Results 21 to 30 of about 4,769 (209)
Ugi Four-Component Reactions Using Alternative Reactants
Molecules, 2023 The Ugi four-component reaction (Ugi-4CR) undoubtedly is the most prominent multicomponent reaction (MCRs) that has sparked organic chemists’ interest in the field.
Seyyed Emad Hooshmand, Wei Zhang
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From Ugi Multicomponent Reaction to Linkers for Bioconjugation [PDF]
ACS Omega, 2020 Bioconjugation is a key approach for the development of novel molecular entities with clinical applications. The biocompatibility and specificity of biomolecules such as peptides, proteins, and antibodies make these macromolecules ideal carriers for selective targeted therapies. In this context, there is a need to develop new molecular units that cover
Iván Ramos-Tomillero +8 more
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Applications of the Ugi reaction with ketones [PDF]
Tetrahedron Letters, 2008 A convenient synthesis of highly functionalized, α,α-disubstituted amino acid amide derivatives has been accomplished by using cyclic and acyclic ketones as the carbonyl inputs in the Ugi multicomponent reaction. An application of this extension of the Ugi reaction to the synthesis of α,α-divinyl amino acids that may be cyclized via ring-closing ...
Suvi T M, Simila, Stephen F, Martin
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ChemistryOpen, 2023 Straightforward and general Passerini and Ugi procedures have been developed to incorporate four‐membered heterocycles into highly functionalized scaffolds.
Gábor Sztanó +2 more
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Beilstein Journal of Organic Chemistry, 2020 In this report, we introduce a new strategy for controlling the stereochemistry in Ugi adducts. Instead of controlling stereochemistry directly during the Ugi reaction we have attempted to stereodefine the chiral center at the peptidyl position through ...
Yuqing Wang +9 more
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Protein-Templated Hit Identification via an Ugi Four-Component Reaction
, 2020 Kinetic target-guided synthesis represents an efficient hit-identification strategy, in which the protein assembles its own inhibitors from a pool of building blocks via an irreversible reaction.
jennifer, herrmann +11 more
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Molecules, 2023 Herein, advanced intermediates were synthesized through Ugi four-component reactions of isocyanides, aldehydes, masked amino aldehyde, and carboxylic acids, including N-protected amino acids.
Naděžda Cankařová, Viktor Krchňák
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Temperature-Controlled Diastereoselective Doebner/Ugi Tandem Reaction
SynOpen, 2023 Novel peptidomimetics containing a pyrrolone fragment were synthesized by a tandem combination of Doebner and Ugi type multicomponent reactions with controlled diastereoselectivity. This approach represents a convenient synthesis in the temperature range
Yana Sakhno +9 more
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Amide-Stabilized Enols in the Enol-Ugi Reaction: A Five-Component Synthesis of Triamides
Chemistry Proceedings, 2021 In continuation with our research in the use of enols in multicomponent reactions with isocyanides (IMCR), for the first time we have used amide-stabilized enols as the acid component in enol-Ugi reactions.
Ana G. Neo +3 more
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, 2019 A concise synthesis of quinoline-fused eight-membered rings from simple starting materials is described. Reductive cyclo-carbopalladation of suitable Ugi-4CR substrates as a key step leads to the regio- and diastereoselective formation of 1,2 ...
Frank Rominger (63178) +3 more
core +2 more sources