Results 31 to 40 of about 23,776 (268)
Angewandte Chemie, EarlyView.The impact of C‐3 fluorination on the synthesis and conformation of alginate oligosaccharides is investigated. A C‐3‐fluoro mannuronic acid building block is generated and shown to react with high β‐selectivity. Automated glycan assembly enables access to uniquely fluorinated mannuronic acid alginates where deoxyfluorination is shown not to perturb the
Sean T. Evans +10 more
wiley +2 more sources
Nickel-Catalyzed Kumada Cross-Coupling Reactions of Benzylic Sulfonamides
Molecules, 2021 Herein, we report a Kumada cross-coupling reaction of benzylic sulfonamides. The scope of the transformation includes acyclic and cyclic sulfonamide precursors that cleanly produce highly substituted acyclic fragments.
Kirsten A. Hewitt +3 more
doaj +1 more source
Diastereoselective Addition of Diazomethane to Zaluzanin A [PDF]
Natural Product Communications, 2014 The diastereoselectivity of diazomethane addition to the conjugated double bond of α,β-unsaturated sesquiterpene lactones was explored using zaluzanin A (1) as a model. Thus, the absolute configuration of 1 was assured by X-ray diffraction analysis including evaluation of Flack and Hooft parameters, and by vibrational circular ...
Adriana, Ortiz-León +6 more
openaire +2 more sources
Catalytic Enantioselective Intramolecular Aza‐Michael Addition to α,β‐Unsaturated Esters
Angewandte Chemie, EarlyView.A general method for accessing enantioenriched saturated N‐heterocycles via a catalytic enantioselective intramolecular aza‐Michael reaction to α,β‐unsaturated esters is described. A superbasic bifunctional iminophosphorane (BIMP) catalyst was key to enabling reactivity of the high pKa sulfonamide pronucleophile, whilst delivering good to excellent ...
Evan G. W. Rutter +5 more
wiley +2 more sources
Beilstein Journal of Organic Chemistry, 2016 An efficient diastereoselective approach for the synthesis of functionalized 3,4-dihydro-2H-pyran-4-carboxamides with variable frame was developed based on the reaction of available 4-oxoalkane-1,1,2,2-tetracarbonitriles (adducts of TCNE and ketones ...
Mikhail Yu. Ievlev +5 more
doaj +1 more source
Molbank, 2023 An unexpected diastereoselective C-alkylation of a mefloquine derivative in up to 57% yield was the result of an attempted Williamson etherification of Boc-mefloquine.
Dawid J. Kucharski +1 more
doaj +1 more source
Diastereoselective intramolecular hydride transfer
, 2020 This thesis focuses on the synthetic applications of diastereoselective 1,5-hydride transfer to undergo reduction of transient carbocation, which is generated upon electrophilic activation of alkenes or alcohols.
Gandamana, Dhika Aditya
core +1 more source
Stereoselective Synthesis of 4-O-Tosyltetrahydropyrans via Prins Cyclization Reaction of Enol Ethers
SynOpen, 2019 Intramolecular cyclization of enol ethers mediated by para-toluenesulfonic acid leads to substituted tetrahydropyrans in good to moderate yields. The reaction is diastereoselective.
Sujit Sarkar +4 more
doaj +1 more source
Beilstein Journal of Organic Chemistry, 2013 An Ugi four-component reaction of propargylamine with 3-formylindole and various acids and isonitriles produces adducts which are subjected to a cationic gold-catalyzed diastereoselective domino cyclization to furnish diversely substituted spiroindolines.
Amit Kumar +5 more
doaj +1 more source
Diastereoselective Synthesis of Bicyclopropanes
, 1994 Diastereoselective cyclopropanation of a trans-substituted vinyl cyclopropane was studied. The stereochemistry of the major and minor isomers was assigned by diastereoselective synthesis of the two ...
Cory R. Theberge +3 more
core +1 more source