Results 71 to 80 of about 2,155,266 (206)

Hybrid Macrocyclic Peptides — Synthetic Strategies to Diversify and Cyclize Peptide Libraries in Phage Display Selections

Chemistry – A European Journal, Volume 32, Issue 39, 22 October 2026.
Hybrid macrocyclic peptides unite genetically encoded peptide libraries with the structural complexity of synthetic small molecules. This Review critically analyzes phage‐compatible cyclization and diversification chemistries, highlights emerging opportunities beyond traditional cysteine‐based approaches, and outlines how future advances may enable the
Titia Rixt Oppewal, Clemens Mayer
wiley   +1 more source

Synthesis of seven-membered nitrogen heterocycles through the Ugi multicomponent reaction

, 2017
This paper reviews all the syntheses of 7-membered nitrogen heterocycles that are based on the Ugi multicomponent reaction. Different systems may be obtained in a diversity-oriented manner employing three general strategies: i) intramolecular Ugi ...
LAMBRUSCHINI, CHIARA, BANFI, LUCA, RIVA, RENATA, BASSO, ANDREA, MONI, LISA   +4 more
core   +1 more source

Triterpenoid bis-Amide Analogs via the Ugi Reaction

Chemistry Proceedings
Isocyanide-based multicomponent reactions, such as the Ugi four-component reaction, are among the most relevant synthetic tools in modern organic chemistry.
Fidel Rodriguez-López, Cristian Saldana-Arredondo, Hugo A. García-Gutiérrez, Rocío Gámez-Montaño   +3 more
doaj   +1 more source

Phosphoranaloga von Aminosäuren und Peptiden: β-Lactam-Grundgerüst mit Aminomethylphosphonsäure

CHIMIA, 1984
Syntheses of β-lactams containing aminomethylphosphonate involving the Ugi-reaction of diethylisocyanmethylphosphonate 4 with carbonyl compounds 3 and β-alanine are reported.
Janusz Rachoń
doaj   +1 more source

A Novel Class of Small Molecule Agonists with Preference for Human over Mouse TLR4 Activation. [PDF]

PLoS ONE, 2016
The best-characterized Toll-like receptor 4 (TLR4) ligands are lipopolysaccharide (LPS) and its chemically modified and detoxified variant, monophosphoryl lipid A (MPL).
Jason D Marshall, Darren S Heeke, Eileen Rao, Sean K Maynard, David Hornigold, Christopher McCrae, Neil Fraser, Andrey Tovchigrechko, Li Yu, Nicola Williams, Sarah King, Martin E Cooper, Adeline M Hajjar, Jennifer C Woo   +13 more
doaj   +1 more source

FeIII‐Mediated Synthesis of Azaspirodienones via Ipso‐Radical Cyclization of Ugi–4CR Adducts

European Journal of Organic Chemistry, Volume 29, Issue 39, 22 October 2026.
An efficient two‐step protocol for the synthesis of azaspirodienones via Fe‐mediated ipso‐radical cyclization of Ugi adducts has been developed. This methodology provides rapid access to these privileged spirocyclic architectures under mild conditions, offering a practical and versatile approach to generating structurally complex molecules with ...
Silvia J. Becerra–Anaya, Valeria Morales–Hernández, Luis A. Polindara–García   +2 more
wiley   +1 more source

Synthesis of β‐ and γ‐Carbolinones Through a Fe(III)‐Mediated Radical 6‐Endo‐Trig Cyclization of Indole‐Based Ugi 4‐CR Adducts

European Journal of Organic Chemistry, Volume 29, Issue 38, 13 October 2026.
A practical strategy for synthesizing β‐ and γ‐carbolinones from indole‐based Ugi 4‐CR adducts through an intramolecular radical cyclization using Fe(III)–H species is presented. This approach enables the efficient synthesis of spiro‐carbolinones under mild reaction conditions and demonstrates the effectiveness of secondary radicals in both cyclization
María F. Olvera‐Granados, Luis A. Polindara‐García   +1 more
wiley   +1 more source

Unlocking the potential of post-synthetic modifications in covalent organic frameworks via the Ugi reaction [PDF]

The present dissertation describes the development and applications of a new post-synthetic modification (PSM) strategy via the Ugi multicomponent reaction in crystalline, porous, organic solids known as Covalent Organic Frameworks (COFs). The novelty of
Volkov, Alexander
core   +1 more source

Synthesis and Activity‐Based Protein Profiling Identifies Aldo‐Keto Reductase 1C3 as Target Protein of Myxoglucamides

Angewandte Chemie International Edition, Volume 65, Issue 41, 5 October 2026.
Myxoglucamide A—a novel glycolipopeptide isolated from myxobacteria—was synthesized, and activity‐based protein profiling identified aldo‐keto reductase 1C3 (AKR1C3) as its main target in human cells. Structure‐activity relationship studies, together with biophysical characterization and X‐ray crystallography, elucidated the structural basis of AKR1C3 ...
Thomas Siemon, Vivek K. Mishra, Mingming Zhao, Konrad Büssow, Alexander Popoff, Chengzhang Fu, Rolf Müller, Lothar Jänsch, Wulf Blankenfeldt, Mark Brönstrup   +9 more
wiley   +1 more source

Synthesis of Quinoxalin-2(1H)-One Derivatives via the Novel Ugi 4CR, Followed by Palladium-Catalyzed Cyclization Process

Chemistry Proceedings
A novel synthetic methodology has been developed for the efficient preparation of Quinoxalin-2(1H)-one derivatives through a strategically designed combination of Ugi four-component reaction (4CR) followed by metal-catalyzed cross-coupling reactions ...
Murali Venkata Basavanag Unnamatla, Rocío Gámez Montaño, Laurent El Kaïm   +2 more
doaj   +1 more source