Results 91 to 100 of about 2,043,921 (203)

Ugi Four-Center Three-Component Reaction as a Direct Approach to Racetams [PDF]

, 2017
We report the synthesis of racetams, a diverse class of small molecule drugs, by means of the Ugi four-center three-component reaction (U4C-3CR). For the first time, γ-aminobutyric acid is employed as bifunctional input in the Ugi reaction. This protocol
Schuckman, Peter, Ruijter, Eelco; id_orcid, van Riempst, Lola Schaepkens, Ruijter, Eelco, Orru, Romano V. A.; id_orcid, Cioc, Razvan C., Orru, Romano V. A.   +6 more
core   +1 more source

Organocatalytic Double Ugi Reaction with Statistical Amplification of Product Enantiopurity: A Linker Cleavage Approach To Access Highly Enantiopure Ugi Products

, 2019
Here we report an organocatalytic double Ugi reaction combining the enantioselective process and ee enhancement in a single operation to afford the chiral Ugi products with very high ee values.
Mei-Xiang Wang, Shuo Tong (2796949), Jieping Zhu, Jieping Zhu (1450051), Qi-Yun Feng, Qi-Yun Feng (8194815), Mei-Xiang Wang (536990), Shuo Tong   +7 more
core   +1 more source

A Tandem Cyclization-Ugi Sequence of Reactions for the Synthesis of 1,4-Benzoxazine-3-carboxamide Derivatives

Heteroatom Chemistry
Benzo[b][1,4]oxazines constitute an important scaffold in synthetic organic chemistry in terms of having special applications in drug discovery and bioactive compounds. Thus, finding new methods for their synthesis is of high importance.
Ali Sharifi, Marzieh Sharifi, M. Saeed Abaee, Mojtaba Mirzaei   +3 more
doaj   +1 more source

Synthesis of 4-azasteroids by an intramolecular Ugi reaction

Steroids, 2008
In this paper we report the use of an intramolecular Ugi reaction to synthesize new 4-azacholestanes diversely substituted both at N-4 and C-5. Both the scope and the stereochemical outcome of this approach were studied by varying the nature of the components necessary for this multicomponent reaction.
Alonso, Fernando, Acebedo, Sofía Lorena, Bruttomesso, Andrea, Ramirez, Javier Alberto   +3 more
openaire   +3 more sources

Convergent synthesis of 13N-labelled Peptidic structures using aqueous [13N]NH3

EJNMMI Radiopharmacy and Chemistry, 2017
Background Nitrogen-13 has a 10-min half-life which places time constraints on the complexity of viable synthetic methods for its incorporation into PET imaging agents.
Julia E. Blower, Samuel F. Cousin, Antony D. Gee   +2 more
doaj   +1 more source

Rh(III)-Catalyzed C-2 Alkylation of Indoles followed by a Post-Synthetic Modification via the Ugi Reaction. [PDF]

ChemistryOpen, 2023
Januário MAP, de Souza DP, Zukerman-Schpector J, Corrêa AG.   +3 more
europepmc   +1 more source

Ugi bisamides based on pyrrolyl-β-chlorovinylaldehyde and their unusual transformations

Beilstein Journal of Organic Chemistry
By one-pot four- and three-component Ugi reactions involving convertible isocyanides and unexplored pyrrole-containing β-chlorovinylaldehyde, a small library of 20 bisamides with unusual behavior in post-Ugi transformations was prepared and characterized.
Alexander V. Tsygankov, Vladyslav O. Vereshchak, Tetiana O. Savluk, Serhiy M. Desenko, Valeriia V. Ananieva, Oleksandr V. Buravov, Yana I. Sakhno, Svitlana V. Shishkina, Valentyn A. Chebanov   +8 more
doaj   +1 more source

Doebner-type pyrazolopyridine carboxylic acids in an Ugi four-component reaction

Beilstein Journal of Organic Chemistry, 2019
Substituted 1H-pyrazolo[3,4-b]pyridine-4- and 1H-pyrazolo[3,4-b]pyridine-6-carboxamides have been synthetized through a Doebner–Ugi multicomponent reaction sequence in a convergent and versatile manner using diversity generation strategies: combination ...
Maryna V. Murlykina, Oleksandr V. Kolomiets, Maryna M. Kornet, Yana I. Sakhno, Sergey M. Desenko, Victoriya V. Dyakonenko, Svetlana V. Shishkina, Oleksandr A. Brazhko, Vladimir I. Musatov, Alexander V. Tsygankov, Erik V. Van der Eycken, Valentyn A. Chebanov   +11 more
doaj   +1 more source

Synthesis of Polyheterocyclic Pyrrolo[3,4-b]pyridin-5-ones via a One-Pot (Ugi-3CR/aza Diels-Alder/N-acylation/aromatization/SN2) Process. A Suitable Alternative towards Novel Aza-Analogues of Falipamil

Molecules, 2018
We describe the one-pot synthesis of twenty polyheterocyclic pyrrolo[3,4-b]pyridin-5-ones via a cascade process (Ugi-3CR/aza Diels-Alder/N-acylation/aromatization) in 20 to 95% overall yields, as well as four pharmacologically promising analogues via an ...
Angel Zamudio-Medina, Ailyn N. García-González, Genesis K. Herrera-Carrillo, Daniel Zárate-Zárate, Adriana Benavides-Macías, Joaquín Tamariz, Ilich A. Ibarra, Alejandro Islas-Jácome, Eduardo González-Zamora   +8 more
doaj   +1 more source

Combining the Ugi-azide multicomponent reaction and rhodium(III)-catalyzed annulation for the synthesis of tetrazole-isoquinolone/pyridone hybrids

Beilstein Journal of Organic Chemistry, 2019
An efficient sequence based on the Ugi-azide reaction and rhodium(III)-catalyzed intermolecular annulation has been established for the preparation of tetrazole-isoquinolone/pyridone hybrids.
Gerardo M. Ojeda, Prabhat Ranjan, Pavel Fedoseev, Lisandra Amable, Upendra K. Sharma, Daniel G. Rivera, Erik V. Van der Eycken   +6 more
doaj   +1 more source