Results 51 to 60 of about 13,728 (257)

Streptavidins Coordinate Biotin Sequestration and Self‐Resistance Within a Biotin‐Pathway Antibiotic Network

open access: yesAdvanced Science, EarlyView.
A conserved genomic region between two streptavidin genes in Streptomyces packages biosynthetic gene clusters for diverse biotin‐pathway antibiotics: acidomycin, stravidin, the new non‐proteinogenic amino acid ANDA, and the new BioA inhibitor α‐methyl‐KAPA.
Sumire Kurosawa   +8 more
wiley   +1 more source

Host–guest interactions in nor-seco-cucurbit[10]uril: novel guest-dependent molecular recognition and stereoisomerism

open access: yesBeilstein Journal of Organic Chemistry, 2019
The unique monomer and excimer fluorescence emissions of pyrene were first exploited as distinctly photophysical signals to identify the possible diastereomers of guests within nor-seco-cucurbit[10]uril (NS-CB[10]) cavities.
Xiaodong Zhang   +3 more
doaj   +1 more source

Scientific Opinion on Flavouring Group Evaluation 82, Revision 1 (FGE.82Rev1): Consideration of Epoxides evaluated by the JECFA (65th meeting) [PDF]

open access: yesEFSA Journal, 2014
The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to consider evaluations of flavouring substances assessed since 2000 by the Joint FAO/WHO Expert Committee on Food Additives
EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF)
doaj   +1 more source

Mechanical Activation of Piezo1 Drives Osteoarthritis Through Kdm5c‐Mediated Epigenetic Silencing

open access: yesAdvanced Science, EarlyView.
Excessive mechanical stress activates Piezo1, triggering Ca2+‐dependent cytoskeletal forces that deform the nucleus and reduce H3K4me3. Kdm5c demethylates H3K4me3 at Col2a1 and Runx3 promoters. Kdm5c knockout rescues degradation. Repurposed telmisartan directly inhibits Kdm5c, blocking this axis and showing disease‐modifying efficacy in mouse OA models
Tianyou Kan   +13 more
wiley   +1 more source

PECULIARITIES OF SEASON BIORHYTHMS IN DIFFERENT PARTS OF FUNCTIONAL SYSTEM MOTHER-PLACENTA-FETUS IN DEPENDENCE ON ITS STEREOFUNCTIONAL ORGANIZATION IN PHYSIOLOGICAL AND COMPLICATED PREGNANCY

open access: yesМедицинский вестник Юга России, 2013
Purpose: studying seasonal periodicity of stereoisomerism of uteroplacental complex, the dynamics of body weight of infants, studying the chronostructure of mezorhythms of contractive activity of right and left parts of the uterus.Material and Methods ...
N. A. Rogova   +4 more
doaj   +1 more source

Stereoisomere Phenylbrommilchsäuren [PDF]

open access: yesBerichte der deutschen chemischen Gesellschaft, 1899
n ...
Erlenmeyer, E., Moebes, A.
openaire   +2 more sources

Nickel‐Free Synthesis of Poly(pyrene‐4,5,9,10‐tetraone) for Sodium‐based Batteries: Insights into Electrode Architecture and Reversible Na‐ion Insertion

open access: yesAdvanced Energy Materials, EarlyView.
A nickel‐free and practical synthesis strategy to poly(pyrene tetraone) and its integration with a percolated CNTs/Ketjen Black network enables stable cycling and efficient energy storage in a sodium‐based batteries. This work demonstrates how controlling polymer structure and electrode architecture improves ion transport and mitigates dissolution in ...
Md. Adil   +9 more
wiley   +1 more source

Accelerating Primary Screening of USP8 Inhibitors from Drug Repurposing Databases with Tree‐Based Machine Learning

open access: yesAdvanced Intelligent Discovery, EarlyView.
This study introduces a tree‐based machine learning approach to accelerate USP8 inhibitor discovery. The best‐performing model identified 100 high‐confidence repurposable compounds, half already approved or in clinical trials, and uncovered novel scaffolds not previously studied. These findings offer a solid foundation for rapid experimental follow‐up,
Yik Kwong Ng   +4 more
wiley   +1 more source

Anti-atherosclerotic activity of catechins depends on their stereoisomerism

open access: yes, 2015
In terms of stereochemistry, catechins are divided into two groups: (-) epi forms (2R, 3R) and (-) forms (2S, 3R). Most of the catechins present in green tea are (-) epi forms (2R, 3R).
Maślak, Edyta   +4 more
core   +1 more source

Stereoisomerism of Molecular Multipropellers. 1. Static Stereochemistry of Bis- and Tris-triaryl Systems

open access: yes, 2016
The static stereoisomerism of bis- and tris-triaryl systems has been analyzed by a systematic stereochemical analysis, and the resulting theoretical predictions have been experimentally confirmed by using reversed-phase HPLC and ESR and 1H NMR ...
Josep Sedó (2955072)   +5 more
core   +1 more source

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