Results 81 to 90 of about 116,777 (208)
Drug Development Research, Volume 87, Issue 2, April 2026.ABSTRACT Hexahydroquinoline (HHQ) is a widely recognized scaffold that has garnered considerable attention owing to its diverse pharmacological properties. The structure of HHQ includes a 1,4‐dihydropyridine (DHP) ring, which serves as the pharmacophore for the predominant class of drugs known as calcium channel blockers.
Ebru Koçak Aslan +13 more
wiley +1 more source
First Organocatalytic Asymmetric Synthesis of 1-Benzamido-1,4-Dihydropyridine Derivatives
Molecules, 2018 Preliminary results concerning the first asymmetric synthesis of highly functionalized 1-benzamido-1,4-dihydropyridine derivatives via the reaction of hydrazones with alkylidenemalononitriles in the presence of β-isocupreidine catalyst are reported.
Fernando Auria-Luna +2 more
doaj +1 more source
ChemistryOpen, Volume 15, Issue 4, April 2026.In organic synthesis, deep eutectic solvents (DES) have demonstrated their ability to be used as reaction media for the development of reactions in line with green chemistry principles. This review presents an overview of microwave‐assisted organic synthesis in DES, highlighting the diversity of uses for these solvents, their role in mechanisms, the ...
Pierre‐Olivier Delaye +2 more
wiley +1 more source
Synthesis, spectroscopic characterization, X-ray structure, and DFT calculations of some new 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxamides. [PDF]
PLoS ONE, 2014 A series of novel 1,4-dihydro-2,6- dimethyl-3,5-pyridinedicarboxamides were synthesized and characterized by infrared absorption spectrum (IR), proton nuclear magnetic resonance (1H NMR), elemental analysis, ultraviolet spectrum (UV), and fluorescence ...
Yi Li +4 more
doaj +1 more source
, 1993 The synthesis and in vitro calcium channel blocking activities and binding of 2-(ω- aminoalkylthiomethyl)-4-(substituted)phenyl-1,4-dihydropyridines, by determination of the displacement of [3H]nitrendipine from the calcium channel binding sites on rat ...
Christiaans, JAM +4 more
core +1 more source
Design and synthesis of novel 4-substituted 1,4-dihydropyridine derivatives as hypotensive agents
Journal of Saudi Chemical Society, 2016 Calcium-channel blockers have an important role in the treatment of several cardiovascular disorders. Derivatives of 1,4-dihydropyridines are one of the most potent calcium antagonists.
Prasanna A. Datar, Pratibha B. Auti
doaj +1 more source
Sodium Hypochlorite-Dowex 1X8-200: A Convenient Oxidizing Reagant [PDF]
Iranian Journal of Chemistry & Chemical Engineering, 2002 The polymer supported hypochlorite ion is a facile selective oxidizing agent for the oxidation of various alcohols to aldehydes and ketones. Similarly is successfully oxidizes various Hantzsch type 1,4- dihydropyridines to corresponding pyridines.
Mahammad Mahmoodi Hashemi +1 more
doaj
Oxidative aromatization of Hantzsch 1,4-dihydropyridines by sodium chlorite
, 2010 Hantzsch 1,4-dihydropyridines were converted to the corresponding pyridines efficiently by sodium chlorite under mild conditions in excellent yields. (C) 2010 Elsevier Ltd.
Lin, Wenbin +4 more
core
Iron(III) phosphate catalyzed synthesis of 1,4-dihydropyridines
, 2014 Novel 1,4-dihydropyridines (1,4-DHPs) are prepared efficiently via Hantzsch reaction using aldehydes, benzylacetoacetate and catalytic amount of iron(III) phosphate under solvent-free conditions in good ...
Yazdanparast, Banafsheh +1 more
core +1 more source
Bis‐Furans: A Sustainable Source of Diverse Molecular Architectures
European Journal of Organic Chemistry, Volume 29, Issue 10, 9 March 2026.A concise synthetic route to diverse acyclic and heterocyclic compounds has been developed by combining hetero‐Diels–Alder reactions, DBU‐promoted ring openings, and Lewis base‐catalyzed annulations. Nitrosoalkenes reacted with furan derivatives to form 4a,7a‐dihydro‐4H‐furo[2,3‐e][1,2]oxazines, which underwent DBU‐promoted rearrangements to 6H‐1,2 ...
Ana L. Cardoso +2 more
wiley +1 more source