Results 61 to 70 of about 10,504 (214)

Ugi-Functionalized Magnetic Carbon Quantum Dots: an Efficient and Environmentally Friendly Catalyst for the Synthesis of 1,4-Dihydropyridines

Journal of Science: Advanced Materials and Devices
This research presents the synthesis of Ugi-modified magnetic carbon quantum dots (MCQD-AP-Ugi) via a one-pot process to improve functionality. For the first time, the Ugi reaction was utilized to modify the surface of carbon quantum dots (CQDs), thereby
Faezeh Montazeri, Robabeh Baharfar, Behrooz Maleki   +2 more
doaj   +1 more source

Reversal of diastereoselectivity in the synthesis of Peptidomimetic 3‑Carboxamide-1,4-benzodiazepin-5-ones [PDF]

, 2015
Enantiopure 3-carboxamide-1,4-benzodiazepin-5-ones were synthesized via the Ugi reaction followed by the Staudinger/aza-Wittig or reduction reactions in only two steps. A complete reversal of diastereoselectivity was achieved depending on the cyclization
Corres, Nazaret, García Valverde, María, Pertejo Fernández, Pablo, Torroba Pérez, Tomás   +3 more
core   +1 more source

Predictive Value of Nutrition Indices in Advanced Hepatocellular Carcinoma Patients Treated With Lenvatinib

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT The prognostic nutritional index (PNI) and geriatric nutritional risk index (GNRI) are simple markers that reflect immune and nutritional status. This retrospective study evaluated their prognostic significance in 276 patients with advanced hepatocellular carcinoma (HCC) who received first‐line lenvatinib. PNI and GNRI were calculated based on
Cheng‐Wei Kuo, Wei‐Chen Tai, Yen‐Hao Chen, Ming‐Chao Tsai, Jing‐Houng Wang, Sheng‐Nan Lu, Tsung‐Hui Hu, Chao‐Hung Hung, Chien‐Hung Chen, Yuan‐Hung Kuo   +9 more
wiley   +1 more source

Post-Ugi Cyclization for the Construction of Diverse Heterocyclic Compounds: Recent Updates

Frontiers in Chemistry, 2018
Multicomponent reactions (MCRs) have proved as a valuable tool for organic and medicinal chemist because of their ability to introduce a large degree of chemical diversity in the product in a single step and with high atom economy.
Jitender Bariwal, Rupinder Kaur, Leonid G. Voskressensky, Erik V. Van der Eycken, Erik V. Van der Eycken   +4 more
doaj   +1 more source

Impact of Artificial Intelligence‐Assisted Endoscopy on Screening for Upper Gastrointestinal Cancer in a Large‐Scale Health Screening Facility

Digestive Endoscopy, Volume 38, Issue 5, May 2026.
ABSTRACT Objectives Artificial intelligence (AI)‐assisted endoscopy has been developed for the early detection of upper gastrointestinal cancer; however, its clinical effectiveness remains insufficiently evaluated. This study assessed its effectiveness in a health screening facility.
Chihiro Goto, Ryo Nakagawa, Ryosuke Horio, Akane Kurosugi, Tatsuya Kaneko, Tsubasa Ishikawa, Yuki Ohta, Takashi Taida, Kenichiro Okimoto, Tomoaki Matsumura, Jun Kato   +10 more
wiley   +1 more source

Synthesis of polyampholyte microgels from colloidal salts of pectinic acid and their application as pH-responsive emulsifiers [PDF]

, 2013
A novel method for obtaining cross-linked microgels of apple pectin has been introduced. This method is based on the Ugi four-component condensation in colloidal suspensions of pectinic acid and amines.
Bakulev, V. A., Mironov, M. A., Ponomarev, V. S., Shulepov, I. D.   +3 more
core   +1 more source

The Multifaceted Legacy of Thalidomide: Chemistry and Biology Driving Modern Drug Design

ChemMedChem, Volume 21, Issue 7, 14 April 2026.
Thalidomide serves as a molecular nexus linking chemistry and biology: advances in synthesis and structural understanding enable protein degradation technologies, while its immunomodulatory activity underpins anti‐inflammatory and anticancer therapies.
Konstantina Nikovia, Michael Kapsalis, Michael Georgoulakis, Athanasios Panousis, Constantinos G. Neochoritis   +4 more
wiley   +1 more source

Cage-like microstructures via sequential Ugi reactions in aqueous emulsions

Beilstein Journal of Organic Chemistry
Cage-like microstructures were obtained in two steps by sequential Ugi reactions. At the first stage, submicron colloidal particles based on carboxymethylcellulose and chitosan with a domain structure were obtained in an aqueous suspension. In the second
Rita S. Alqubelat, Yaroslava A. Menzorova, Maxim A. Mironov   +2 more
doaj   +1 more source

From Mechanisms to Materials: Oximate Reactivity and Emerging Strategies for Organophosphate Detoxification

ChemPhysChem, Volume 27, Issue 7, 14 April 2026.
The development of effective strategies for the detoxification of organophosphorus (OP) nerve agents has evolved from the early mechanistic studies of François Terrier and collaborators, who first elucidated the exceptional nucleophilicity of α‐effect species such as oximes and hydroxamates, to the modern design of supramolecular and material‐based ...
Pedro Rodríguez‐Dafonte
wiley   +1 more source

Advances of Ugi reaction in natural product synthesis

Green Synthesis and Catalysis
The Ugi multicomponent reaction represents a highly efficient synthetic transformation, wherein all four reactants (isocyanides, amine, aldehyde or ketone and a nucleophile) are combined in one pot under mild conditions. This reaction exhibits remarkable
Wen Zhang, Pei Tang, Mohamed Aamer Abubaker, Guo-Hua Hu, Fen-Er Chen   +4 more
doaj   +1 more source