Results 81 to 90 of about 5,082 (203)

Benign synthesis of therapeutic agents: domino synthesis of unsymmetrical 1,4-diaryl-1,4-dihydropyridines in the ball-mill

Green Chemistry Letters and Reviews, 2022
The solvent-free preparation of unsymmetrical N-aryl-5,6-unsubstituted-1,4-dihydropyridines (DHPs) by ball-milling was investigated. Three different mechanochemical domino reactions (one-pot/one step or stepwise) were studied, the process parameters ...
Cristina Blazquez-Barbadillo, Juan Francisco González, Andrea Porcheddu, David Virieux, José Carlos Menéndez, Evelina Colacino   +5 more
doaj   +1 more source

Dihydropyridine derivatives modulate heat shock responses and have a neuroprotective effect in a transgenic mouse model of Alzheimer’s disease [PDF]

, 2016
Heat shock proteins (Hsps) have chaperone activity and play a pivotal role in the homeostasis of proteins by preventing misfolding, by clearing aggregated and damaged proteins from cells and by maintaining proteins in an active state. Alzheimer’s disease
Balogh, Gábor, Bernáth, Sándor, Blundell, Katie L I M, Bálind, Árpád, Frank, Zsuzsa, Fülöp, Ferenc, Hooper, Philip L, Horváth, Ibolya, Hunya, Ákos, Kasza, Ágnes, Penke, Botond, Prodromou, Chrisostomos, Sántha, Miklós, Török, Zsolt, Vigh, László, Zeiler, Hans-Joachim   +15 more
core   +1 more source

Hydrogen Transfer from Hantzsch 1,4-Dihydropyridines to Carbon-Carbon Double Bonds under Microwave Irradiation

Molecules, 2002
1,4-Dihydropyridines (DHPs) have been used in the reduction of carbon-carbon double bonds under microwave irradiation without solvent. The efficiency of the reactions is dramatically dependent on the steric effects in the DHPs and on the electronic ...
Jean Jacques Vanden Eynde, Didier Barbry, Guy Cordonnier, Séverine Torchy   +3 more
doaj   +1 more source

Breakthroughs in Medicinal Chemistry: New targets and mechanisms, new drugs, new hopes [PDF]

, 2017
The Editorial Board of the Medicinal Chemistry section of the journal Molecules publishes here its first Editorial, which has been prepared by highlighting, in sub-editorials of about one hundred words, some selected recently published articles that may ...
Agrofoglio, Luigi A., Collina, Simona, Guillou, Catherine, Gütschow, Michael, Hulme, Christopher, Karaman, Rafik, Kokotos, George, Liu, Hong, Luque Garriga, F. Xavier, Mangoni, Arduino A., Muñoz-Torrero López-Ibarra, Diego, Prokai-Tatrai, Katalin, Ragno, Rino, Rautio, Jarkko, Sabatier, Jean-Marc, Siciliano, Carlo, Sousa, Maria Emília de   +16 more
core   +4 more sources

Bis‐Furans: A Sustainable Source of Diverse Molecular Architectures

European Journal of Organic Chemistry, Volume 29, Issue 10, 9 March 2026.
A concise synthetic route to diverse acyclic and heterocyclic compounds has been developed by combining hetero‐Diels–Alder reactions, DBU‐promoted ring openings, and Lewis base‐catalyzed annulations. Nitrosoalkenes reacted with furan derivatives to form 4a,7a‐dihydro‐4H‐furo[2,3‐e][1,2]oxazines, which underwent DBU‐promoted rearrangements to 6H‐1,2 ...
Ana L. Cardoso, José A. Paixão, Teresa M. V. D. Pinho e Melo   +2 more
wiley   +1 more source

First Organocatalytic Asymmetric Synthesis of 1-Benzamido-1,4-Dihydropyridine Derivatives

Molecules, 2018
Preliminary results concerning the first asymmetric synthesis of highly functionalized 1-benzamido-1,4-dihydropyridine derivatives via the reaction of hydrazones with alkylidenemalononitriles in the presence of β-isocupreidine catalyst are reported.
Fernando Auria-Luna, Eugenia Marqués-López, Raquel P. Herrera   +2 more
doaj   +1 more source

A facile synthesis of N-H-and N-substituted acridine-1,8-diones under sonic condition [PDF]

, 2013
Synthesis of an assembly of structurally important N-H- and N-substituted acridine-1,8-diones by CAN (ceric ammonium nitrate) catalysed one-pot four-component reaction of electron-deficient and electron-rich aromatic aldehydes and aromatic amines or ...
Pasha, M.A., Sudha, S.
core   +3 more sources

Radical Retrosynthesis of Natural Products Enabled by Iron‐Based Reductive Olefin Coupling

Angewandte Chemie Novit, Volume 2, Issue 1, March 2026.
This review highlights iron‐catalyzed reductive olefin coupling (ROC)—a strategy for C─C bond formation driven by metal‐hydride hydrogen atom transfer (MHAT)—as a key tool in natural products synthesis. This review surveys dozens of total syntheses employing ROC‐based strategies, highlighting its power to forge strained rings, quaternary centers, and ...
Griffin L. Barnes, Alex L. Rerick, Phil S. Baran   +2 more
wiley   +1 more source

Who Lives in a Tin Can Under the (Ultrasonic) Sea: Sponges Made From Perfluoropyridine‐Derived Thiol‐Ene Polymerizations

Journal of Polymer Science, Volume 64, Issue 4, Page 833-847, 15 February 2026.
Tandem mechanochemical‐sonochemical for the strategic synthesis for 2,4,6‐trisubstituted derivatives of perfluoropyridine as bio‐based prepolymer materials. ABSTRACT Substitution of perfluoropyridine (PFP) in the 4‐position through an SNAr reaction is facile through mechanochemical methods, with yields in excess of 99% and short reaction times on a ...
Jason Pulfer, Miriam Aldom, Maxime Colpaert, Andrea Kelley, Tim Storr, Chadron M. Friesen   +5 more
wiley   +1 more source

Recent Advances in Bioconjugation of Aromatic Amino Acid Residues by a Reactivity‐Guided Approach

The Chemical Record, Volume 26, Issue 2, February 2026.
This review highlights recent advances in the bioconjugation of aromatic amino acids residues, focusing on strategies that leverage their inherent chemical reactivity to enable precise and versatile modifications of biomacromolecules, illustrating relevant applications.
Bruno M. da S. Santos, Lívia C. R. M. da Frota, Thais G. Silva, Fernanda G. Finelli   +3 more
wiley   +1 more source