Results 71 to 80 of about 10,504 (214)

Engineering Compact Base Editors by AlphaFold‐Guided Mutation Scan and Escherichia coli‐Based Tri‐Selection

Advanced Science, Volume 13, Issue 20, 9 April 2026.
A miniaturized deaminase SsdAtox was scanned with AlphaFold to identify DNA binding pocket hot spots. Site‐saturation mutagenesis at gatekeeper residue K31 yielded ten‐fold activity enhancement. Trinity Screen, an E. coli‐based three‐in‐one platform selecting for high activity and reduced double‐strand breaks, enabled combinatorial evolution at DNA ...
Ryeo Gang Son, Goeun Kim, Jungjoon K. Lee   +2 more
wiley   +1 more source

In Silico and in Vitro Studies of Fluorinated Chroman-2-Carboxilic Acid Derivatives as an Anti-tubercular Agent

Folia Medica, 2018
Background: Despite the use of traditional method, Ugi reaction currently is a well-established multicomponent reaction. Chromane motif itself possesses a variety of biological functions.
Kapadiya Khushal M., Jadeja Yashwantsinh S., Banik Avishek, Khunt Ranjan C.   +3 more
doaj   +1 more source

Ionic-Liquid-Supported Synthesis of Amines and Derivatives [PDF]

, 2006
International audienceAmine precursors such as glycines protected at nitrogen with a Boc or formyl group were grafted by esterification on the hydroxylated arms of 1-(2-hydroxyethyl)-3-methylimidazolium hexafluorophosphates or tetrafluoroborates.
Bazureau, J.P., Debdab, Mansour, Mongin, Florence   +2 more
core   +4 more sources

Perforated Gastric Ulcer due to a Giant Trichobezoar: A Case Report and Literature Review

Clinical Case Reports, Volume 14, Issue 4, April 2026.
ABSTRACT The term “trichobezoar” refers to foreign and indigestible material in the gastrointestinal tract, and it can indicate several underlying mental illnesses. A 38‐year‐old woman reported experiencing sudden intensive abdominal pain, along with a two‐month history of vomiting, nausea, exhaustion, and abdominal discomfort.
Raghad Samha, Fadi Tabara, Howida Daghestani, Kristin Alsalami, Marah Mansour, Yasmin Martini, Abdulsalam Koushe, Youmna Stitieh, Abdulrahman Almarzouki, Riad Alhamaidi   +9 more
wiley   +1 more source

Synthesis, Characterization and Chemistry of Tetrakis(Propargylisocyanide) Copper(I) Complex

Molbank, 2023
The kinetically unstable propargylisocyanide was reacted with the tetrakis(acetonitrile) copper(I) hexafluorophosphate and the formed complex was then involved in a copper-catalyzed alkyne-azide cycloaddition reaction (CuAAC). After the decomplexation of
Alexandre Quelhas, Thierry Roisnel, Jean-Claude Guillemin, Yann Trolez   +3 more
doaj   +1 more source

Study of High Energy Heavy-Ion Collisions in a Relativistic BUU-Approach with Momentum-Dependent Mean-Fields

, 1993
We introduce momentum-dependent scalar and vector fields into the Lorentz covariant relativistic BUU- (RBUU-) approach employing a polynomial ansatz for the relativistic nucleon-nucleon interaction. The momentum-dependent parametrizations are shown to be
Aichelin, Aichelin, Aichelin, Alard, Batko, Batko, Bertsch, Blattel, Botermans, Cassing, Cassing, Cassing, Cassing Wolfgang, Clark, Cugnon, Danielewicz, Fuchs, Gale, Grosse, Gutbrod, Hama, Henning, Herrmann, Jung, Ko, Ko, Lang, Lang, Lang, Li, Li, Li, Maruyama, Maruyama, Maruyama Tomoyuki, Mosel, Mosel Ulrich, Nagamiya, Sehn, Senger, Serot, Stock, Stocker, Teis Stefan, Tjon, Weber, Weber, Weber Klaus, Wong, Xiong   +49 more
core   +1 more source

Copper‐ and Silver‐Catalyzed Reactions of Active Methylene Isocyanides: Facile Access to Highly Substituted Five‐ and Six‐Membered Heterocycles

Chemistry – A European Journal, Volume 32, Issue 13, 1 April 2026.
This review summarizes recent advances in copper‐ and silver‐catalyzed reactions of active methylene isocyanides for the synthesis of highly substituted five‐ and six‐membered heterocycles. Emphasis is placed on [3+n] cycloadditions, annulations, and asymmetric strategies, highlighting current limitations and future opportunities in heterocycle ...
Jimil George, Kyungsoo Oh
wiley   +1 more source

Phosphoranaloga von Aminosäuren und Peptiden: β-Lactam-Grundgerüst mit Aminomethylphosphonsäure

CHIMIA, 1984
Syntheses of β-lactams containing aminomethylphosphonate involving the Ugi-reaction of diethylisocyanmethylphosphonate 4 with carbonyl compounds 3 and β-alanine are reported.
Janusz Rachoń
doaj   +1 more source

A Novel Class of Small Molecule Agonists with Preference for Human over Mouse TLR4 Activation. [PDF]

PLoS ONE, 2016
The best-characterized Toll-like receptor 4 (TLR4) ligands are lipopolysaccharide (LPS) and its chemically modified and detoxified variant, monophosphoryl lipid A (MPL).
Jason D Marshall, Darren S Heeke, Eileen Rao, Sean K Maynard, David Hornigold, Christopher McCrae, Neil Fraser, Andrey Tovchigrechko, Li Yu, Nicola Williams, Sarah King, Martin E Cooper, Adeline M Hajjar, Jennifer C Woo   +13 more
doaj   +1 more source

Vedolizumab Induces Remission in Two Cases of Ulcerative Colitis With Upper Gastrointestinal Involvement

DEN Open, Volume 6, Issue 1, April 2026.
ABSTRACT Ulcerative colitis (UC) predominantly affects the colon; upper gastrointestinal involvement (UGI) has been reported, but no established treatments exist. We report two cases of UC with concomitant UGI that showed positive responses to vedolizumab therapy.
Shinya Nakatani, Yuta Yamazaki, Kensuke Higuchi, Yumi Otoyama, Norihiro Suzuki, Kazuo Kikuchi, Takahisa Fujiwara, Atsushi Katagiri, Jyun Ohara, Hitoshi Yoshida   +9 more
wiley   +1 more source