Results 31 to 40 of about 26,606 (255)

Highly Diastereoselective Asymmetric Thio-Claisen Rearrangements

, 2016
Highly Diastereoselective Asymmetric Thio-Claisen ...
Shuwen He (523841), Sergey A. Kozmin (1350786), Viresh H. Rawal (1323897)   +2 more
core   +4 more sources

1‐Azabicyclo[1.1.0]butanes (ABBs) on the Map: Mechanistic Pathways for Catalytic Ring Opening and Functionalizations

Angewandte Chemie, EarlyView.
Catalytic strain‐release ring opening and functionalizations of 1‐azabicyclo[1.1.0]butanes (ABBs) represent a promising strategy for accessing diverse azetidine products. These transformations proceed via polar pathways, radical pathways, and hybrid mechanisms that combine both.
James Shao‐Jiun Yang, Hsuan‐Hung Liao   +1 more
wiley   +2 more sources

Diastereoselective Addition of Diazomethane to Zaluzanin A [PDF]

Natural Product Communications, 2014
The diastereoselectivity of diazomethane addition to the conjugated double bond of α,β-unsaturated sesquiterpene lactones was explored using zaluzanin A (1) as a model. Thus, the absolute configuration of 1 was assured by X-ray diffraction analysis including evaluation of Flack and Hooft parameters, and by vibrational circular ...
Adriana, Ortiz-León, J Martín, Torres-Valencia, J Jesús, Manríquez-Torres, José G, Alvarado-Rodríguez, Uvaldo, Hernández-Balderas, Carlos M, Cerda-García-Rojas, Pedro, Joseph-Nathan   +6 more
openaire   +2 more sources

Diastereoselective β-Hydroxy Vinylsulfone Isomerizations [PDF]

Vinylic phenylsulfones containing a β-hydroxyl stereocenter undergo a diastereoselective isomerization to the corresponding allylic isomer upon treatment with 1,8-diazabicyclo(5.4.0)undec-7-ene (DBU).
Henry, Crockett, Gregory, O\u27Neil, Calvin, Wallace, Adam, Jones, D. Michael, Carnahan, Trevor, Clark   +5 more
core   +2 more sources

Diastereoselective intramolecular hydride transfer

, 2020
This thesis focuses on the synthetic applications of diastereoselective 1,5-hydride transfer to undergo reduction of transient carbocation, which is generated upon electrophilic activation of alkenes or alcohols.
Gandamana, Dhika Aditya
core   +1 more source

Breakthrough Design of Highly Potent Antivirals Against Wild‐Type HIV‐1 and Lenacapavir‐Resistant M66I Variant

Angewandte Chemie, EarlyView.
Lenacapavir, the first‐in‐class drug targeting HIV‐1 capsid, is a breakthrough drug in HIV‐1 treatment and prophylaxis. However, a single M66I mutation confers complete viral resistance to lenacapavir. We report herein the design and synthesis of innovative R2 analogs demonstrating low nM potency against HIV‐1 M66I and excellent pharmacokinetics in ...
Nicolas Jamey, D. M. Nirosh Udayanga, Huanchun Zhang, Roshan Katekar, Wei Xie, Shreya M. Ravichandran, Xinyong Cai, Zachary C. Lorson, William M. McFadden, Won Hee Ryu, Jiashu Xie, Karen A. Kirby, Stefan G. Sarafianos, Zhengqiang Wang   +13 more
wiley   +2 more sources

Diastereoselective synthesis of 3,4-dihydro-2H-pyran-4-carboxamides through an unusual regiospecific quasi-hydrolysis of a cyano group

Beilstein Journal of Organic Chemistry, 2016
An efficient diastereoselective approach for the synthesis of functionalized 3,4-dihydro-2H-pyran-4-carboxamides with variable frame was developed based on the reaction of available 4-oxoalkane-1,1,2,2-tetracarbonitriles (adducts of TCNE and ketones ...
Mikhail Yu. Ievlev, Oleg V. Ershov, Mikhail Yu. Belikov, Angelina G. Milovidova, Viktor A. Tafeenko, Oleg E. Nasakin   +5 more
doaj   +1 more source

(1R/S,7aS/R)-1-Benzyl-1-[2,8-bis(trifluoromethyl)quinolin-4-yl]-hexahydro-oxazolo[3,4-a]pyridin-3-one

Molbank, 2023
An unexpected diastereoselective C-alkylation of a mefloquine derivative in up to 57% yield was the result of an attempted Williamson etherification of Boc-mefloquine.
Dawid J. Kucharski, Przemysław J. Boratyński   +1 more
doaj   +1 more source

Direct Access to Chiral Piperidines by Enantioselective HAT‐Initiated C(sp3)─H Oxidation

Angewandte Chemie, EarlyView.
The direct desymmetrization of piperidines is achieved through manganese‐catalyzed enantioselective α‐C(sp3)─H oxidation with hydrogen peroxide, affording versatile chiral N,O‐acetals in good yields and with high enantio‐ and diastereoselectivity. These intermediates provide access to diverse functionalized piperidines with retention of chirality ...
Sethuraman Muthuramalingam, Josep M. Luis, Arnau Call, Quentin Lefebvre, Matthew S. Sigman, Miquel Costas   +5 more
wiley   +2 more sources

Stereoselective Synthesis of 4-O-Tosyltetrahydropyrans via Prins Cyclization Reaction of Enol Ethers

SynOpen, 2019
Intramolecular cyclization of enol ethers mediated by para-toluenesulfonic acid leads to substituted tetrahydropyrans in good to moderate yields. The reaction is diastereoselective.
Sujit Sarkar, Namita Devi, Bikoshita Porashar, Santu Ruidas, Anil K Saikia   +4 more
doaj   +1 more source