Results 81 to 90 of about 4,769 (209)
Chemistry – A European Journal, Volume 32, Issue 13, 1 April 2026.This review summarizes recent advances in copper‐ and silver‐catalyzed reactions of active methylene isocyanides for the synthesis of highly substituted five‐ and six‐membered heterocycles. Emphasis is placed on [3+n] cycloadditions, annulations, and asymmetric strategies, highlighting current limitations and future opportunities in heterocycle ...
Jimil George, Kyungsoo Oh
wiley +1 more source
DEN Open, Volume 6, Issue 1, April 2026.ABSTRACT Ulcerative colitis (UC) predominantly affects the colon; upper gastrointestinal involvement (UGI) has been reported, but no established treatments exist. We report two cases of UC with concomitant UGI that showed positive responses to vedolizumab therapy.
Shinya Nakatani +9 more
wiley +1 more source
Model Studies on the First Enzyme-Catalyzed Ugi Reaction
, 2016 Multicomponent reactions are powerful tools for organic chemistry, and among them, the Ugi reaction provides remarkable improvement in many fields of organic chemistry such us combinatorial chemistry, medicinal chemistry, and peptide chemistry.
Stanisław Berłożecki (1997758) +3 more
core +1 more source
Stricturing Diseases of the Gastrointestinal Tract—Current Clinical Practice
JGH Open, Volume 10, Issue 4, April 2026.ABSTRACT Gastrointestinal stricture can occur in the esophagus, stomach, small intestine, colon, and anorectum. Most of the strictures are benign. The prevalence of esophageal strictures (ES) secondary to eosinophilic esophagitis has increased. Pyloric stenosis (PS) is rarely seen in clinical practice.
Monjur Ahmed
wiley +1 more source
Journal of Cellular and Molecular Medicine, Volume 30, Issue 8, April 2026.ABSTRACT CRISPR‐Cas9 systems revolutionized gene editing, but inherent drawbacks, namely DNA double‐strand breaks (DSBs) and the difficulty of achieving precise repairs (due to low HDR efficiency), led researchers to invent new, more accurate gene editing tools.
Melike Aliciaslan +3 more
wiley +1 more source
Addressing Malnutrition in Australian Hospitals: A Scoping Review to Inform Systems Thinking
Journal of Human Nutrition and Dietetics, Volume 39, Issue 2, April 2026.151 total studies included in the review. 49.8% at risk of malnutrition. 34.6% were diagnosed as malnourished. The results show that improvements in the management of malnutrition will come from changing the system through a collaborative approach with the wider multidisciplinary team. ABSTRACT Malnutrition is a common issue in healthcare settings and,
Jolie Baird +4 more
wiley +1 more source
Application of the Ugi Reaction for the One-Pot Synthesis of Uracil Polyoxin C Analogues
, 2016 A simple, two-step synthesis of amide derivatives of uracil polyoxin C (UPOC) methyl ester using the Ugi reaction is described. The four components employed in the Ugi reaction are 2′,3′-isopropylidine-protected uridine-5′-aldehyde, 2,4 ...
Andrew Plant (2320891) +2 more
core +1 more source
Synthesis of 4-azasteroids by an intramolecular Ugi reaction
Steroids, 2008 In this paper we report the use of an intramolecular Ugi reaction to synthesize new 4-azacholestanes diversely substituted both at N-4 and C-5. Both the scope and the stereochemical outcome of this approach were studied by varying the nature of the components necessary for this multicomponent reaction.
Alonso, Fernando +3 more
openaire +3 more sources
, 2019 Here we report an organocatalytic double Ugi reaction combining the enantioselective process and ee enhancement in a single operation to afford the chiral Ugi products with very high ee values.
Mei-Xiang Wang +7 more
core +1 more source
Doebner-type pyrazolopyridine carboxylic acids in an Ugi four-component reaction
Beilstein Journal of Organic Chemistry, 2019 Substituted 1H-pyrazolo[3,4-b]pyridine-4- and 1H-pyrazolo[3,4-b]pyridine-6-carboxamides have been synthetized through a Doebner–Ugi multicomponent reaction sequence in a convergent and versatile manner using diversity generation strategies: combination ...
Maryna V. Murlykina +11 more
doaj +1 more source