Artificial Macrocycles by Ugi Reaction and Passerini Ring Closure [PDF]
The Journal of Organic Chemistry, 2016 Artificial macrocycles can be convergently synthesized by a sequence of an Ugi multicomponent reaction (MCR) followed by an intramolecular Passerini MCR used to close the macrocycle. Significantly, in this work, the first intramolecular macrocyclization through a Passerini reaction is described. We describe 21 macrocycles of a size of 15-20.
Abdelraheem +4 more
core +6 more sources
An efficient Passerini tetrazole reaction (PT-3CR) [PDF]
Green Chemistry, 2016 A sonication accelerated, catalyst free, simple, high yielding and efficient method for the Passerini-type three-component reaction (PT-3CR) has been developed.
Chandgude, Ajay L.; Domling, Alexander
openaire +5 more sources
Unconventional Passerini Reaction toward α-Aminoxy-amides [PDF]
Organic Letters, 2016 The Passerini multicomponent reaction (P-3CR) toward the one-step synthesis of α-aminoxy-amide, by employing for the first time a N-hydroxamic acid component, has been reported. The sonication-accelerated, catalyst-free, simple, fast, and highly efficient Passerini reaction is used for the synthesis of diverse α-aminoxy-amides.
Chandgude, Ajay L.; Domling, Alexander
openaire +4 more sources
Innovations and Inventions: Why Was the Ugi Reaction Discovered Only 37 Years after the Passerini Reaction? [PDF]
J Org Chem, 2023 This year represents the 100th anniversary of the discovery of the Passerini three-component reaction. The related Ugi four-compound reaction was discovered 37 years after the Passerini reaction.
Dömling A.
europepmc +2 more sources
Hexafluoroisopropanol as the Acid Component in the Passerini Reaction: One-Pot Access to β-Amino Alcohols. [PDF]
Org Lett, 2018 A new Passerini-type reaction in which hexafluoroisopropanol functions as the acid component is reported. The reaction tolerates a broad range of isocyanides and aldehydes, and the formed imidates can be reduced toward β-amino alcohols under mild and ...
Saya JM +6 more
europepmc +2 more sources
Kinetics and Mechanism of the Enantioselective Passerini Multicomponent Reaction Catalyzed by Chiral Ionic Liquids [PDF]
ACS OmegaJuliana Santos +8 more
doaj +2 more sources
SynOpen, 2021 An efficient and straightforward approach has been established for the preparation of a new class of depsipeptide structures via isocyanide-based consecutive Bargellini–Passerini multicomponent reactions.
Hassan Farhid +3 more
doaj +1 more source
Streamlined One-Pot Synthesis of Fused Pyrroles: A Three-Component Approach. [PDF]
ChemistryOpenNew modified pyrrole derivatives, namely tetrahydroindol‐4‐ones and pyrrolo[2,3‐d]pyrimidines, functionalized at position 3, were synthesized through a one‐pot multicomponent condensation. Stabilized dimedone enaminones derived from α‐amino acids and their esters (or 6‐amino‐1,3‐dimethyluracil), arylglyoxals, and methylene‐active compounds ...
Marchenko KI +5 more
europepmc +2 more sources
Keto-Enol Tautomerism in Passerini and Ugi Adducts
Molecules, 2021 The use of arylglyoxal as starting material in Passerini and Ugi reactions affords β-ketoamides. This has allowed to study keto-enol tautomerism in these systems and assess the way in which the presence of acyloxy or aminoacyl groups bound to the C2 ...
Pablo Pertejo +8 more
doaj +1 more source
Prevalence and Molecular Profiling of Merkel Cell Polyomavirus in Patients With Monkeypox Virus Infection. [PDF]
J Med VirolABSTRACT Mpox, caused by Monkeypox virus (MPXV), is associated with mucosal involvement and immune modulation that may influence viral coinfections. Merkel Cell Polyomavirus (MCPyV), a ubiquitous virus capable of lifelong persistence, was investigated in 66 Mpox patients enrolled at Lazzaro Spallanzani National Institute for Infectious Diseases (Rome ...
Passerini S +8 more
europepmc +2 more sources