Results 21 to 30 of about 3,038 (175)
Long-range diastereoselectivity in Ugi reactions of 2-substituted dihydrobenzoxazepines
Beilstein Journal of Organic Chemistry, 2011 The Ugi reaction of 2-substituted dihydrobenzoxazepines was found to proceed with unexpectedly good diastereoselectivitiy (diastereoisomeric ratios up to 9:1), despite the large distance between the pre-existing stereogenic centre and the newly generated
Luca Banfi +4 more
doaj +1 more source
Diverse Isoquinoline Scaffolds by Ugi/Pomeranz–Fritsch and Ugi/Schlittler–Müller Reactions [PDF]
Organic Letters, 2019 The Pomeranz-Fritsch reaction and its Schlittler-Müller modification were successfully applied in the Ugi postcyclization strategy by using orthogonally protected aminoacetaldehyde diethyl acetal and complementary electron rich building blocks. Several scaffolds, including isoquinolines, carboline, alkaloid-like tetrazole-fused tetracyclic compounds ...
Yuanze Wang +4 more
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Oxa-Michael/Ugi-Smiles cascade reaction with α,β-unsaturated aldehydes
Results in Chemistry, 2022 Use of α,β-unsaturated aldehydes as components in Ugi-Smiles couplings of 2-nitrophenol with alkyl isocyanides and primary amines provides ready access to γ-alkoxy substituted amides when performed in the presence of alcoholic solvents. The observed five
Aubrey Thessing +5 more
doaj +1 more source
Raising the Diversity of Ugi Reactions Through Selective Alkylations and Allylations of Ugi Adducts [PDF]
Frontiers in Chemistry, 2019 We report here selective Tsuji-Trost type allylation of Ugi adducts using a strategy based on the enhanced nucleophilicity of amide dianions. Ugi adducts derived from aromatic aldehydes were easily allylated at their peptidyl position with allyl acetate in the presence of palladium catalysts.
Alaa Zidan +5 more
openaire +4 more sources
SynOpen, 2018 Biologically attractive azaspiro[4.5]trienones have been prepared via Ugi four-component reaction (Ugi-4CR) followed by bromine-mediated ipso-cyclization.
Saeed Balalaie +5 more
doaj +1 more source
Synthesis of Novel Diterpenic Peptides via the Ugi Reaction and Their Anticancer Activities
Molbank, 2023 Novel diterpenic peptide derivatives were synthesized via the Ugi four-component reaction at ambient temperature. The protocol employed a reaction between formaldehyde, benzyl amine, the corresponding diterpene acid, and ethyl 2-isocyanoacetate.
Anna A. Smirnova +3 more
doaj +1 more source
Synthesis of Chromeno[3,4-b]piperazines by an Enol-Ugi/Reduction/Cyclization Sequence
Molecules, 2021 Keto piperazines and aminocoumarins are privileged building blocks for the construction of geometrically constrained peptides and therefore valuable structures in drug discovery.
Ana Bornadiego +2 more
doaj +1 more source
Beilstein Journal of Organic Chemistry, 2014 An efficient Ugi three-component reaction of a preformed chiral ketimine derived from isatin with various isonitrile and acid components has been developed.
Giordano Lesma +4 more
doaj +1 more source
Diastereoselective Ugi reaction for the synthesis of unnatural amino esters
Orbital: The Electronic Journal of Chemistry, 2012 Multicomponent Reactions (MCR) are useful reactions to obtain complex products by the simple mixture of 3 or more reactants. The classic Ugi reaction (4-UCR) involves a mixture of an amine, aldehyde, isocyanide and a carboxylic acid, giving peptoides as ...
Rafael Oliveira Rocha +4 more
doaj +1 more source
One‐Pot Synthesis of a Small Synthetic Ligand for Antibody Purification
Biotechnology and Bioengineering, EarlyView.One‐pot liquid‐phase synthesis of the synthetic ligand B1Al2A2 enables controllable ligand density and efficient capture of IgG and IgY with high recovery and purity, streamlining small‐ligand affinity purification workflows. ABSTRACT The development of synthetic affinity ligands offers a cost‐effective alternative to traditional biological ligands ...
Carolina Mota Natal +8 more
wiley +1 more source