Results 11 to 20 of about 6,473 (220)

Diastereoselective Synthesis of 5-Hydroxy-8-methoxy-1-oxaspiro[5,5]undeca-7,10-diene-9-one

Molecules, 2013
A short five steps synthesis of the title compound from vanillin is described. The racemic spiroether 7 was obtained in 61% yield and in >99% diastereomeric excess (by 1H-NMR) from the corresponding phenolic derivative 3 by oxidation with lead (IV)
Thomas W. Scully, Guy L. Plourde
doaj   +1 more source

Intermolecular diastereoselective annulation of azaarenes into fused N-heterocycles by Ru(II) reductive catalysis

Nature Communications, 2022
Derivatization of azaarenes can create molecules of biological importance, but reductive functionalization of weakly reactive azaarenes remains a challenge. Here the authors show a dearomative, diastereoselective annulation of azaarenes, via ruthenium(II)
He Zhao, Yang Wu, Chenggang Ci, Zhenda Tan, Jian Yang, Huanfeng Jiang, Pierre H. Dixneuf, Min Zhang   +7 more
doaj   +1 more source

Diastereoselective synthesis of new O-alkylated and C-branched inositols and their corresponding fluoro analogues

Beilstein Journal of Organic Chemistry, 2016
Efficient routes were developed for the diastereoselective synthesis of new O-alkylated and C-branched inositols and their corresponding fluoro analogues.
Charlotte Collet, Françoise Chrétien, Yves Chapleur, Sandrine Lamandé-Langle   +3 more
doaj   +1 more source

Chiral Syn-1,3-diol Derivatives via a One-Pot Diastereoselective Carboxylation/ Bromocyclization of Homoallylic Alcohols

iScience, 2018
Summary: Chiral syn-1,3-diols are fundamental structural motifs in many natural products and drugs. The traditional Narasaka-Prasad diastereoselective reduction from chiral β-hydroxyketones is an important process for the synthesis of these ...
Guanxin Huang, Minjie Liu, Fangjun Xiong, Ge Meng, Yuan Tao, Yan Wu, Haihui Peng, Fener Chen   +7 more
doaj   +1 more source

A Novel Class of “Super‐Strained” Spiro Heterocycles: Gateway to 1‐Azaspiro[3.3]heptane Derivatives, and Biological Validation

Angewandte Chemie, EarlyView.
A new class of “super‐strained” spiro heterocycles—spirocyclic 1‐azabicyclo[1.1.0]butanes—was synthesized via insertion of cyclobutane‐, oxetane‐, and azetidine‐containing sulfonium reagents into substituted azirines. The stability of this new class of compounds was studied.
Philipp Natho, Annarita Vicenti, Marco Colella, Francesco Pasca, Giuseppe Romanazzi, Mauro Niso, Carmen Abate, Ernesto Mesto, Emanuela Schingaro, Renzo Luisi   +9 more
wiley   +2 more sources

Synthesis of dihydrofurans using nano-CuFe2O4@Chitosan

Journal of Saudi Chemical Society, 2017
An efficient multi-component synthesis of dihydrofurans is described by a one-pot condensation reaction of 2,4′-dibromoacetophenone, aromatic aldehydes and dimedone using nano-CuFe2O4@Chitosan under reflux conditions in ethanol.
Javad Safaei-Ghomi, Hossein Shahbazi-Alavi   +1 more
doaj   +1 more source

Strain‐Release Pentafluorosulfanylation of Carbonyl‐Containing Disubstituted Bicyclobutanes: A Fortuitous Path to SF5‐Containing Oxa[2.1.1]bicyclohexanes

Angewandte Chemie, EarlyView.
A regio‐ and diastereoselective method for strain‐release pentafluorosulfanylation of carbonyl‐containing 1,3‐disubstituted [1.1.0]bicyclobutanes (BCBs) was developed that led to several fortuitous discoveries. For instance, the resultant SF5‐cyclobutanes (SF5‐CBs) exhibit close SF5⋯C═X contacts (X = C, N, O) and provide synthetic access to a new class
Alexander M. Stephens, Jake Anthony Olvera, Yannick Kraemer, Tyson Vu, Wang‐Yeuk Kong, Sudiksha Chaturvedi, Jeffrey M. Wang, Lauren M. Holder, Dean J. Tantillo, Cody Ross Pitts   +9 more
wiley   +2 more sources

Three-component coupling of aryl iodides, allenes, and aldehydes catalyzed by a Co/Cr-hybrid catalyst

Beilstein Journal of Organic Chemistry, 2018
The cobalt/chromium-catalyzed three-component coupling of aryl iodides, allenes, and aldehydes has been developed to afford multi-substituted homoallylic alcohols in a diastereoselective manner.
Kimihiro Komeyama, Shunsuke Sakiyama, Kento Iwashita, Itaru Osaka, Ken Takaki   +4 more
doaj   +1 more source

Iridium‐Catalyzed Ionic Hydrogenation of Multi‐Aza Heterocycles

Angewandte Chemie, EarlyView.
Saturated nitrogen‐containing heterocycles are ubiquitous in bioactive molecules and are thus attractive synthetic targets. A readily accessible cyclometalated iridium(III) complex reduces 14 different aromatic aza heterocycles to (partially)saturated multi aza‐heterocycles enlarging accessible chemical space while displaying high tolerance toward ...
Arthur Despois, Nicolai Cramer
wiley   +2 more sources

Pd/C‐Catalyzed Hydrogenation of CF3‐, CF2H‐, and CF2CO2Et‐containing Pyridines: A Robust Method for Highly Functionalized containing Piperidines

Angewandte Chemie, EarlyView.
A robust and efficient method to access diversely functionalized fluorinated piperidines was developed. The approach features the hydrogenation of polysubstituted pyridines bearing CF3, CF2H, and CF2CO2Et substituents using an inexpensive, readily available heterogeneous Pd/C catalyst under air‐ and moisture‐tolerant conditions, offering an appealing ...
Thibaud Charvillat, Patrick Bernardelli, Marc Daumas, Xavier Pannecoucke, Vincent Ferey, Hassan Oulyadi, Muriel Sebban, Tatiana Besset   +7 more
wiley   +2 more sources