Results 61 to 70 of about 2,043,921 (203)

FeIII‐Mediated Synthesis of Azaspirodienones via Ipso‐Radical Cyclization of Ugi–4CR Adducts

European Journal of Organic Chemistry, EarlyView.
An efficient two‐step protocol for the synthesis of azaspirodienones via Fe‐mediated ipso‐radical cyclization of Ugi adducts has been developed. This methodology provides rapid access to these privileged spirocyclic architectures under mild conditions, offering a practical and versatile approach to generating structurally complex molecules with ...
Silvia J. Becerra–Anaya, Valeria Morales–Hernández, Luis A. Polindara–García   +2 more
wiley   +1 more source

Advances of Ugi reaction in natural product synthesis

Green Synthesis and Catalysis
The Ugi multicomponent reaction represents a highly efficient synthetic transformation, wherein all four reactants (isocyanides, amine, aldehyde or ketone and a nucleophile) are combined in one pot under mild conditions. This reaction exhibits remarkable
Wen Zhang, Pei Tang, Mohamed Aamer Abubaker, Guo-Hua Hu, Fen-Er Chen   +4 more
doaj   +1 more source

Post-Ugi Cyclization for the Construction of Diverse Heterocyclic Compounds: Recent Updates

Frontiers in Chemistry, 2018
Multicomponent reactions (MCRs) have proved as a valuable tool for organic and medicinal chemist because of their ability to introduce a large degree of chemical diversity in the product in a single step and with high atom economy.
Jitender Bariwal, Rupinder Kaur, Leonid G. Voskressensky, Erik V. Van der Eycken, Erik V. Van der Eycken   +4 more
doaj   +1 more source

1,3,4-Oxadiazoles by Ugi-Tetrazole and Huisgen Reaction [PDF]

Organic Letters, 2019
Easy to perform, functional group tolerant, and short syntheses of the privileged scaffold oxadiazole are highly desired. Here, a metal-free protocol for MCR-based synthesis of 2,5-disubstituted 1,3,4-oxadiazoles via a Ugi-tetrazole/Huisgen sequence was developed.
Qian Wang, Kumchok C. Mgimpatsang, Markella Konstantinidou, Svitlana V. Shishkina, Alexander Dömling   +4 more
openaire   +3 more sources

Enantioselective Ugi and Ugi-azide reactions catalyzed by anionic stereogenic-at-cobalt(III) complexes

Nature Communications, 2022
AbstractUgi reactions and related variations are proven to be atom and step-economic strategies for construction of highly valuable peptide-like skeletons and nitrogenous heterocycles. The development of structurally diverse range of novel catalytic systems and the discovery of new approaches to accommodate a broader scope of terminating reagents for ...
Bing-Bing Sun, Kun Liu, Quan Gao, Wei Fang, Shuang Lu, Chun-Ru Wang, Chuan-Zhi Yao, Hai-Qun Cao, Jie Yu   +8 more
openaire   +3 more sources

Predictive Value of Nutrition Indices in Advanced Hepatocellular Carcinoma Patients Treated With Lenvatinib

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT The prognostic nutritional index (PNI) and geriatric nutritional risk index (GNRI) are simple markers that reflect immune and nutritional status. This retrospective study evaluated their prognostic significance in 276 patients with advanced hepatocellular carcinoma (HCC) who received first‐line lenvatinib. PNI and GNRI were calculated based on
Cheng‐Wei Kuo, Wei‐Chen Tai, Yen‐Hao Chen, Ming‐Chao Tsai, Jing‐Houng Wang, Sheng‐Nan Lu, Tsung‐Hui Hu, Chao‐Hung Hung, Chien‐Hung Chen, Yuan‐Hung Kuo   +9 more
wiley   +1 more source

Peptide array functionalization via the Ugi four-component reaction

, 2017
The Ugi four-component reaction was investigated as a tool for the functionalization of peptide arraysviapost-synthetic side-chain modification as well as integration of an Ugi unit into a growing peptide chain.
M. A. R. Meier, Mattes, D. S., Breitling, F., Ridder, B., F. Breitling, D. S. Mattes, Meier, M. A. R., Nesterov-Mueller, A., A. Nesterov-Mueller, B. Ridder   +9 more
core   +1 more source

Exploring a Ugi‐Mediated Polymerization‐Induced Self‐Assembly Approach to Peptoid Particles

Macromolecular Rapid Communications, EarlyView.
Ugi‐mediated polymerization‐induced self‐assembly (U‐PISA) enables the one‐pot synthesis of PEG‐stabilized polypeptoid nanoparticles under mild aqueous conditions. By tuning PEG molar mass and feed composition, tunable spherical and worm‐like nano‐objects are obtained.
Thi Phuong Thu Nguyen, Maria Cristina Molaro, Hao‐Ning Tien, Lei Lei, Pierre Stiernet, Clemence Le Coeur, Federica Sodano, Antoine Debuigne, Benoit Couturaud   +8 more
wiley   +1 more source

Cleavable β-Cyanoethyl Isocyanide in the Ugi Tetrazole Reaction [PDF]

Organic Letters, 2016
β-Cyanoethyl isocyanide is introduced as a cleavable isocyanide in the Ugi tetrazole reaction. Eleven examples are described that exhibit a broad scope and are obtained in good overall yields. The obtained 1H-tetrazole scaffold is an important bioisostere for carboxylic acids, and the method described here is a valuable alternative route to known ...
Kroon, Edwin; Kurpiewska, Katarzyna; Kalinowska-Tluscik, Justyna; Domling, Alexander   +4 more
openaire   +3 more sources

SYNTHESIS OF AZULENE AMIDE DERIVATIVES BY SOLVENT-FREE UGI REACTION [PDF]

, 2014
A simple and eco-friendly synthesis of azulene amide derivatives has achieved via solvent-free Ugi reaction. We found that efficient solvent-free reactions required the formation of a liquid phase throughout the course of the reactions.
熊倉 健太
core