Results 51 to 60 of about 2,043,921 (203)

One‐Pot Synthesis of a Small Synthetic Ligand for Antibody Purification

Biotechnology and Bioengineering, EarlyView.
One‐pot liquid‐phase synthesis of the synthetic ligand B1Al2A2 enables controllable ligand density and efficient capture of IgG and IgY with high recovery and purity, streamlining small‐ligand affinity purification workflows. ABSTRACT The development of synthetic affinity ligands offers a cost‐effective alternative to traditional biological ligands ...
Carolina Mota Natal, Catarina Domingos, André Nascimento, José Mendes, Afonso B. Ruiz, Ana Margarida Gonçalves Carvalho Dias, Luisa M. Ferreira, Cristina Peixoto, Ana Cecília Afonso Roque   +8 more
wiley   +1 more source

Ugi-Functionalized Magnetic Carbon Quantum Dots: an Efficient and Environmentally Friendly Catalyst for the Synthesis of 1,4-Dihydropyridines

Journal of Science: Advanced Materials and Devices
This research presents the synthesis of Ugi-modified magnetic carbon quantum dots (MCQD-AP-Ugi) via a one-pot process to improve functionality. For the first time, the Ugi reaction was utilized to modify the surface of carbon quantum dots (CQDs), thereby
Faezeh Montazeri, Robabeh Baharfar, Behrooz Maleki   +2 more
doaj   +1 more source

Hybrid Macrocyclic Peptides — Synthetic Strategies to Diversify and Cyclize Peptide Libraries in Phage Display Selections

Chemistry – A European Journal, EarlyView.
Hybrid macrocyclic peptides unite genetically encoded peptide libraries with the structural complexity of synthetic small molecules. This Review critically analyzes phage‐compatible cyclization and diversification chemistries, highlights emerging opportunities beyond traditional cysteine‐based approaches, and outlines how future advances may enable the
Titia Rixt Oppewal, Clemens Mayer
wiley   +1 more source

Endoscopic features of cytomegalovirus disease of the upper gastrointestinal tract between transplant and non-transplant patients [PDF]

The Korean Journal of Internal Medicine
Background/Aims Cytomegalovirus (CMV) disease in the upper gastrointestinal (UGI) tract frequently occurs in immunocompromised patients. However, data regarding UGI CMV disease in non-transplant patients compared with those in transplant recipients are ...
Yuri Kim, Do Hoon Kim, Myeongsook Seo, Hee Kyong Na, Kee Wook Jung, Ji Yong Ahn, Jeong Hoon Lee, Kee Don Choi, Ho June Song, Gin Hyug Lee, Hwoon-Yong Jung   +10 more
doaj   +1 more source

Influence of Open Chain and Cyclic Structure of Peptidomimetics on Antibacterial Activity in E. coli Strains

Molecules, 2022
An efficient method for the synthesis of functionalized peptidomimetics via multicomponent Ugi reaction has been developed. The application of trifluoroethanol (TFE) as a reaction medium provided desired products with good yields.
Parul Sahrawat, Paweł Kowalczyk, Dominik Koszelewski, Mateusz Szymczak, Karol Kramkowski, Aleksandra Wypych, Ryszard Ostaszewski   +6 more
doaj   +1 more source

Protein-Templated Hit Identification through an Ugi Four-Component Reaction. [PDF]

, 2020
Kinetic target-guided synthesis represents an efficient hit-identification strategy, in which the protein assembles its own inhibitors from a pool of complementary building blocks via an irreversible reaction. Herein, we pioneered an in situ Ugi reaction
Jumde, Varsha R, Blankenfeldt, Wulf, Müller, Rolf, Mancini, Federica, Alaa Alhayek, Unver, M Yagiz, Elgaher, Walid A M, Witte, Martin D, Varsha R. Jumde, Rolf Müller, Hirsch, Anna K.H., Witte, Martin D., Köck, Matthias, Federica Mancini, M. Yagiz Unver, Unver, M. Yagiz, Jennifer Herrmann, Wulf Blankenfeldt, Peer Lukat, Matthias Köck, Hirsch, Anna K H, Martin D. Witte, Anna K. H. Hirsch, Alhayek, Alaa, Witte, Martin D.; id_orcid, Lukat, Peer, Herrmann, Jennifer, Walid A. M. Elgaher, Jumde, Varsha R., Elgaher, Walid A.M.   +29 more
core   +2 more sources

Diarylethene‐Containing Photoswitchable Analogues of Tubulysins—Design, Synthesis, Biological, and Structural Evaluation

European Journal of Organic Chemistry, EarlyView.
Diarylethene‐containing cyclic tubulysin analogues were designed, synthesized, and evaluated as light‐responsive cytotoxic agents. One analogue showed reversible photoswitching, photoregulated tubulin polymerization inhibition, and photoform‐dependent cytotoxicity.
Anna Iampolska, Sergii Afonin, Oleg Babii, Mahri Park, Juan Estévez‐Gallego, Michel O. Steinmetz, Andrea E. Prota, Anne S. Ulrich, David R. Spring, Igor V. Komarov   +9 more
wiley   +1 more source

Synthesis of β‐ and γ‐Carbolinones Through a Fe(III)‐Mediated Radical 6‐Endo‐Trig Cyclization of Indole‐Based Ugi 4‐CR Adducts

European Journal of Organic Chemistry, EarlyView.
A practical strategy for synthesizing β‐ and γ‐carbolinones from indole‐based Ugi 4‐CR adducts through an intramolecular radical cyclization using Fe(III)–H species is presented. This approach enables the efficient synthesis of spiro‐carbolinones under mild reaction conditions and demonstrates the effectiveness of secondary radicals in both cyclization
María F. Olvera‐Granados, Luis A. Polindara‐García   +1 more
wiley   +1 more source

Cage-like microstructures via sequential Ugi reactions in aqueous emulsions

Beilstein Journal of Organic Chemistry
Cage-like microstructures were obtained in two steps by sequential Ugi reactions. At the first stage, submicron colloidal particles based on carboxymethylcellulose and chitosan with a domain structure were obtained in an aqueous suspension. In the second
Rita S. Alqubelat, Yaroslava A. Menzorova, Maxim A. Mironov   +2 more
doaj   +1 more source

Microwave-assisted efficient and facile synthesis of tetramic acid derivatives via a one-pot post-Ugi cascade reaction

Beilstein Journal of Organic Chemistry, 2020
A facile microwave-assisted method for the synthesis of tetramic acid derivatives has been developed through an Ugi/Dieckmann cyclization strategy with DBU.
Yong Li, Zheng Huang, Jia Xu, Yong Ding, Dian-Yong Tang, Jie Lei, Hong-yu Li, Zhong-Zhu Chen, Zhi-Gang Xu   +8 more
doaj   +1 more source