Results 21 to 30 of about 2,155,266 (206)

Applications of the Ugi reaction with ketones [PDF]

Tetrahedron Letters, 2008
A convenient synthesis of highly functionalized, α,α-disubstituted amino acid amide derivatives has been accomplished by using cyclic and acyclic ketones as the carbonyl inputs in the Ugi multicomponent reaction. An application of this extension of the Ugi reaction to the synthesis of α,α-divinyl amino acids that may be cyclized via ring-closing ...
Suvi T M, Simila, Stephen F, Martin
openaire   +2 more sources

Exploring a Ugi-Mediated Polymerization-Induced Self-Assembly Approach to Peptoid Particles. [PDF]

Macromol Rapid Commun
Ugi‐mediated polymerization‐induced self‐assembly (U‐PISA) enables the one‐pot synthesis of PEG‐stabilized polypeptoid nanoparticles under mild aqueous conditions. By tuning PEG molar mass and feed composition, tunable spherical and worm‐like nano‐objects are obtained.
Nguyen TPT, Molaro MC, Tien HN, Lei L, Stiernet P, Le Coeur C, Sodano F, Debuigne A, Couturaud B.   +8 more
europepmc   +2 more sources

From Ugi Multicomponent Reaction to Linkers for Bioconjugation [PDF]

ACS Omega, 2020
Bioconjugation is a key approach for the development of novel molecular entities with clinical applications. The biocompatibility and specificity of biomolecules such as peptides, proteins, and antibodies make these macromolecules ideal carriers for selective targeted therapies. In this context, there is a need to develop new molecular units that cover
Iván Ramos-Tomillero, Gema Pérez-Chacon, Beatriz Somovilla-Crespo, Francisco Sánchez-Madrid, Carmen Cuevas, Juan Manuel Zapata, Juan Manuel Domínguez, Hortensia Rodríguez, Fernando Albericio   +8 more
doaj   +6 more sources

'Atypical Ugi' tetrazoles [PDF]

, 2020
Amino acid-derived isocyano amides together with TMSN3, oxocomponents and 1° or 2° amines are common substrates in the Ugi tetrazole reaction. We surprisingly found that combining these substrates gives two different constitutional isomeric Ugi products ...
Abdelraheem, Eman M M, Dömling, Alexander, Goodwin, Imogen, Shaabani, Shabnam, Abdelraheem, Eman M. M., de Haan, Michel P., Kalinowska-Tłuścik, Justyna, Kurpiewska, Katarzyna, de Haan, Michel P   +8 more
core   +1 more source

The Ugi-Smiles Reaction on Steroids: Discovery of Bioactive N,N-Disubstituted 3- Aminoestrones [PDF]

, 2020
The Ugi-Smiles multicomponent reaction is a powerful tool for obtaining N-arylamines from acidic phenols and has been widely used for gaining access to structurally diverse scaffolds. In this work we demonstrate that this isocyanide-based coupling can be
Evelyn, Bonifazi, Javier Alberto, Ramirez, Cecilia, Attorresi, Bruno, Falcone, Gabriel, Gola, Andrea, Barquero   +5 more
core   +1 more source

Highly Substituted Medium-Sized Ring-Fused Azocinoquinoline Scaffolds by Post-Ugi-4CR Reductive Carbopalladation Cyclization

, 2019
A concise synthesis of quinoline-fused eight-membered rings from simple starting materials is described. Reductive cyclo-carbopalladation of suitable Ugi-4CR substrates as a key step leads to the regio- and diastereoselective formation of 1,2 ...
Frank Rominger (63178), Thomas J. J. Müller (7182779), Helya Janatian Ghazvini (7182776), Saeed Balalaie (1754095)   +3 more
core   +2 more sources

Synthesis of Boron-Containing Primary Amines

Molecules, 2013
In this study, boron-containing primary amines were synthesized for use as building blocks in the study of peptoids. In the first step, Gabriel synthesis conditions were modified to enable the construction of seven different aminomethylphenyl boronate ...
Sheng-Hsuan Chung, Ting-Ju Lin, Qian-Yu Hu, Chia-Hua Tsai, Po-Shen Pan   +4 more
doaj   +1 more source

Long-range diastereoselectivity in Ugi reactions of 2-substituted dihydrobenzoxazepines

Beilstein Journal of Organic Chemistry, 2011
The Ugi reaction of 2-substituted dihydrobenzoxazepines was found to proceed with unexpectedly good diastereoselectivitiy (diastereoisomeric ratios up to 9:1), despite the large distance between the pre-existing stereogenic centre and the newly generated
Luca Banfi, Andrea Basso, Valentina Cerulli, Valeria Rocca, Renata Riva   +4 more
doaj   +1 more source

Diverse Isoquinoline Scaffolds by Ugi/Pomeranz–Fritsch and Ugi/Schlittler–Müller Reactions [PDF]

Organic Letters, 2019
The Pomeranz-Fritsch reaction and its Schlittler-Müller modification were successfully applied in the Ugi postcyclization strategy by using orthogonally protected aminoacetaldehyde diethyl acetal and complementary electron rich building blocks. Several scaffolds, including isoquinolines, carboline, alkaloid-like tetrazole-fused tetracyclic compounds ...
Yuanze Wang, Pravin Patil, Katarzyna Kurpiewska, Justyna Kalinowska-Tluscik, Alexander Dömling   +4 more
openaire   +3 more sources

Amide-Stabilized Enols in the Enol-Ugi Reaction: A Five-Component Synthesis of Triamides

Chemistry Proceedings, 2021
In continuation with our research in the use of enols in multicomponent reactions with isocyanides (IMCR), for the first time we have used amide-stabilized enols as the acid component in enol-Ugi reactions.
Ana G. Neo, M. Teresa G. Castellano, José L. Ramiro, Carlos F. Marcos   +3 more
doaj   +1 more source