Results 1 to 10 of about 22,465 (222)
2‐Nitrobenzyl Isocyanide as a Universal Convertible Isocyanide [PDF]
Asian Journal of Organic Chemistry, 2017 Abstract2‐Nitrobenzyl isocyanide is reported as a universal convertible isocyanide with extensive applicability in both Ugi four‐component reaction (Ugi‐4CR) and Ugi‐tetrazole reaction. The cleavage of this isocyanide from 17 examples in both acidic and basic conditions is presented.
Ajay L Chandgude +2 more
exaly +7 more sources
The isocyanide SN2 reaction [PDF]
Nature Communications, 2023 Abstract The S N 2 nucleophilic substitution reaction is a vital organic transformation used for drug and natural product synthesis. Nucleophiles like cyanide, oxygen, nitrogen, sulfur, or phosphorous replace halogens or sulfonyl esters, forming new bonds.
Pravin Patil +3 more
openaire +6 more sources
Synthesis and structure of a tetrahedral homoleptic CuI complex with xylyl isocyanide [PDF]
Acta Crystallographica Section E: Crystallographic CommunicationsTreatment of the CuI precursor [Cu(NCMe)4]PF6 with excess (10 equivalents) of relatively bulky xylyl isocyanide formed a tetra(isocyanide) complex, namely, tetrakis(2,6-dimethylphenylisocyanide)copper(I) hexafluorophosphate, [Cu(C9H9N)4]PF6 or [Cu(CNXyl ...
A. M. Buddhika Chandima +2 more
doaj +2 more sources
Investigating the bioorthogonality of isocyanides.
Chem Commun (Camb)Isocyanides have been explored as bioorthogonal triggers for uncaging reactions. However, our findings show they can covalently label proteins, indicating they may not be fully bioorthogonal in biological systems.
Nakao R +7 more
europepmc +5 more sources
Synthesis of (macro)heterocycles by consecutive/repetitive isocyanide-based multicomponent reactions
Beilstein Journal of Organic Chemistry, 2019 Isocyanide-based multicomponent reactions are a versatile tool in the synthesis of heterocycles. This review describes recently developed approaches based on the combination of consecutive or repetitive isocyanide-based multicomponent reactions for the ...
CARLOS Kleber Zago de Andrade +1 more
exaly +2 more sources
Urea Synthesis from Isocyanides and O-Benzoyl Hydroxylamines Catalyzed by a Copper Salt
Molecules, 2022 In the presence of CuOAc, a series of unsymmetric ureas can be generated in moderate to good yields under mild reaction conditions (10 mol% of CuOAc, 2 equiv t-BuONa or PhONa, 30 °C), using aryl isocyanides and O-benzoyl hydroxylamines as the readily ...
Ning Yu +5 more
doaj +1 more source
Medicinal Chemistry of Isocyanides [PDF]
Chemical Reviews, 2021 In eons of evolution, isocyanides carved out a niche in the ecological systems probably thanks to their metal coordinating properties. In 1859 the first isocyanide was synthesized by humans and in 1950 the first natural isocyanide was discovered. Now, at the beginning of XXI century, hundreds of isocyanides have been isolated both in prokaryotes and ...
Alberto Massarotti +4 more
openaire +4 more sources
Antibiotics, 2023 Multicomponent reactions (MCR) have been used to synthesize a wide range of analogs from several classes of heterocyclic compounds, with multifaceted medicinal uses. The synthesis of highly functionalized molecules in a single pot is a unique property of
Sameer Quazi +3 more
doaj +1 more source
Acta Crystallographica Section E: Crystallographic Communications, 2022 The reaction of the [K(18-crown-6)(thf)2]1+ (thf is tetrahydrofuran) salt of bis(anthracene)ferrate(−1), or [Fe(C14H10)2]−, with 2,6-dimethylphenyl isocyanide (CNXyl) in thf resulted in the formation of two new iron isocyanide complexes, namely, [(1,2,3 ...
William W. Brennessel, John E. Ellis
doaj +1 more source
The mode of action of isocyanide in three aquatic organisms, Balanus amphitrite, Bugula neritina and Danio rerio. [PDF]
PLoS ONE, 2012 Isocyanide is a potential antifouling compound in marine environments. In this study, we investigated its mode of action in three aquatic organisms. Two of them, the bryozoan Bugula neritina and the barnacle Balanus amphitrite, are major marine fouling ...
Yi-Fan Zhang +4 more
doaj +1 more source