Results 61 to 70 of about 4,769 (209)

Cage-like microstructures via sequential Ugi reactions in aqueous emulsions

Beilstein Journal of Organic Chemistry
Cage-like microstructures were obtained in two steps by sequential Ugi reactions. At the first stage, submicron colloidal particles based on carboxymethylcellulose and chitosan with a domain structure were obtained in an aqueous suspension. In the second
Rita S. Alqubelat, Yaroslava A. Menzorova, Maxim A. Mironov   +2 more
doaj   +1 more source

Smiles/Pudovik/Phospha–Brook Cascades from Passerini–Smiles Adducts

ChemistryEurope, Volume 4, Issue 6, June 2026.
The Passerini–Smiles reaction of aliphatic ketophosphonates affords starting materials for complex cascades triggered by a first Smiles rearrangement. The cascade showcases the power of phosphorous based transformations. Here the reversibility of the Pudovik reaction allows a further Truce–Smiles reaction enol before final Pudovik/Phosph–Brook sequence.
Cristina Cheibas, Nicolas Casaretto, Laurent El Kaim   +2 more
wiley   +1 more source

Enantioselective Ugi and Ugi-azide reactions catalyzed by anionic stereogenic-at-cobalt(III) complexes

Nature Communications, 2022
AbstractUgi reactions and related variations are proven to be atom and step-economic strategies for construction of highly valuable peptide-like skeletons and nitrogenous heterocycles. The development of structurally diverse range of novel catalytic systems and the discovery of new approaches to accommodate a broader scope of terminating reagents for ...
Bing-Bing Sun, Kun Liu, Quan Gao, Wei Fang, Shuang Lu, Chun-Ru Wang, Chuan-Zhi Yao, Hai-Qun Cao, Jie Yu   +8 more
openaire   +3 more sources

Peptide array functionalization via the Ugi four-component reaction

, 2017
The Ugi four-component reaction was investigated as a tool for the functionalization of peptide arraysviapost-synthetic side-chain modification as well as integration of an Ugi unit into a growing peptide chain.
M. A. R. Meier, Mattes, D. S., Breitling, F., Ridder, B., F. Breitling, D. S. Mattes, Meier, M. A. R., Nesterov-Mueller, A., A. Nesterov-Mueller, B. Ridder   +9 more
core   +1 more source

Advances of Ugi reaction in natural product synthesis

Green Synthesis and Catalysis
The Ugi multicomponent reaction represents a highly efficient synthetic transformation, wherein all four reactants (isocyanides, amine, aldehyde or ketone and a nucleophile) are combined in one pot under mild conditions. This reaction exhibits remarkable
Wen Zhang, Pei Tang, Mohamed Aamer Abubaker, Guo-Hua Hu, Fen-Er Chen   +4 more
doaj   +1 more source

Artificial Macrocycles by Ugi Reaction and Passerini Ring Closure. [PDF]

J Org Chem, 2016
Artificial macrocycles can be convergently synthesized by a sequence of an Ugi multicomponent reaction (MCR) followed by an intramolecular Passerini MCR used to close the macrocycle. Significantly, in this work, the first intramolecular macrocyclization through a Passerini reaction is described. We describe 21 macrocycles of a size of 15-20.
Abdelraheem EM, Kurpiewska K, Kalinowska-Tłuścik J, Dömling A.   +3 more
europepmc   +6 more sources

Chloroplast‐ and mitochondrion‐specific random C‐to‐T mutagenesis for forward genetics of organelle genomes

The Plant Journal, Volume 126, Issue 5, June 2026.
Significance Statement This study provides a chloroplast‐ and mitochondrion‐specific random mutagenesis tool specialized for C‐to‐T substitutions, enabling organelle genome‐focused forward genetic analysis. By utilizing this tool, we can screen for organelle genome‐associated traits and isolate novel mutations that are not only of physiological ...
Nanami Kosaka, Yoshiki Harada, Issei Nakazato, Miki Okuno, Takehiko Itoh, Nobuhiro Tsutsumi, Shin‐ichi Arimura   +6 more
wiley   +1 more source

Protein-Templated Hit Identification through an Ugi Four-Component Reaction. [PDF]

, 2020
Kinetic target-guided synthesis represents an efficient hit-identification strategy, in which the protein assembles its own inhibitors from a pool of complementary building blocks via an irreversible reaction. Herein, we pioneered an in situ Ugi reaction
Jumde, Varsha R, Blankenfeldt, Wulf, Müller, Rolf, Mancini, Federica, Alaa Alhayek, Unver, M Yagiz, Elgaher, Walid A M, Witte, Martin D, Varsha R. Jumde, Rolf Müller, Hirsch, Anna K.H., Witte, Martin D., Köck, Matthias, Federica Mancini, M. Yagiz Unver, Unver, M. Yagiz, Jennifer Herrmann, Wulf Blankenfeldt, Peer Lukat, Matthias Köck, Hirsch, Anna K H, Martin D. Witte, Anna K. H. Hirsch, Alhayek, Alaa, Witte, Martin D.; id_orcid, Lukat, Peer, Herrmann, Jennifer, Walid A. M. Elgaher, Jumde, Varsha R., Elgaher, Walid A.M.   +29 more
core   +1 more source

In Silico and in Vitro Studies of Fluorinated Chroman-2-Carboxilic Acid Derivatives as an Anti-tubercular Agent

Folia Medica, 2018
Background: Despite the use of traditional method, Ugi reaction currently is a well-established multicomponent reaction. Chromane motif itself possesses a variety of biological functions.
Kapadiya Khushal M., Jadeja Yashwantsinh S., Banik Avishek, Khunt Ranjan C.   +3 more
doaj   +1 more source

Synthesis, Characterization and Chemistry of Tetrakis(Propargylisocyanide) Copper(I) Complex

Molbank, 2023
The kinetically unstable propargylisocyanide was reacted with the tetrakis(acetonitrile) copper(I) hexafluorophosphate and the formed complex was then involved in a copper-catalyzed alkyne-azide cycloaddition reaction (CuAAC). After the decomplexation of
Alexandre Quelhas, Thierry Roisnel, Jean-Claude Guillemin, Yann Trolez   +3 more
doaj   +1 more source