Results 61 to 70 of about 2,155,266 (206)

Enantioselective Ugi and Ugi-azide reactions catalyzed by anionic stereogenic-at-cobalt(III) complexes

Nature Communications, 2022
AbstractUgi reactions and related variations are proven to be atom and step-economic strategies for construction of highly valuable peptide-like skeletons and nitrogenous heterocycles. The development of structurally diverse range of novel catalytic systems and the discovery of new approaches to accommodate a broader scope of terminating reagents for ...
Bing-Bing Sun, Kun Liu, Quan Gao, Wei Fang, Shuang Lu, Chun-Ru Wang, Chuan-Zhi Yao, Hai-Qun Cao, Jie Yu   +8 more
openaire   +3 more sources

Predictive Value of Nutrition Indices in Advanced Hepatocellular Carcinoma Patients Treated With Lenvatinib

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT The prognostic nutritional index (PNI) and geriatric nutritional risk index (GNRI) are simple markers that reflect immune and nutritional status. This retrospective study evaluated their prognostic significance in 276 patients with advanced hepatocellular carcinoma (HCC) who received first‐line lenvatinib. PNI and GNRI were calculated based on
Cheng‐Wei Kuo, Wei‐Chen Tai, Yen‐Hao Chen, Ming‐Chao Tsai, Jing‐Houng Wang, Sheng‐Nan Lu, Tsung‐Hui Hu, Chao‐Hung Hung, Chien‐Hung Chen, Yuan‐Hung Kuo   +9 more
wiley   +1 more source

Molecular Basis for Uracil‐DNA‐Glycosylase to Identify DNA Damage in the Nucleosome

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The DNA base‐excision repair (BER) pathway is initiated by a glycosylase, such as uracil‐DNA‐glycosylase (UDG), which identifies and removes a wrong base incorporated in the DNA sequence. The very early steps in the identification of the DNA damage are crucial to the correct initiation of the repair chain, and become even more complex when ...
Safwen Ghediri, Ralf Blossey, Fabrizio Cleri   +2 more
wiley   +1 more source

Cleavable β-Cyanoethyl Isocyanide in the Ugi Tetrazole Reaction [PDF]

Organic Letters, 2016
β-Cyanoethyl isocyanide is introduced as a cleavable isocyanide in the Ugi tetrazole reaction. Eleven examples are described that exhibit a broad scope and are obtained in good overall yields. The obtained 1H-tetrazole scaffold is an important bioisostere for carboxylic acids, and the method described here is a valuable alternative route to known ...
Kroon, Edwin; Kurpiewska, Katarzyna; Kalinowska-Tluscik, Justyna; Domling, Alexander   +4 more
openaire   +3 more sources

Use of Ugi-three component reaction for the synthesis of poly(α-amino amide)s

, 2019
Multicomponent reactions (MCRs), in which three or more compounds react and form a product containing essentially all atoms of the starting reagents, have been thoroughly exploited in organic synthesis for preparing complex molecules.
Lecomte, Philippe, Stiernet, Pierre, De Winter, Julien, Debuigne, Antoine   +3 more
core   +1 more source

Impact of Upper Gastrointestinal Involvement on Clinical Outcomes in Paediatric Inflammatory Bowel Disease

Acta Paediatrica, EarlyView.
ABSTRACT Aim The aim of this study was to assess the clinical implications of upper gastrointestinal (UGI) involvement in paediatric inflammatory bowel disease (IBD). Methods This retrospective cohort study included children diagnosed with IBD between 2010 and 2023, who underwent a UGI endoscopic evaluation at diagnosis and were followed for at least ...
Ofek Aloni, Adi Anafy, Hadar Moran‐Lev, Achiya Amir, Alma Ziv, Reut Doyev, Tut Galai, Shlomi Cohen, Anat Yerushalmy‐Feler   +8 more
wiley   +1 more source

Direct Preparation of Unsymmetrical Difunctionalized Cyclen Derivatives by an Ugi Multicomponent Reaction

, 2016
The paper describes a new, high hild and efficient synthetic protocol for the preparation of unsymmetrical difunctionalized cyclen and its close derivatives using a modified Ugi reaction (N-split Ugi) is described.
Mauro Formica (1813765), Giovanni Piersanti (1632979), Vieri Fusi (1813759), Giovanni Zappia (2397997), Francesco Remi (2398000), Luca Giorgi (1813747)   +5 more
core   +2 more sources

Million‐Year Scale Hydrothermal and Hydrocarbon Evolution Hosted Within Stratified Thermohydraulic Systems in Sedimented Ultraslow‐Spreading Settings, Svyatogor and Vestnesa Ridges

Geophysical Research Letters, Volume 53, Issue 20, 28 October 2026.
Abstract Hydrothermal systems at ultraslow‐spreading ridges are poorly understood, especially where thick sediments overlay detachment faults. The International Ocean Discovery Program Expedition 403 obtained the longest sediment record in Atlantic‐Arctic ultraslow‐spreading systems, reaching ∼628 m below the seafloor.
Y. Sakai, Y. Fukamatsu, V. J. Clementi, Y. Rosenthal, J. Gruetzner, S. Bünz, A. Plaza‐Faverola, K. St. John, R. G. Lucchi, T. A. Ronge, O. Libman‐Roshal, L. Monito, Y. Liu, M. Iizuka, L. Duxbury, L. Haygood, O. Tadai, G.‐I. Uramoto, W. Lin, Expedition 403 Shipboard Scientists   +19 more
wiley   +1 more source

Artificial Macrocycles by Ugi Reaction and Passerini Ring Closure [PDF]

The Journal of Organic Chemistry, 2016
Artificial macrocycles can be convergently synthesized by a sequence of an Ugi multicomponent reaction (MCR) followed by an intramolecular Passerini MCR used to close the macrocycle. Significantly, in this work, the first intramolecular macrocyclization through a Passerini reaction is described. We describe 21 macrocycles of a size of 15-20.
Abdelraheem, Eman M. M.; Kurpiewska, Katarzyna; Kalinowska-Tluscik, Justyna; Domling, Alexander   +4 more
openaire   +4 more sources

In Silico and in Vitro Studies of Fluorinated Chroman-2-Carboxilic Acid Derivatives as an Anti-tubercular Agent

Folia Medica, 2018
Background: Despite the use of traditional method, Ugi reaction currently is a well-established multicomponent reaction. Chromane motif itself possesses a variety of biological functions.
Kapadiya Khushal M., Jadeja Yashwantsinh S., Banik Avishek, Khunt Ranjan C.   +3 more
doaj   +1 more source