Results 31 to 40 of about 2,043,921 (203)
, 2019 A concise synthesis of quinoline-fused eight-membered rings from simple starting materials is described. Reductive cyclo-carbopalladation of suitable Ugi-4CR substrates as a key step leads to the regio- and diastereoselective formation of 1,2 ...
Frank Rominger (63178) +3 more
core +2 more sources
Synthesis of Boron-Containing Primary Amines
Molecules, 2013 In this study, boron-containing primary amines were synthesized for use as building blocks in the study of peptoids. In the first step, Gabriel synthesis conditions were modified to enable the construction of seven different aminomethylphenyl boronate ...
Sheng-Hsuan Chung +4 more
doaj +1 more source
Long-range diastereoselectivity in Ugi reactions of 2-substituted dihydrobenzoxazepines
Beilstein Journal of Organic Chemistry, 2011 The Ugi reaction of 2-substituted dihydrobenzoxazepines was found to proceed with unexpectedly good diastereoselectivitiy (diastereoisomeric ratios up to 9:1), despite the large distance between the pre-existing stereogenic centre and the newly generated
Luca Banfi +4 more
doaj +1 more source
Amide-Stabilized Enols in the Enol-Ugi Reaction: A Five-Component Synthesis of Triamides
Chemistry Proceedings, 2021 In continuation with our research in the use of enols in multicomponent reactions with isocyanides (IMCR), for the first time we have used amide-stabilized enols as the acid component in enol-Ugi reactions.
Ana G. Neo +3 more
doaj +1 more source
Diverse Isoquinoline Scaffolds by Ugi/Pomeranz–Fritsch and Ugi/Schlittler–Müller Reactions [PDF]
Organic Letters, 2019 The Pomeranz-Fritsch reaction and its Schlittler-Müller modification were successfully applied in the Ugi postcyclization strategy by using orthogonally protected aminoacetaldehyde diethyl acetal and complementary electron rich building blocks. Several scaffolds, including isoquinolines, carboline, alkaloid-like tetrazole-fused tetracyclic compounds ...
Yuanze Wang +4 more
openaire +3 more sources
Ugi Multicomponent Reaction Based Synthesis of Medium-Sized Rings [PDF]
, 2017 An Ugi multicomponent reaction based two-step strategy was applied to generate medium-sized rings. In the first linear expansion phase, a series of diamines reacted with cyclic anhydrides to produce different lengths of terminal synthetic amino acids as ...
Rossetti A. +6 more
core +4 more sources
Oxa-Michael/Ugi-Smiles cascade reaction with α,β-unsaturated aldehydes
Results in Chemistry, 2022 Use of α,β-unsaturated aldehydes as components in Ugi-Smiles couplings of 2-nitrophenol with alkyl isocyanides and primary amines provides ready access to γ-alkoxy substituted amides when performed in the presence of alcoholic solvents. The observed five
Aubrey Thessing +5 more
doaj +1 more source
'Atypical Ugi' tetrazoles [PDF]
, 2020 Amino acid-derived isocyano amides together with TMSN3, oxocomponents and 1° or 2° amines are common substrates in the Ugi tetrazole reaction. We surprisingly found that combining these substrates gives two different constitutional isomeric Ugi products ...
Abdelraheem, Eman M M +8 more
core +2 more sources
, 2014 A four-component Ugi reaction (Ugi-4CR) utilizing formylphenyl boronic acids under mild condition was developed for the synthesis of arylboronic acid analogs.
Lian, Ru-Ching; Lin, Meng-Hsuan; Liao, Pin-Hsuan; Fu, Jia-Jie; Wu, Meng-Ju; Wu, Yang-Chang; Chang, Fang-Rong; Wu, Chin-Chung; Pan, Po-Shen +1 more
core +1 more source
Synthesis of Novel Diterpenic Peptides via the Ugi Reaction and Their Anticancer Activities
Molbank, 2023 Novel diterpenic peptide derivatives were synthesized via the Ugi four-component reaction at ambient temperature. The protocol employed a reaction between formaldehyde, benzyl amine, the corresponding diterpene acid, and ethyl 2-isocyanoacetate.
Anna A. Smirnova +3 more
doaj +1 more source