Results 41 to 50 of about 13,428 (198)

Plant Metabolites Screening Identifies 7‐epi‐10‐Deacetyltaxol Inhibiting Cell Division by Interfering With the Cell Cycle and Microtubule Organization

Advanced Science, EarlyView.
In this study, an efficient screening system is developed for plant metabolites to find a compound, 7‐epi‐10‐deacetyltaxol, inhibits tissue elongation. It suppresses plant growth through brassinosteroid and microtubule pathways. It is later applied to animal cells and human tumor organoids, resulting in similar cell division suppression. These findings
Yan‐Jie Zhang, Yu‐Xuan Bai, Geng G. Tian, Bin Zhang, Ding‐Yi Lu, Qing‐Ping Yao, Wen‐Hao Tian, Xiao‐Na Wei, Jing‐Ting Yang, Ze‐Yu Xiong, Yi Lu, Yu‐Tong Jiang, Chun‐Hui Cai, Yu‐Ming Lu, Xian‐Qing Jia, Li‐Li Jing, Bao‐Jun Yang, Ying‐Xin Qi, Xin‐Xin Han, Ji Wu, Wen‐Hui Lin   +20 more
wiley   +1 more source

Accelerating Primary Screening of USP8 Inhibitors from Drug Repurposing Databases with Tree‐Based Machine Learning

Advanced Intelligent Discovery, EarlyView.
This study introduces a tree‐based machine learning approach to accelerate USP8 inhibitor discovery. The best‐performing model identified 100 high‐confidence repurposable compounds, half already approved or in clinical trials, and uncovered novel scaffolds not previously studied. These findings offer a solid foundation for rapid experimental follow‐up,
Yik Kwong Ng, Sharon Ai Er Lam, Wei Chun Lim, Hannah Hui Min Toh, Shi Jun Ang   +4 more
wiley   +1 more source

Stereoisomerism‐controlled Packing in Ladder‐type Indacenodithieno[3,2‐b]thiophene Crystals

Aggregate
Stereochemistry is a potent way to direct the molecular packing in condensed phases. Here, we synthesized the enantiopure, racemic, and achiral isomers of p‐type small molecule, that is, indacenodithieno[3,2‐b]thiophene, to understand the impact of ...
Meenal Kataria, Masaki Nobuoka, Yusuke Tsutsui, Takayuki Tanaka, Rajendra Prasad Paitandi, Yuta Takemasa, Wookjin Choi, Shu Seki   +7 more
doaj   +1 more source

A new bonded silica based on an amino acid derivative as a TLC stationary phase to solve nitrophenol structural isomerism and ibuprofen stereoisomerism

Future Journal of Pharmaceutical Sciences, 2020
Background Many amino acids and their derivatives have been used previously as chiral selectors in thin layer chromatography. Herein, we reported the synthesis, characterization, and chromatographic evaluation of a new modified stationary phase based on (
Mouhammad Abu Rasheed, Ahmad Alshaghel, Amir Alhaj Sakur   +2 more
doaj   +1 more source

Scientific Opinion on Flavouring Group Evaluation 11, Revision 3 (FGE.11Rev3): Aliphatic dialcohols, diketones, and hydroxyketones from chemical groups 8 and 10

EFSA Journal, 2014
The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate 11 flavouring substances in the Flavouring Group Evaluation 11, Revision 3, using the Procedure in Commission ...
EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids
doaj   +1 more source

Preclinical characterisation of gallium-68 labeled ferrichrome siderophore stereoisomers for PET imaging applications

EJNMMI Radiopharmacy and Chemistry
Background Siderophores are small iron-binding molecules produced by microorganisms to facilitate iron acquisition from the environment. Radiolabelled siderophores offer a promising solution for infection imaging, as they can specifically target the ...
Kristyna Krasulova, Barbora Neuzilova, Katerina Dvorakova Bendova, Zbynek Novy, Miroslav Popper, Marian Hajduch, Milos Petrik   +6 more
doaj   +1 more source

THE STEREOCHEMISTRY AND CONFORMATION OF LIGNIN AS JUDGED BY X-RAY CRYSTALLOGRAPHIC INVESTIGATIONS OF LIGNIN MODEL COMPOUNDS: ARYLGLYCEROL BETA-GUAIACYL ETHERS

BioResources, 2007
The conformations of a variety of crystalline lignin models representing different diastereomeric forms of structural elements in lignin of the arylglycerol -guaiacyl ether type have been studied using X-ray crystallography.
Jim Parkås, Knut Lundquist, Vratislav Langer   +2 more
doaj  

Comparative Study Related to Cardiovascular Safety between Bupivacaine (S75-R25) and Ropivacaine in Brachial Plexus Block

Brazilian Journal of Anesthesiology, 2013
Background and objectives Bupivacaine is a first choice for regional anesthesia considering its effectiveness, long duration and less motor blockade.
Adilson Hamaji, Marcelo Rosa de Rezende, Rames Mattar, Jr., Joaquim Edson Vieira, José Otávio Costa Auler, Jr.   +4 more
doaj   +1 more source

Near‐infrared light‐activated aptamer‐based nanoprobe for spatiotemporally resolved detection of L‐lactate in colorectal cancer

BMEMat, EarlyView.
A near‐infrared (NIR) light‐activated “lock‐key” nanodevice is reported for spatiotemporally resolved detection of intratumoral L‐lactate. The system stays silent until deep‐penetrating NIR light remotely unlocks its function, allowing for precise sensing within tumors.
Siyu Pan, Xuanyi Lu, Wenjie Yang, Yunhui Peng, Lingfu Deng, Shuai Zha, Xueyang Fang, Guochen Bao, Lijun Jiang   +8 more
wiley   +1 more source

Alkali cation-π interactions in aqueous systems, modulating supramolecular stereoisomerism of nanoscopic metal-organic capsules

Nature Communications
Contrary to common chemical intuition, cation-π interactions can persist in polar, aqueous reaction solutions, rather than in dry non-coordinative solvent systems.
Paul Wix, Swetanshu Tandon, Sebastien Vaesen, Kadri Karimu, Jennifer S. Mathieson, Kane Esien, Solveig Felton, Graeme W. Watson, Wolfgang Schmitt   +8 more
doaj   +1 more source