Results 91 to 100 of about 5,082 (203)

Decoding Urease Inhibition: A Comprehensive Review of Inhibitor Scaffolds

ChemMedChem, Volume 21, Issue 2, January 2026.
Representative functional groups known for urease inhibition are reviewed within diverse scaffolds using structure–activity analyses to identify features associated with high inhibitory activity. Urease is a metalloenzyme produced by a wide range of organisms and plays a critical role in nitrogen microbial metabolism by catalyzing the hydrolysis of ...
Nuno Martinho, Natália Aniceto
wiley   +1 more source

Transfer Hydrogenation: Advances in Manganese and Nickel Metal Catalysis

Journal of Chemistry, Volume 2026, Issue 1, 2026.
Transfer hydrogenation (TH) of ketones, catalyzed by transition–metal complexes, produces alcohols, which are important building blocks in the pharmaceutical and fine chemical industries. For a long time, catalysts based on noble metals such as ruthenium, rhodium, and iridium have dominated the TH of ketones.
James Kamau, George S. Nyamato, Joanne Ogunah, Munmun Bardhan   +3 more
wiley   +1 more source

Tertiary Alcohols as Radical Precursors for the Introduction of Tertiary Substituents into Heteroarenes [PDF]

, 2019
Despite many recent advances in the radical alkylation of electron-deficient heteroarenes since the seminal reports by Minisci and co-workers, methods for the direct incorporation of tertiary alkyl substituents into nitrogen heteroarenes are limited ...
Fishman, DA, Muuronen, M, Overman, LE, Pitre, SP   +3 more
core   +2 more sources

Establishment and Partial Characterization of an Epirubicin-Resistant Gastric Cancer Cell Line with Upregulated ABCB1 [PDF]

, 2014
Multidrug resistance (MDR) is a major impediment to successful chemotherapy of gastric cancer. Our aim was to establish an epirubicin-resistant cell subline (AGS/EPI) and to elucidate the mechanisms involved in acquired EPI resistance.
Felipe, Aledson Vitor, Forones, Nora Manoukian, Moraes, Andrea Aparecida, Oliveira, Juliana de, Silva, Tiago Donizetti da   +4 more
core   +2 more sources

Recent Synthetic Advances in C–H/N–H Functionalization of 1H‐Pyrazoles: Diverse Strategies Across Variously Substituted Scaffolds

The Chemical Record, Volume 25, Issue 12, December 2025.
Systematic overview of pyrazole functionalization reactions from C‐5 to N−H. It covers different strategies, from traditional cross‐coupling of prefunctionalized pyrazoles to more efficient direct functionalizations. This review briefly and systematically overviews C–H and N–H functionalization reactions of pyrazoles, aimed at creating new CC and C ...
Karolina Dzedulionytė Müldür, Asta Žukauskaitė, Algirdas Šačkus, Eglė Arbačiauskienė   +3 more
wiley   +1 more source

Chemistry, Applications, and Synthesis Methods of Indole Derivatives: A Comprehensive Review

The Chemical Record, Volume 25, Issue 12, December 2025.
Indole and its derivatives represent a vital class of heterocycles with broad applications in pharmaceuticals, agrochemicals, and materials science. This review explores their applications, biosynthesis, key derivatives such as tryptophan, and presents an overview of both classical and modern synthetic methodologies, with a focus on sustainable ...
Raphael Silva Moratório de Moraes, Ana Beatriz Mestre Botelho, Gabriel Tavares de Almeida Pinto, Searitha Couto Rodrigues, Maria Tereza Miranda Martins, Deivid Lucas Alves Soares, Camille Cardoso Cruz, Aline de Almeida Pinto, Flaviana Rodrigues Fintelman Dias, Patricia Dias Fernandes, Anna Claudia Cunha   +10 more
wiley   +1 more source

Antischistosomal Activity of 1,4-Dihydropyridines

Drugs and Drug Candidates
Background/Objectives: Recent reports have demonstrated the antiparasitic activity of 1,4-dihydropyridine (1,4-DHPs). This study aimed to assess the in vitro antischistosomal activity of 24 1,4-DHPs against Schistosoma mansoni adult worms.
Thaís A. S. Oliveira, Matheus H. M. Zago, Larissa G. Maciel, Yan R. Robles, Lizandra G. Magalhães, Antônio E. M. Crotti   +5 more
doaj   +1 more source

1,4-Dihydropyridines: Reactivity of nitrosoaryl and nitroaryl derivatives with alkylperoxyl radicals and ABTS radical cation [PDF]

, 2004
In the present paper, a direct quenching of radical species by a number of synthesized nitrosoaryl 1,4-dihydropyridines and their parent nitroaryl 1,4-dihydropyridines was determined in aqueous media at pH 7.4. These two series of compounds were compared
Camargo Grandón, Rodrigo, López Alarcón, Camilo, Núñez Vergara, Luis, Santander, P., Squella Serrano, Juan, Valenzuela, V.   +5 more
core   +1 more source

Photodecomposition of a New 1,4-Dihydropyridine: Furnidipine

Journal of Pharmaceutical Sciences, 1994
The photodecomposition of new 1,4-dihydropyridine, furnidipine (CRE-319); [2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-tetrahydrofurfuryl 5-methyl diester) was studied by voltammetric, UV-vis spectrophotometric, and HPLC technique with three different light conditions (artificial daylight, UV light, and room daylight ...
Núñez Vergara, Luis, Sunkel, Carlos, Squella Serrano, Juan   +2 more
openaire   +3 more sources

Meglumine catalyzed one-pot green synthesis of novel 4,7-dihydro-1H-pyrazolo3,4-bpyridin-6-amines [PDF]

, 2017
Meglumine efficiently catalyzes the one-pot, five-component reaction of hydrazine, ethyl acetoacetate, aryl aldehydes, substituted phenylacetonitriles and ammonium acetate in ethanol at room temperature to afford novel 4,7-dihydro-1H-pyrazolo3,4-bpyridin-
Govindaraju, S., Khan, R.-U.-R., Pasha, M.A., Tabassum, S.   +3 more
core   +1 more source