Results 111 to 120 of about 4,769 (209)

The multicomponent approach to N-methyl peptides: total synthesis of antibacterial (–)-viridic acid and analogues

Beilstein Journal of Organic Chemistry, 2012
Two syntheses of natural viridic acid, an unusual triply N-methylated peptide with two anthranilate units, are presented. The first one is based on peptide-coupling strategies and affords the optically active natural product in 20% overall yield over six
Ricardo A. W. Neves Filho, Sebastian Stark, Bernhard Westermann, Ludger A. Wessjohann   +3 more
doaj   +1 more source

Effective microwave-assisted approach to 1,2,3-triazolobenzodiazepinones via tandem Ugi reaction/catalyst-free intramolecular azide-alkyne cycloaddition. [PDF]

Beilstein J Org Chem, 2021
Mazur MO, Zhelavskyi OS, Zviagin EM, Shishkina SV, Musatov VI, Kolosov MA, Shvets EH, Andryushchenko AY, Chebanov VA.   +8 more
europepmc   +1 more source

Optimization of a Novel Oxy-Michael Ugi-Smiles Reaction

, 2017
Synthesis of complex, biologically active molecules is critical for the discovery and development of potential pharmaceutical agents. Multicomponent coupling reactions (MCRs) are “one-pot reactions” that combine three or more compounds simultaneously to ...
Ayres, Robert
core  

Ugi reaction in the synthesis of Janus dendrimers as nanocarriers of chlorambucil and ibuprofen

Results in Chemistry
The synthesis and characterization of Janus dendrimers conjugated with two drugs: chlorambucil and ibuprofen are reported. The dendrons by the Ugi reaction were obtained.
Israel Barajas-Mendoza, Teresa Ramírez-Ápan, Marcos Martínez-García   +2 more
doaj   +1 more source

Tritylamine as an Ammonia Surrogate in the Ugi Reaction Provides Access to Unprecedented 5-Sulfamido Oxazoles Using Burgess-type Reagents. [PDF]

Org Lett, 2021
Bhela IP, Serafini M, Del Grosso E, Tron GC, Pirali T.   +4 more
europepmc   +1 more source

Diastereoselective Ugi Reaction Without Chiral Amines: The Synthesis of Chiral Pyrroloketopiperazines

, 2007
The three-component Ugi reaction with chiral 2-(2-formyl-1H-pyrrol-1-yl)acetic acids prepared from natural l-aminoacids was investigated. The reaction opens a new route to chiral substituted pyrroloketopiperazines.
Reznichenko, Alexander L.; id_orcid, Balenkova, Elizabeth S., Valentine G. Nenajdenko, Elizabeth S. Balenkova, Alexander L. Reznichenko, Nenajdenko, Valentine G.   +5 more
core   +1 more source

Silver(I) triflate-catalyzed post-Ugi synthesis of pyrazolodiazepines

Beilstein Journal of Organic Chemistry
A silver(I) triflate-catalyzed post-Ugi assembly of novel pyrazolo[1,5-a][1,4]diazepine scaffolds is reported offering high yields (up to 98%) under mild conditions.
Muhammad Hasan, Anatoly A. Peshkov, Syed Anis Ali Shah, Andrey Belyaev, Chang-Keun Lim, Shunyi Wang, Vsevolod A. Peshkov   +6 more
doaj   +1 more source

Organocatalytic Double Ugi Reaction with Statistical Amplification of Product Enantiopurity: A Linker Cleavage Approach To Access Highly Enantiopure Ugi Products

Here we report an organocatalytic double Ugi reaction combining the enantioselective process and ee enhancement in a single operation to afford the chiral Ugi products with very high ee values.
Tong, Shuo, Wang, Mei-Xiang, Zhu, Jieping, Feng, Qi-Yun   +3 more
core   +1 more source

One-pot synthesis of oxoisoindoline-1,2,3-triazole hybrid by a Ugi–click reaction

, 2016
1,2,3-Triazole-3-oxoisoindoline-1-carboxamide system was successfully synthesized by using a combination of Ugi and click reactions. This two-step, one-pot synthesis was started by the reaction of 2-formyl benzoic acid, propargyl amine, and cyclohexyl ...
Loghman Firoozpour (657961), Afsaneh Zonouzi (1960039), Mohammad Mahdavi (526321), Alireza Foroumadi (526325), Setareh Moghimi (769980), Sara Akrami (3071019), Fereshteh Goli-Garmroodi (3071022)   +6 more
core   +1 more source

Ugi Multicomponent Reaction

Organic Syntheses, 2017
Dömling, Alexander, Boltjes, André, Liu, Haixia, Cao, Haiping, Baker-Tripp, Emma L   +4 more
openaire   +1 more source