaj +1 more source
Pest Management Science, Volume 82, Issue 7, Page 6842-6863, July 2026.A two‐pronged screen of small molecules – (1) on recombinant kinin receptor and (2) through topical application – identifies kinin receptor antagonists, feeding behavior modulators, and new mosquitocidal molecules. Abstract BACKGROUND Aedes aegypti and Culex quinquefasciatus mosquitoes are primary vectors for numerous human and animal pathogens and ...
Bianca M. Henriques‐Santos +1 more
wiley +1 more source
Protein and Peptide Inhibitors of Mineralization: A Systematic Review of In Vitro Studies
Journal of Peptide Science, Volume 32, Issue 7, July 2026.In vitro evidence from crystallization assays demonstrates that peptides inhibit mineral nucleation and crystal growth through sequence‐dependent interactions (acidic residues and phosphorylation) with mineral surfaces. In cell cultures, these molecules reduce calcium deposition and ALP activity and modulate the expression of biomineralization‐related ...
Alberto Mimila‐Cortes +7 more
wiley +1 more source
Nickel Photocatalytic Access to β‐Arylated β‐Amino Acids
Advanced Synthesis &Catalysis, Volume 368, Issue 12, 17 June 2026.Converting naturally abundant amino acids to non‐canonical derivatives in one step under mild conditions allows for improved pharmaceutical properties. Now, this is achieved for β‐arylated β‐amino acids, which are available in good yields directly from aspartic acid, and have the potential to become platform chemicals for drug discovery.
Tim S. Stamp +3 more
wiley +1 more source
European Journal of Organic Chemistry, Volume 29, Issue 23, 16 June 2026.1,1‐Disubstituted vinylbromides are key intermediates for constructing nitrogen‐containing heterocycles. This review provides an overview of the synthetic applications of 1,1‐disubstituted vinylbromides and summarizes recent developments in reaction methodologies, mechanistic insights, and the structural diversity of N‐heterocyclic compounds accessible
Anne Westermeyer +6 more
wiley +1 more source
, 2012 Enzymatically stable cell-penetrating alpha-peptide/beta-peptoid peptidomimetics constitute promising drug delivery vehicles for the transport of therapeutic biomacromolecules across membrane barriers.
Kasimova, Marina R. +10 more
core +1 more source