Results 71 to 80 of about 4,769 (209)
Digestive Endoscopy, Volume 38, Issue 5, May 2026.ABSTRACT Objectives Artificial intelligence (AI)‐assisted endoscopy has been developed for the early detection of upper gastrointestinal cancer; however, its clinical effectiveness remains insufficiently evaluated. This study assessed its effectiveness in a health screening facility.
Chihiro Goto +10 more
wiley +1 more source
Cleavable β-Cyanoethyl Isocyanide in the Ugi Tetrazole Reaction [PDF]
Organic Letters, 2016 β-Cyanoethyl isocyanide is introduced as a cleavable isocyanide in the Ugi tetrazole reaction. Eleven examples are described that exhibit a broad scope and are obtained in good overall yields. The obtained 1H-tetrazole scaffold is an important bioisostere for carboxylic acids, and the method described here is a valuable alternative route to known ...
Kroon +4 more
openaire +3 more sources
Phosphoranaloga von Aminosäuren und Peptiden: β-Lactam-Grundgerüst mit Aminomethylphosphonsäure
CHIMIA, 1984 Syntheses of β-lactams containing aminomethylphosphonate involving the Ugi-reaction of diethylisocyanmethylphosphonate 4 with carbonyl compounds 3 and β-alanine are reported.
Janusz Rachoń
doaj +1 more source
A Novel Class of Small Molecule Agonists with Preference for Human over Mouse TLR4 Activation. [PDF]
PLoS ONE, 2016 The best-characterized Toll-like receptor 4 (TLR4) ligands are lipopolysaccharide (LPS) and its chemically modified and detoxified variant, monophosphoryl lipid A (MPL).
Jason D Marshall +13 more
doaj +1 more source
The Multifaceted Legacy of Thalidomide: Chemistry and Biology Driving Modern Drug Design
ChemMedChem, Volume 21, Issue 7, 14 April 2026.Thalidomide serves as a molecular nexus linking chemistry and biology: advances in synthesis and structural understanding enable protein degradation technologies, while its immunomodulatory activity underpins anti‐inflammatory and anticancer therapies.
Konstantina Nikovia +4 more
wiley +1 more source
ChemPhysChem, Volume 27, Issue 7, 14 April 2026.The development of effective strategies for the detoxification of organophosphorus (OP) nerve agents has evolved from the early mechanistic studies of François Terrier and collaborators, who first elucidated the exceptional nucleophilicity of α‐effect species such as oximes and hydroxamates, to the modern design of supramolecular and material‐based ...
Pedro Rodríguez‐Dafonte
wiley +1 more source
‐heterocycles Using the Ugi Four‐Center Three‐Component Reaction
, 2019 Ugi four-center three-component reaction (U-4 C-3CR) as actually an important development of the well-known Ugi four-component reaction (U-4CR). In U-4 C-3CR, one of the components is bifunctional, reducing the components of U-4CR to three components ...
M Heravi; Majid +3 more
core +1 more source
Beilstein Journal of Organic Chemistry, 2017 Isocyanide-based multicomponent reactions (IMCRs) allow the construction of relatively complex molecules through a one-pot synthesis. The combination of IMCRs in a consecutive or sequential fashion further extends the complexity of the molecules obtained.
Angélica de Fátima S. Barreto +2 more
doaj +1 more source
Advanced Science, Volume 13, Issue 20, 9 April 2026.A miniaturized deaminase SsdAtox was scanned with AlphaFold to identify DNA binding pocket hot spots. Site‐saturation mutagenesis at gatekeeper residue K31 yielded ten‐fold activity enhancement. Trinity Screen, an E. coli‐based three‐in‐one platform selecting for high activity and reduced double‐strand breaks, enabled combinatorial evolution at DNA ...
Ryeo Gang Son +2 more
wiley +1 more source
Perforated Gastric Ulcer due to a Giant Trichobezoar: A Case Report and Literature Review
Clinical Case Reports, Volume 14, Issue 4, April 2026.ABSTRACT The term “trichobezoar” refers to foreign and indigestible material in the gastrointestinal tract, and it can indicate several underlying mental illnesses. A 38‐year‐old woman reported experiencing sudden intensive abdominal pain, along with a two‐month history of vomiting, nausea, exhaustion, and abdominal discomfort.
Raghad Samha +9 more
wiley +1 more source