Results 1 to 10 of about 22,422 (224)
2‐Nitrobenzyl Isocyanide as a Universal Convertible Isocyanide [PDF]
Asian Journal of Organic Chemistry, 2017 Abstract2‐Nitrobenzyl isocyanide is reported as a universal convertible isocyanide with extensive applicability in both Ugi four‐component reaction (Ugi‐4CR) and Ugi‐tetrazole reaction. The cleavage of this isocyanide from 17 examples in both acidic and basic conditions is presented.
Ajay L Chandgude +2 more
exaly +6 more sources
Efficient Isocyanide-less Isocyanide-Based Multicomponent Reactions [PDF]
Organic Letters, 2015 Isocyanides are the "Jekyll and Hyde" of organic chemistry allowing for extremely interesting transformations that are not only extremely odorous but also noxious. Therefore, an isocyanide-less isocyanide-based multicomponent reaction (IMCR) has been developed, and this protocol is expected to replace many of the old procedures in the future not only ...
Neochoritis +4 more
openaire +5 more sources
The isocyanide SN2 reaction [PDF]
Nature Communications, 2023 Abstract The S N 2 nucleophilic substitution reaction is a vital organic transformation used for drug and natural product synthesis. Nucleophiles like cyanide, oxygen, nitrogen, sulfur, or phosphorous replace halogens or sulfonyl esters, forming new bonds.
Pravin Patil +3 more
openaire +5 more sources
Synthesis and structure of a tetrahedral homoleptic CuI complex with xylyl isocyanide [PDF]
Acta Crystallographica Section E: Crystallographic CommunicationsTreatment of the CuI precursor [Cu(NCMe)4]PF6 with excess (10 equivalents) of relatively bulky xylyl isocyanide formed a tetra(isocyanide) complex, namely, tetrakis(2,6-dimethylphenylisocyanide)copper(I) hexafluorophosphate, [Cu(C9H9N)4]PF6 or [Cu(CNXyl ...
A. M. Buddhika Chandima +2 more
doaj +2 more sources
Investigating the bioorthogonality of isocyanides.
Chem Commun (Camb)Isocyanides have been explored as bioorthogonal triggers for uncaging reactions. However, our findings show they can covalently label proteins, indicating they may not be fully bioorthogonal in biological systems.
Nakao R +7 more
europepmc +5 more sources
Green Chemistry, 2020 Isocyanides are important chemicals, with limited availability, thus reducing their general use. Our highly improved isocyanide synthesis performed on mole to μ-mole scale, individually or in a 96-well parallel fashion enables unprecedented exploration of novel chemistries.
Pravin Patil +2 more
openaire +4 more sources
(tert-Butyl isocyanide-κC)trichloridogallium(III)
IUCrData, 2016 The crystal structure of (tert-butyl isocyanide-κC)trichloridogallium(III), [GaCl3(C5H9N)], features the first reported isocyanide–gallium trihalide complex. The Ga—C—N—C fragment is essentially linear.
Jeremy L. Bourque +2 more
doaj +2 more sources
Tris(tert-butyl isocyanide-κC)carbonylnickel(0)
Acta Crystallographica Section E, 2008 The title compound, [Ni(C5H9N)3(CO)], was prepared from Ni(CO)4 and a tenfold excess of tert-butyl isocyanide. It crystallizes with two symmetry-independent molecules per asymmetric unit.
Wolfgang Imhof +2 more
doaj +2 more sources
Urea Synthesis from Isocyanides and O-Benzoyl Hydroxylamines Catalyzed by a Copper Salt
Molecules, 2022 In the presence of CuOAc, a series of unsymmetric ureas can be generated in moderate to good yields under mild reaction conditions (10 mol% of CuOAc, 2 equiv t-BuONa or PhONa, 30 °C), using aryl isocyanides and O-benzoyl hydroxylamines as the readily ...
Ning Yu +5 more
doaj +1 more source
Medicinal Chemistry of Isocyanides [PDF]
Chemical Reviews, 2021 In eons of evolution, isocyanides carved out a niche in the ecological systems probably thanks to their metal coordinating properties. In 1859 the first isocyanide was synthesized by humans and in 1950 the first natural isocyanide was discovered. Now, at the beginning of XXI century, hundreds of isocyanides have been isolated both in prokaryotes and ...
Alberto Massarotti +4 more
openaire +4 more sources