Results 101 to 110 of about 11,685 (174)
Three-Step Synthesis of Cyclopropyl Peptidomimetics
, 2016 An efficient approach to novel cyclopropyl peptidomimetics has been developed. The synthetic route involves a cyclopropanation using ethyl (dimethylsulfuranylidene)acetate (EDSA) as the key step and affords a cyclopropyl peptidomimetic core in three ...
Joseph Reibenspies (2168836) +8 more
core +2 more sources
Bioactive Mimetics of Conotoxins and other Venom Peptides
Toxins, 2015 Ziconotide (Prialt®), a synthetic version of the peptide ω-conotoxin MVIIA found in the venom of a fish-hunting marine cone snail Conus magnus, is one of very few drugs effective in the treatment of intractable chronic pain. However, its intrathecal mode
Peter J. Duggan, Kellie L. Tuck
doaj +1 more source
The concept of a peptidomimetic was coined about forty years ago. Since then, an enormous effort and interest has been devoted to mimic the properties of peptides with small molecules or pseudopeptides.
Pérez González, Juan Jesús
core
Computer-aided design of amino acid-based therapeutics: a review
Drug Design, Development and Therapy, 2018 Tayebeh Farhadi,1 Seyed MohammadReza Hashemian1,2 1Chronic Respiratory Diseases Research Center (CRDRC), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2Clinical ...
Farhadi T, Hashemian SM
doaj
, 2017 DOPA-derived peptidomimetics are an attractive therapeutic tool for the treatment of Parkinson's disease.
Nicola Berretta +8 more
core +1 more source
Peptidomimetics as a new generation of antimicrobial agents: current progress
Infection and Drug Resistance, 2014 Patricia Méndez-Samperio Department of Immunology, National School of Biological Sciences, National Polytechnic Institute, Mexico City, Mexico Abstract: Antibiotic resistance is an increasing public health concern around the world. Rapid increase
Méndez-Samperio P
doaj
Design and synthesis of CD4 peptidomimetics that inhibit HIV-gp120 binding.
, 1994 Design and synthesis of CD4 peptidomimetics that inhibit HIV-gp120 ...
Savithri. Ramurthy (7959473)
core +3 more sources
Solid-phase synthesis of potential potentantimicrobial peptidomimetics [PDF]
, 2019 The need for alternative therapies becomes more pressing as bacterial infections become re-sistant to antibiotics. Peptides are considered nature’s antibiotic, as their mechanism of antimicro-bial activity either directly kills the infection or ...
Croft, Stephanie Berntsen +2 more
core
Cyclic dipeptide based cell-penetrating peptidomimetics for effective DNA delivery
, 2017 A cyclic dipeptide as an unnatural amino acid employed in the preparation of novel cell penetrating peptidomimetics and their effective DNA delivery is demonstrated.
Chilakapati Madhu +3 more
core +1 more source
Spectrum of activity of the peptidomimetics and standard antibiotics against the ESKAPE pathogens.
, 2019 Spectrum of activity of the peptidomimetics and standard antibiotics against the ESKAPE pathogens.
Brice Felden (7947) +4 more
core +1 more source