Enantio- and Diastereoselective Synthesis of Homoallylic α-Trifluoromethyl Amines by Catalytic Hydroalkylation of Dienes [PDF]
, 2020 We describe a strategy for the enantio- and diastereoselective synthesis of homoallylic α-trifluoromethyl amines by the catalytic hydroalkylation of terminal dienes.
Steven, Malcolmson +2 more
core +1 more source
Ag(I)/PPh3-Catalyzed Diastereoselective Syntheses of the Spiro[indole-3,4\u27-piperidine] Scaffold and Its Derivatives via Chelation-Controlled Cycloisomerizations of Tryptamine-Ynamides [PDF]
, 2021 A Ag(I)/PPh3-catalyzed chelation-controlled cycloisomerization of tryptamine-ynamide was developed to access the spiro[indole-3,4\u27-piperidine] scaffold.
Maosheng, Cheng +9 more
core +2 more sources
Diastereoselective Indole-Dearomative Cope Rearrangements by Compounding Minor Driving Forces. [PDF]
, 2022 Reported herein is the discovery of a diastereoselective indole-dearomative Cope rearrangement. A suite of minor driving forces (substrate destabilizing effects; product stabilizing effects) are what promote this otherwise unfavorable dearomatization ...
Subhadip, De +6 more
core +2 more sources
Diastereoselective arylation of l-proline derivatives at the 5-position [PDF]
, 2008 Diastereoselective introduction of nucleophiles into L-proline derivatives at the 5-position was achieved with suitable selection of N-protecting group.
Demizu, Yosuke +5 more
core +1 more source
Highly Enantio- and Diastereoselective Synthesis of Tetrahydrofuran Frameworks via Chiral Lewis Acid-Catalyzed Formal [3+2] Cycloaddition of Allylsilanes. [PDF]
Angew Chem Int Ed EnglThe first catalytic asymmetric formal [3+2] cycloaddition of allylsilanes delivers cis‐2,5‐disubstituted tetrahydrofuran‐3‐ones that serve as versatile intermediates for the synthesis of diverse bioactive scaffolds. ABSTRACT A formal [3+2] cycloaddition via cyclization/1,2‐hydride shift initiated by nucleophilic attack of allylsilanes has been ...
Lee H +5 more
europepmc +3 more sources
Linking Stereocenters Together: Enantio- and Diastereoselective NiH-Catalyzed Hydroalkylation of Internal Alkenes with Racemic Alkyl Electrophiles [PDF]
, 2023 Catalytic methods which control multiple stereogenic centers simultaneously are highly desirable in modern organic synthesis and chemical manufacturing.
Lifu, Wu, Shaolin, Zhu, Jian, Chen
core +2 more sources
Regio- and Diastereoselective Synthesis of Unsymmetrical 1,4-Diketone-Derived (Z)-Monosilyl Enol Ethers via Siloxyallylpotassium Intermediates [PDF]
, 2022 This paper describes the regio- and diastereoselective synthesis of unsymmetrical 1,4-diketone-derived (Z)-monosilyl enol ethers from 1-arylallyloxysilanes and Weinreb amides using (trimethylsilyl)methylpotassium as a base.
Shuto, Okuda +3 more
core +2 more sources
Diastereoselective sulfoximine inhibition of carboxypeptidase A.
, 1991 Diastereoselective sulfoximine inhibition of carboxypeptidase ...
Zuowu (Joyce). Zhang (7960370)
core +6 more sources
Diastereoselective Synthesis of 5-Hydroxy-8-methoxy-1-oxaspiro[5,5]undeca-7,10-diene-9-one
Molecules, 2013 A short five steps synthesis of the title compound from vanillin is described. The racemic spiroether 7 was obtained in 61% yield and in >99% diastereomeric excess (by 1H-NMR) from the corresponding phenolic derivative 3 by oxidation with lead (IV)
Thomas W. Scully, Guy L. Plourde
doaj +1 more source
Nature Communications, 2022 Derivatization of azaarenes can create molecules of biological importance, but reductive functionalization of weakly reactive azaarenes remains a challenge. Here the authors show a dearomative, diastereoselective annulation of azaarenes, via ruthenium(II)
He Zhao +7 more
doaj +1 more source