Results 71 to 80 of about 5,082 (203)

A low-voltage activated, transient calcium current is responsible for the time-dependent depolarizing inward rectification of rat neocortical neurons in vitro [PDF]

, 1987
Intracellular recordings were obtained from rat neocortical neurons in vitro. The current-voltage-relationship of the neuronal membrane was investigated using current- and single-electrode-voltage-clamp techniques.
A Constanti, A Constanti, A Finkelstein, BA Vogt, Bernd Sutor, BW Connors, CE Stafstrom, CE Stafstrom, CE Stafstrom, CE Stafstrom, D Johnston, DA McCormick, E Carbone, F Crepel, H Jahnsen, H Jahnsen, H Jahnsen, H Jahnsen, JR Hotson, JR Howe, JR Howe, JV Halliwell, K Murase, ML Mayer, P Adams, P Franz, P Schwindt, PG Nelson, R Llin�s, R Llin�s, R Llin�s, R Llin�s, RJ Docherty, S Hagiwara, SA Fedulova, W Rall, W Rall, Walter Zieglg�nsberger   +37 more
core   +1 more source

Conformation of 1,4‐dihydropyridine — planar or boat‐like? [PDF]

FEBS Letters, 1988
The geometry of the 1,4‐dihydropyridine molecule was completely optimized employing three different ab initio basis sets (6–31 G*, 4–31 G, STO—3G). The most reliable 6–31G* basis set provides a very flat boat conformation which may easily undergo defolding to a planar ring arrangement.
H. Hofmann, CIMIRAGLIA, Renzo
openaire   +2 more sources

Mineralocorticoid receptor antagonists: Efficacy and safety in chronic kidney disease

Diabetes, Obesity and Metabolism, Volume 28, Issue 5, Page 3568-3581, May 2026.
Abstract The mineralocorticoid receptor (MR) has a multifaceted role in normal physiologic functions. However, research has uncovered the deleterious consequences of overactivation of the MR. It has been implicated in chronic kidney disease (CKD) via its strong association with glomerulosclerosis, interstitial fibrosis, proteinuria, and decline in ...
Amy K. Mottl, Kamlesh Khunti, Chantal Mathieu   +2 more
wiley   +1 more source

Ca2+ transients are not required as signals for long-term neurite outgrowth from cultured sympathetic neurons [PDF]

, 1990
A method for clamping cytosolic free Ca2+ ([Ca2+]i) in cultures of rat sympathetic neurons at or below resting levels for several days was devised to determine whether Ca2+ signals are required for neurite outgrowth from neurons that depend on Nerve ...
Murrell, R D, Suidan, H S, Tolkovsky, A M, Walker, A E   +3 more
core   +2 more sources

Organophotoredox/Cobalt‐Catalyzed Retro‐Hydroformylation of Aldehydes

ChemistryEurope, Volume 4, Issue 4, April 2026.
A new photoredox/cobalt retro‐hydroformylation is developed. This one‐pot two‐step process involves the in situ formation of the corresponding 1,4‐dihydropyridine as key intermediate. Under mild reaction conditions, alkenes are efficiently produced from a wide range of aliphatic α‐monosubstituted aldehydes, with high functional‐group tolerance.
Augustin Nouaille, Emmanuel Magnier, Corinne Gosmini, Guillaume Dagousset   +3 more
wiley   +1 more source

Preparation of indole alkaloids via 1,4-dihydropyridine stage or cyano-masked iminium intermediates [PDF]

, 2004
Methods to synthesise substituted pyridine derivatives utilising 1,4-dihydropyridines were studied. Addition of nucleophiles to N-alkyl pyridinium salts and application of the products to alkaloid synthesis were investigated.
Putkonen, Tiina
core  

Repurposing drugs to fast-track therapeutic agents for the treatment of cryptococcosis [PDF]

, 2018
Many infectious diseases disproportionately affect people in the developing world. Cryptococcal meningitis is one of the most common mycoses in HIV-AIDS patients, with the highest burden of disease in sub-Saharan Africa.
Afeltra, Bicanic, Butts, Byrnes, Catterall, Ceballos, Chatterji, Chong, Chrysant, Clinical and Laboratory Standards Institute (CLSI), Clinical and Laboratory Standards Institute (CLSI), Cruz, Cruz, Cumino, Dehdashti, Del Poeta, Dzoyem, Edlind, Espinel-Ingroff, Feldmeier, Gaggi, Hagen, Hong, Hong, Horton, Jarvis, Joffe, Kneale, Lai, Lassègue, Liu, Liu, Loyse, Meiring, Nixon, Oprea, Park, Peiter, Perfect, Prole, Rabjohns, Rajasingham, Rhein, Samantaray, Smith, Spagnuolo, Spitzer, Teng, Téllez-Girón, Zhai, Zhai   +50 more
core   +3 more sources

Hexahydroquinoline Featuring Amide Functionality: A Promising Scaffold With Calcium Channel Blocking Activity

Drug Development Research, Volume 87, Issue 2, April 2026.
ABSTRACT Hexahydroquinoline (HHQ) is a widely recognized scaffold that has garnered considerable attention owing to its diverse pharmacological properties. The structure of HHQ includes a 1,4‐dihydropyridine (DHP) ring, which serves as the pharmacophore for the predominant class of drugs known as calcium channel blockers.
Ebru Koçak Aslan, Kevin Lam, Sun Huang, Göknil Pelin Coşkun, Ayşe Karagüzel, Katrin Denzinger, Kaan Birgül, Mert Ülgen, Jordan W. Nafie, Onur Şahin, Daniel W. Armstrong, Gerald W. Zamponi, Gerhard Wolber, Miyase Gözde Gündüz   +13 more
wiley   +1 more source

Oxidation of Hantzsch 1,4- Dihydropyridines to Pyridines with Thallium Triacetate [PDF]

Iranian Journal of Chemistry & Chemical Engineering, 2003
Hantzsch 1, 4-dihydropyridines (1,4-DHPs) can be oxidized to the corresponding pyridine derivatives by thallium triacetate in high yields.
Mohammad Mahmoodi Hashemi, Mohammad Sadegh Zakeri, Saeed Arianfar   +2 more
doaj  

Microwave‐Assisted Organic Syntheses in Deep Eutectic Solvents: A Win‐Win Association for Sustainable Chemistry

ChemistryOpen, Volume 15, Issue 4, April 2026.
In organic synthesis, deep eutectic solvents (DES) have demonstrated their ability to be used as reaction media for the development of reactions in line with green chemistry principles. This review presents an overview of microwave‐assisted organic synthesis in DES, highlighting the diversity of uses for these solvents, their role in mechanisms, the ...
Pierre‐Olivier Delaye, Chefikou Salami, Emilie Thiery   +2 more
wiley   +1 more source