Results 71 to 80 of about 2,043,921 (203)
Molecular Basis for Uracil‐DNA‐Glycosylase to Identify DNA Damage in the Nucleosome
Proteins: Structure, Function, and Bioinformatics, EarlyView.ABSTRACT The DNA base‐excision repair (BER) pathway is initiated by a glycosylase, such as uracil‐DNA‐glycosylase (UDG), which identifies and removes a wrong base incorporated in the DNA sequence. The very early steps in the identification of the DNA damage are crucial to the correct initiation of the repair chain, and become even more complex when ...
Safwen Ghediri +2 more
wiley +1 more source
Acta Paediatrica, EarlyView.ABSTRACT Aim The aim of this study was to assess the clinical implications of upper gastrointestinal (UGI) involvement in paediatric inflammatory bowel disease (IBD). Methods This retrospective cohort study included children diagnosed with IBD between 2010 and 2023, who underwent a UGI endoscopic evaluation at diagnosis and were followed for at least ...
Ofek Aloni +8 more
wiley +1 more source
Folia Medica, 2018 Background: Despite the use of traditional method, Ugi reaction currently is a well-established multicomponent reaction. Chromane motif itself possesses a variety of biological functions.
Kapadiya Khushal M. +3 more
doaj +1 more source
Angewandte Chemie International Edition, Volume 65, Issue 36, 1 September 2026.Tetrazoles are reframed as substitution‐programmable heterocycles rather than static functional groups in polymer chemistry. By linking electronic identity to synthetic strategy and polymer architecture, this mini‐review establishes a design framework for translating tetrazole duality into predictable macromolecular function.
Meryem S. Akdemir, Hatice Mutlu
wiley +1 more source
Triterpenoid bis-Amide Analogs via the Ugi Reaction
Chemistry ProceedingsIsocyanide-based multicomponent reactions, such as the Ugi four-component reaction, are among the most relevant synthetic tools in modern organic chemistry.
Fidel Rodriguez-López +3 more
doaj +1 more source
Phosphoranaloga von Aminosäuren und Peptiden: β-Lactam-Grundgerüst mit Aminomethylphosphonsäure
CHIMIA, 1984 Syntheses of β-lactams containing aminomethylphosphonate involving the Ugi-reaction of diethylisocyanmethylphosphonate 4 with carbonyl compounds 3 and β-alanine are reported.
Janusz Rachoń
doaj +1 more source
A Novel Class of Small Molecule Agonists with Preference for Human over Mouse TLR4 Activation. [PDF]
PLoS ONE, 2016 The best-characterized Toll-like receptor 4 (TLR4) ligands are lipopolysaccharide (LPS) and its chemically modified and detoxified variant, monophosphoryl lipid A (MPL).
Jason D Marshall +13 more
doaj +1 more source
‐heterocycles Using the Ugi Four‐Center Three‐Component Reaction
, 2019 Ugi four-center three-component reaction (U-4 C-3CR) as actually an important development of the well-known Ugi four-component reaction (U-4CR). In U-4 C-3CR, one of the components is bifunctional, reducing the components of U-4CR to three components ...
M Heravi; Majid +3 more
core +1 more source
Strategies and mechanisms of precision genome engineering: From gene editing to genome writing
iMetaOmics, Volume 3, Issue 3, September 2026.In this review, we examined the progression of genome manipulation from stochastic nuclease‐mediated cutting toward precise editing and programmable genome writing. We discussed tools like multi‐kilobase RNA‐guided integrators and Artificial Intelligence (AI)‐designed effectors and showed how these advances enable researchers to treat genomes as ...
Kerui Huang +19 more
wiley +1 more source
Model Studies on the First Enzyme-Catalyzed Ugi Reaction
, 2016 Multicomponent reactions are powerful tools for organic chemistry, and among them, the Ugi reaction provides remarkable improvement in many fields of organic chemistry such us combinatorial chemistry, medicinal chemistry, and peptide chemistry.
Stanisław Berłożecki (1997758) +3 more
core +1 more source