Results 81 to 90 of about 2,043,921 (203)

Smart Design: Integrating Artificial Intelligence and Gene Editing for Advanced mRNA Therapeutics

MedComm – Biomaterials and Applications, Volume 5, Issue 3, September 2026.
The challenges of mRNA therapy and the application of artificial intelligence and gene editing in the field of mRNA drugs. ABSTRACT Artificial intelligence (AI) and gene editing are increasingly being applied to the design and evaluation of mRNA therapeutics.
Haixing Shi, Shengbin Liu, Danni Dai, Shanhui Jiang, Tingchen Tian, Zhenyi Niu, Zhongzheng Xiang, Chaoyu Zou, Fang Liu, Xue Tang, Xin Jiang, Xiangrong Song   +11 more
wiley   +1 more source

Synthesis of Quinoxalin-2(1H)-One Derivatives via the Novel Ugi 4CR, Followed by Palladium-Catalyzed Cyclization Process

Chemistry Proceedings
A novel synthetic methodology has been developed for the efficient preparation of Quinoxalin-2(1H)-one derivatives through a strategically designed combination of Ugi four-component reaction (4CR) followed by metal-catalyzed cross-coupling reactions ...
Murali Venkata Basavanag Unnamatla, Rocío Gámez Montaño, Laurent El Kaïm   +2 more
doaj   +1 more source

Consecutive hydrazino-Ugi-azide reactions: synthesis of acylhydrazines bearing 1,5-disubstituted tetrazoles

Beilstein Journal of Organic Chemistry, 2017
Isocyanide-based multicomponent reactions (IMCRs) allow the construction of relatively complex molecules through a one-pot synthesis. The combination of IMCRs in a consecutive or sequential fashion further extends the complexity of the molecules obtained.
Angélica de Fátima S. Barreto, Veronica Alves dos Santos, Carlos Kleber Z. Andrade   +2 more
doaj   +1 more source

Safety and Efficacy of Vedolizumab for the Patients With Gastrointestinal Acute Graft‐Versus‐Host Disease Refractory to Steroid Treatment After Allogeneic Hematopoietic Stem Cell Transplantation: A Real‐World, Retrospective Multicenter Study (VAST Study)

MedComm, Volume 7, Issue 9, September 2026.
This multicenter, real‐world study with a large sample size (i.e., vedolizumab for aGVHD refractory to steroid treatment, VAST study) was designed to identify the safety and efficacy of vedolizumab treatment in patients with steroid‐refractory gastrointestinal acute graft‐versus‐host disease (SR‐GI‐aGVHD). The overall response rates (ORR) on day 28 and
Leqing Cao, Yi Xia, Song Xue, Jianping Zhang, Jiameng Li, Yuewen Wang, Qi Wen, Ze Tian, Jun Kong, Daoxing Deng, Xiaohui Zhang, Yang Cao, Na Xu, Xiaodong Mo   +13 more
wiley   +1 more source

Synthesis of seven-membered nitrogen heterocycles through the Ugi multicomponent reaction

, 2017
This paper reviews all the syntheses of 7-membered nitrogen heterocycles that are based on the Ugi multicomponent reaction. Different systems may be obtained in a diversity-oriented manner employing three general strategies: i) intramolecular Ugi ...
LAMBRUSCHINI, CHIARA, BANFI, LUCA, RIVA, RENATA, BASSO, ANDREA, MONI, LISA   +4 more
core   +1 more source

Reporting of colorectal anastomotic leakage: Worldwide audit of national databases

Colorectal Disease, Volume 28, Issue 9, September 2026.
Abstract Aim Reporting of colorectal anastomotic leakage (CAL) risk factors and outcomes is not standardized worldwide. This study searched a cohort of national surgical registries to assess the scope of CAL‐related elements that are routinely reported. Methods This international audit was conducted between June 2025 and April 2026.
Anne de Wit, Freek Daams, Katherine Lam, Katherine Donovan, Daniela Ramos‐Delgado, Danique J. I. Heuvelings, Nicole D. Bouvy, Nader Francis, Marylise Boutros, Patricia Sylla   +9 more
wiley   +1 more source

Retro‐Hetero‐Michael Addition Strategies in Organic Synthesis

European Journal of Organic Chemistry, Volume 29, Issue 32, 24 August 2026.
In this review, synthetic approaches to carbo‐ and heterocyclic compounds, including natural products, published in the last 15 years (2011–2025) which have either relied upon or included a retro‐hetero‐Michael addition step at any stage are discussed.
Dina Scarpi, Ernesto G. Occhiato
wiley   +1 more source

Deactivation Pathways in 2‐Ferrocenylmethyl‐5‐Aminoxazoles Synthesized via Ugi–Zhu Reaction: A Dewar–Chatt–Duncanson‐Type Interaction

ChemistrySelect, Volume 11, Issue 29, 3 August 2026.
The synthesis and full characterization are reported of 15 new ferrocenyl‐containing oxazoles via the Ugi–Zhu reaction, which is a special kind of MCR versatile to synthesize different types of heterocycles and polyheterocycles, and the DFT‐based study is performed using a high level of theory to rationalize the reactivity of synthesized compounds ...
Carlos E. Garduño‐Albino, Roberto E. Blanco‐Carapia, Ricardo Alfredo Luna‐Mora, Humberto Laguna‐Galindo, Eduardo González‐Zamora, Alejandro Islas‐Jácome   +5 more
wiley   +1 more source

Architecturally diverse proteins converge on an analogous mechanism to inactivate Uracil-DNA glycosylase [PDF]

, 2013
Uracil-DNA glycosylase (UDG) compromises the replication strategies of diverse viruses from unrelated lineages. Virally encoded proteins therefore exist to limit, inhibit or target UDG activity for proteolysis.
Cole, Ambrose R., Savva, Renos, Baltulionis, Gediminas, Ofer, S, Hornyak, P, Ryzhenkova, K, Baltulionis, G, Cole, AR, Ofer, Sapir, Savva, R, Ryzhenkova, Ksenia, Hornyak, Peter   +11 more
core   +1 more source

Application of the Ugi Reaction for the One-Pot Synthesis of Uracil Polyoxin C Analogues

, 2016
A simple, two-step synthesis of amide derivatives of uracil polyoxin C (UPOC) methyl ester using the Ugi reaction is described. The four components employed in the Ugi reaction are 2′,3′-isopropylidine-protected uridine-5′-aldehyde, 2,4 ...
Andrew Plant (2320891), Peter Thompson (165468), David M. Williams (16225)   +2 more
core   +1 more source