Results 31 to 40 of about 2,155,266 (206)
Macrocyclization of ω‐Isocyano Aldehydes
Angewandte Chemie, EarlyView.The ω‐isocyano aldehydes readily undergo cyclization to afford α‐acyloxy, α‐hydroxy, α‐acetamido, and α‐keto macrolactams, as well as tetrazole‐fused macrocycles, via C(sp3)─C(sp2) bond formation, providing access to diverse α‐functionalized medium‐sized lactams and macrolactams. ABSTRACT Medium‐sized rings and macrocycles constitute a privileged class
Baochao Yang +4 more
wiley +2 more sources
Ugi Multicomponent Reaction Based Synthesis of Medium-Sized Rings [PDF]
, 2017 An Ugi multicomponent reaction based two-step strategy was applied to generate medium-sized rings. In the first linear expansion phase, a series of diamines reacted with cyclic anhydrides to produce different lengths of terminal synthetic amino acids as ...
Eman M. M. Abdelraheem +21 more
core +3 more sources
Oxa-Michael/Ugi-Smiles cascade reaction with α,β-unsaturated aldehydes
Results in Chemistry, 2022 Use of α,β-unsaturated aldehydes as components in Ugi-Smiles couplings of 2-nitrophenol with alkyl isocyanides and primary amines provides ready access to γ-alkoxy substituted amides when performed in the presence of alcoholic solvents. The observed five
Aubrey Thessing +5 more
doaj +1 more source
, 2014 A four-component Ugi reaction (Ugi-4CR) utilizing formylphenyl boronic acids under mild condition was developed for the synthesis of arylboronic acid analogs.
Lian, Ru-Ching; Lin, Meng-Hsuan; Liao, Pin-Hsuan; Fu, Jia-Jie; Wu, Meng-Ju; Wu, Yang-Chang; Chang, Fang-Rong; Wu, Chin-Chung; Pan, Po-Shen +1 more
core +1 more source
Synthesis of Chromeno[3,4-b]piperazines by an Enol-Ugi/Reduction/Cyclization Sequence
Molecules, 2021 Keto piperazines and aminocoumarins are privileged building blocks for the construction of geometrically constrained peptides and therefore valuable structures in drug discovery.
Ana Bornadiego +2 more
doaj +1 more source
Raising the Diversity of Ugi Reactions Through Selective Alkylations and Allylations of Ugi Adducts [PDF]
Frontiers in Chemistry, 2019 We report here selective Tsuji-Trost type allylation of Ugi adducts using a strategy based on the enhanced nucleophilicity of amide dianions. Ugi adducts derived from aromatic aldehydes were easily allylated at their peptidyl position with allyl acetate in the presence of palladium catalysts.
Alaa Zidan +5 more
openaire +4 more sources
SynOpen, 2018 Biologically attractive azaspiro[4.5]trienones have been prepared via Ugi four-component reaction (Ugi-4CR) followed by bromine-mediated ipso-cyclization.
Saeed Balalaie +5 more
doaj +1 more source
Synthesis of Novel Diterpenic Peptides via the Ugi Reaction and Their Anticancer Activities
Molbank, 2023 Novel diterpenic peptide derivatives were synthesized via the Ugi four-component reaction at ambient temperature. The protocol employed a reaction between formaldehyde, benzyl amine, the corresponding diterpene acid, and ethyl 2-isocyanoacetate.
Anna A. Smirnova +3 more
doaj +1 more source
, 2016 The Ugi coupling reaction involves the combination of isocyanide (a), aldehyde (b), amine (c) and carboxylic acid (d) components in a single reaction step to give an α-aminoacyl amide product, as exemplified above for the preparation of AZ126.
Darren S. Heeke (3220149) +13 more
core +1 more source
Beilstein Journal of Organic Chemistry, 2014 An efficient Ugi three-component reaction of a preformed chiral ketimine derived from isatin with various isonitrile and acid components has been developed.
Giordano Lesma +4 more
doaj +1 more source