Results 61 to 70 of about 116,777 (208)
Unique Structure−Activity Relationship for 4-Isoxazolyl-1,4-dihydropyridines
, 2016 A series of 4-isoxazolyl-1,4-dihydropyridines (IDs) were prepared and characterized, and their interaction with the calcium channel was studied by patch clamp analysis.
Alex Blumenfeld (2306734) +7 more
core +1 more source
Chemoenzymatic Synthesis of Enantiopure 1,4‐Dihydropyridine Derivatives
ChemInform, 2004 AbstractFor Abstract see ChemInform Abstract in Full Text.
Sobolev, A. +3 more
openaire +2 more sources
The Chemical Record, EarlyView.This review highlights recent advances in the use of organic carbonates, dimethyl carbonate (DMC), diethyl carbonate (DEC), and propylene carbonate (PC), as solvents in organic synthesis. Based on over seventy studies from the past 6 years, it shows their application in different organic reaction types, emphasizing their role in safer and more ...
Gabriela T. Quadros +5 more
wiley +1 more source
The Diarylprolinol Silyl Ethers: After 20 Years Still Opening New Doors in Asymmetric Catalysis
Angewandte Chemie, Volume 138, Issue 11, 9 March 2026.Catalysis Rules! The year 2025 marks the 20th anniversary of diarylprolinol silyl ethers in asymmetric organocatalysis. During the first decade after their discovery, these catalysts have been established as one of the most versatile tools in aminocatalysis. Although now considered mature, recent years have witnessed renewed innovation.
Enrico Marcantonio +2 more
wiley +2 more sources
A Combined MS/MS and IMS Study Into the Fragmentation Pathway of Nifedipine
Journal of Mass Spectrometry, Volume 61, Issue 7, July 2026.ABSTRACT Collision‐induced dissociation (CID) of small molecules, typically with a molecular mass below 1500 Da, is widely applied for the structural identification of drug metabolites, synthetic by‐products and unknown compounds. Nonetheless, the interpretation of MS/MS spectra derived from protonated or sodiated molecules mainly relies on the ...
Peiliang Han +2 more
wiley +1 more source
Intramolecular hydrogen bonds in 1,4-dihydropyridine derivatives [PDF]
Royal Society Open Science, 2018 1,4-Dihydropyridine (1,4-DHP) derivatives have been synthesized and characterized by 1 H, 13 C, 15 N nuclear magnetic resonance (NMR) spectroscopy, secondary proton/deuterium 13 C isotope shifts, variable temperature 1 H ...
M. Petrova +4 more
openaire +3 more sources
Medicinal Research Reviews, Volume 46, Issue 4, Page 1173-1229, July 2026.ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur +6 more
wiley +1 more source
Recent Approaches for the Synthesis of Pyridine and Quinoline Cores Present in Natural Products
Advanced Synthesis &Catalysis, Volume 368, Issue 10, 19 May 2026.An anthology of the most recent methods used to synthesize pyridines and quinolines found in natural products over the last decade. Pyridines, quinolines, and their derivatives represent a class of significant heterocyclic compounds that are prevalent in a multitude of natural products, including alkaloids found in plants, fungi, insects, marine ...
Carl Bowman +2 more
wiley +1 more source
Dearomatization with Axial‐to‐Central Chirality Conversion
European Journal of Organic Chemistry, Volume 29, Issue 17, 5 May 2026.Atropisomers are exciting synthetic targets with unique properties, which find applications in many fields of chemistry. However, considering them as substrates is not very frequent, notably in the context of dearomatization reaction. We wish to discuss the different strategies for the dearomatization of aromatic atropisomers with axial‐to‐central ...
Morgane Mando +3 more
wiley +1 more source
Evaluation of the reaction mechanism between 1,4-dihydropyridines and α,β-unsaturated nitriles.
, 2022 Hydride transfer reactions involving 1,4-dihydropyridines play a central role in bioorganic chemistry as they represent an important share of redox metabolism.
Esteban, Vöhringer-Martinez +2 more
core +1 more source