Results 91 to 100 of about 4,769 (209)

Convergent synthesis of 13N-labelled Peptidic structures using aqueous [13N]NH3

EJNMMI Radiopharmacy and Chemistry, 2017
Background Nitrogen-13 has a 10-min half-life which places time constraints on the complexity of viable synthetic methods for its incorporation into PET imaging agents.
Julia E. Blower, Samuel F. Cousin, Antony D. Gee   +2 more
doaj   +1 more source

Synthesis of Polyheterocyclic Pyrrolo[3,4-b]pyridin-5-ones via a One-Pot (Ugi-3CR/aza Diels-Alder/N-acylation/aromatization/SN2) Process. A Suitable Alternative towards Novel Aza-Analogues of Falipamil

Molecules, 2018
We describe the one-pot synthesis of twenty polyheterocyclic pyrrolo[3,4-b]pyridin-5-ones via a cascade process (Ugi-3CR/aza Diels-Alder/N-acylation/aromatization) in 20 to 95% overall yields, as well as four pharmacologically promising analogues via an ...
Angel Zamudio-Medina, Ailyn N. García-González, Genesis K. Herrera-Carrillo, Daniel Zárate-Zárate, Adriana Benavides-Macías, Joaquín Tamariz, Ilich A. Ibarra, Alejandro Islas-Jácome, Eduardo González-Zamora   +8 more
doaj   +1 more source

SYNTHESIS OF AZULENE AMIDE DERIVATIVES BY SOLVENT-FREE UGI REACTION

, 2014
A simple and eco-friendly synthesis of azulene amide derivatives has achieved via solvent-free Ugi reaction. We found that efficient solvent-free reactions required the formation of a liquid phase throughout the course of the reactions.
熊倉 健太
core  

Ugi Four-Center Three-Component Reaction as a Direct Approach to Racetams [PDF]

, 2017
We report the synthesis of racetams, a diverse class of small molecule drugs, by means of the Ugi four-center three-component reaction (U4C-3CR). For the first time, γ-aminobutyric acid is employed as bifunctional input in the Ugi reaction. This protocol
Schuckman, Peter, Ruijter, Eelco; id_orcid, van Riempst, Lola Schaepkens, Ruijter, Eelco, Orru, Romano V. A.; id_orcid, Cioc, Razvan C., Orru, Romano V. A.   +6 more
core   +1 more source

Ugi bisamides based on pyrrolyl-β-chlorovinylaldehyde and their unusual transformations

Beilstein Journal of Organic Chemistry
By one-pot four- and three-component Ugi reactions involving convertible isocyanides and unexplored pyrrole-containing β-chlorovinylaldehyde, a small library of 20 bisamides with unusual behavior in post-Ugi transformations was prepared and characterized.
Alexander V. Tsygankov, Vladyslav O. Vereshchak, Tetiana O. Savluk, Serhiy M. Desenko, Valeriia V. Ananieva, Oleksandr V. Buravov, Yana I. Sakhno, Svitlana V. Shishkina, Valentyn A. Chebanov   +8 more
doaj   +1 more source

Combining the Ugi-azide multicomponent reaction and rhodium(III)-catalyzed annulation for the synthesis of tetrazole-isoquinolone/pyridone hybrids

Beilstein Journal of Organic Chemistry, 2019
An efficient sequence based on the Ugi-azide reaction and rhodium(III)-catalyzed intermolecular annulation has been established for the preparation of tetrazole-isoquinolone/pyridone hybrids.
Gerardo M. Ojeda, Prabhat Ranjan, Pavel Fedoseev, Lisandra Amable, Upendra K. Sharma, Daniel G. Rivera, Erik V. Van der Eycken   +6 more
doaj   +1 more source

Ethyl({[acryloyl(furan-2-ylmethyl)amino]acetyl}amino)acetate

Molbank, 2017
Ethyl({[acryloyl(furan-2-ylmethyl)amino]acetyl}amino)acetate was synthesized via Ugi four component (4C) reaction at ambient temperature. The protocol employs a reaction between formaldehyde, furfurylamine, acrylic acid, and ethyl 2-isocyanoacetate.
Shimoga D. Ganesh, Nabanita Saha, Ronald N. Zuckermann, Petr Sáha   +3 more
doaj   +1 more source

Rh(III)-Catalyzed C-2 Alkylation of Indoles followed by a Post-Synthetic Modification via the Ugi Reaction. [PDF]

ChemistryOpen, 2023
Januário MAP, de Souza DP, Zukerman-Schpector J, Corrêa AG.   +3 more
europepmc   +1 more source

Synthesis of seven-membered nitrogen heterocycles through the Ugi multicomponent reaction

, 2017
This paper reviews all the syntheses of 7-membered nitrogen heterocycles that are based on the Ugi multicomponent reaction. Different systems may be obtained in a diversity-oriented manner employing three general strategies: i) intramolecular Ugi ...
LAMBRUSCHINI, CHIARA, BANFI, LUCA, RIVA, RENATA, BASSO, ANDREA, MONI, LISA   +4 more
core  

Synthesis of Novel Lipophilic Polyamines via Ugi Reaction and Evaluation of Their Anticancer Activity. [PDF]

Molecules, 2022
Nichugovskiy A, Maksimova V, Trapeznikova E, Eshtukova-Shcheglova E, Ivanov I, Yakubovskaya M, Kirsanov K, Cheshkov D, Tron GC, Maslov M.   +9 more
europepmc   +1 more source