A Single-Enzyme Activated CRISPR-Cas12a Nano System via Subtly Balanced dsDNA for Kinetic-Gated UDG Detection and Spatiotemporal Cellular Imaging. [PDF]
Adv Sci (Weinh)Kinetic‐gated CRISPR–Cas12a activation enables single‐enzyme detection and spatiotemporal imaging of UDG ABSTRACT Uracil‐DNA glycosylase (UDG) is a key enzyme in base excision repair and an important biomarker for genomic stability and disease. In many reported sensing systems, uracil excision is coupled to signal generation through additional ...
Dong K +12 more
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DFT Studies on the Stereoselective Three-Component Ugi Reaction
Orbital: The Electronic Journal of Chemistry, 2019 Mechanism and stereochemistry of three component Ugi reaction (3C-Ugi) were studied theoretically based on DFT calculations. Structures of reagents, products, intermediates, and transition states were optimized at M062X/6-31+g(d,p) level of theory in gas
Elaheh Sadat Sharifzadeh +1 more
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Unimolecular Exciplexes by Ugi Four-Component Reaction [PDF]
Frontiers in Chemistry, 2019 Exciplex or excited complex emission is an excited state process, arising from considerable charge transfer of an excited energy donor to an acceptor, which can be identified by the occurrence of a redshifted emission band that is absent in the ...
Maria Ochs +3 more
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Beilstein Journal of Organic ChemistryA new tandem sequence involving the Ugi reaction and Diels–Alder [4 + 2] cycloaddition based on vinylfuran and 1,3-butadienylfuran derivatives was designed and studied.
Yuriy I. Horak +5 more
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Diastereoselective Ugi reaction of chiral 1,3-aminoalcohols derived from an organocatalytic Mannich reaction [PDF]
Beilstein Journal of Organic Chemistry, 2016 Enantiomerically pure β-aminoalcohols, produced through an organocatalytic Mannich reaction, were subjected to an Ugi multicomponent reaction under classical or Lewis acid-promoted conditions with diastereoselectivities ranging from moderate to good ...
Samantha Caputo +5 more
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Innovations and Inventions: Why Was the Ugi Reaction Discovered Only 37 Years after the Passerini Reaction? [PDF]
J Org Chem, 2023 This year represents the 100th anniversary of the discovery of the Passerini three-component reaction. The related Ugi four-compound reaction was discovered 37 years after the Passerini reaction.
Dömling A.
europepmc +2 more sources
Insight into the Mechanisms of the Multicomponent Ugi and Ugi–Smiles Reactions by ESI‐MS(/MS)
European Journal of Organic Chemistry, 2014 AbstractThe mechanisms of the Ugi and Ugi–Smiles reactions were investigated by using finely selected reaction conditions that allowed all of the intermediates to be “fish‐out” and characterized by ESI‐MS/MS. New insight into the Ugi and Ugi–Smiles reaction mechanisms is provided without using charge‐tagged reagents.
IACOBUCCI, CLAUDIO +3 more
openaire +2 more sources
Sulfur-Switch Ugi Reaction for Macrocyclic Disulfide-Bridged Peptidomimetics. [PDF]
Org Lett, 2017 A general strategy is introduced for the efficient synthetic access of disulfide linked artificial macrocycles via a Ugi four-component reaction (U4CR) followed by oxidative cyclization.
Vishwanatha TM +2 more
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Ammonia-Promoted One-Pot Tetrazolopiperidinone Synthesis by Ugi Reaction [PDF]
ACS Combinatorial Science, 2017 Pravin Patil +2 more
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Propargyl Amines: Versatile Building Blocks in Post‐Ugi Transformations
ChemistryOpen, 2023 The Ugi reaction, a multicomponent reaction, allows diversity‐oriented synthesis Its importance is recognized by an exponential increase in the publications utilizing the post‐Ugi transformations as a strategy to build complex molecules via simple and ...
Rinkal B. Bhoraniya, Dr. Sachin G. Modha
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