Synthesis of acylhydrazino-peptomers, a new class of peptidomimetics, by consecutive Ugi and hydrazino-Ugi reactions [PDF]
Beilstein Journal of Organic Chemistry, 2016 Herein we describe a versatile approach for the synthesis of acylhydrazino-peptomers, a new class of peptidomimetics. The key idea in this approach is based on a simple route using a one-pot hydrazino-Ugi four-component reaction followed by a ...
Angélica de Fátima S. Barreto +2 more
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Hydrazine in the Ugi tetrazole reaction [PDF]
Synthesis, 2016 We describe the hitherto unknown use of N-Boc-protected hydrazine in the Ugi tetrazole reaction to access a library of highly substituted 5-(hydrazinomethyl)-1-methyl-1H-tetrazoles. The reaction is very versatile and good to high yielding. A one-pot, two-
Patil, Pravin +4 more
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Novel postmodifications of the Ugi reaction [PDF]
, 2016 In dieser Arbeit wurden neuartige Postmodifikationen von Produkten der Ugi-4CR untersucht. Ihre Möglichkeiten und Grenzen wurden durch das Permutieren der notwendigen funktionellen Gruppen um das Ugi-Grundgerüst herum und durch Synthese von ...
Welsch, Sebastian
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α-Ketoglutaric acid in Ugi reactions and Ugi/aza-Wittig tandem reactions
Beilstein Journal of Organic ChemistryA small library of bis- and tetraamides was synthesized by the Ugi reaction with α-ketoglutaric acid, tert-butyl isocyanide, aromatic aldehydes, and aromatic amines.
Vladyslav O. Honcharov +6 more
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Unimolecular Exciplexes by Ugi Four-Component Reaction [PDF]
Frontiers in Chemistry, 2019 Exciplex or excited complex emission is an excited state process, arising from considerable charge transfer of an excited energy donor to an acceptor, which can be identified by the occurrence of a redshifted emission band that is absent in the ...
Maria Ochs +3 more
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DFT Studies on the Stereoselective Three-Component Ugi Reaction [PDF]
Orbital: The Electronic Journal of Chemistry, 2019 Mechanism and stereochemistry of three component Ugi reaction (3C-Ugi) were studied theoretically based on DFT calculations. Structures of reagents, products, intermediates, and transition states were optimized at M062X/6-31+g(d,p) level of theory in gas
Elaheh Sadat Sharifzadeh +1 more
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Innovations and Inventions: Why Was the Ugi Reaction Discovered Only 37 Years after the Passerini Reaction? [PDF]
J Org Chem, 2023 This year represents the 100th anniversary of the discovery of the Passerini three-component reaction. The related Ugi four-compound reaction was discovered 37 years after the Passerini reaction.
Dömling A.
europepmc +2 more sources
Insight into the mechanisms of the multicomponent Ugi and Ugi-Smiles reactions by ESI-MS(/MS)
European Journal of Organic Chemistry, 2014 The mechanisms of the Ugi and Ugi–Smiles reactions were investigated by using finely selected reaction conditions that allowed all of the intermediates to be “fish-out” and characterized by ESI-MS/MS.
Gal, Jean François +3 more
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Sulfur-Switch Ugi Reaction for Macrocyclic Disulfide-Bridged Peptidomimetics. [PDF]
Org Lett, 2017 A general strategy is introduced for the efficient synthetic access of disulfide linked artificial macrocycles via a Ugi four-component reaction (U4CR) followed by oxidative cyclization.
Vishwanatha TM +2 more
europepmc +2 more sources
Protein-Templated Hit Identification via an Ugi Four-Component Reaction [PDF]
, 2020 Kinetic target-guided synthesis represents an efficient hit-identification strategy, in which the protein assembles its own inhibitors from a pool of building blocks via an irreversible reaction.
jennifer, herrmann +11 more
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