Results 71 to 80 of about 146,224 (211)

Hexahydroquinoline Featuring Amide Functionality: A Promising Scaffold With Calcium Channel Blocking Activity

Drug Development Research, Volume 87, Issue 2, April 2026.
ABSTRACT Hexahydroquinoline (HHQ) is a widely recognized scaffold that has garnered considerable attention owing to its diverse pharmacological properties. The structure of HHQ includes a 1,4‐dihydropyridine (DHP) ring, which serves as the pharmacophore for the predominant class of drugs known as calcium channel blockers.
Ebru Koçak Aslan, Kevin Lam, Sun Huang, Göknil Pelin Coşkun, Ayşe Karagüzel, Katrin Denzinger, Kaan Birgül, Mert Ülgen, Jordan W. Nafie, Onur Şahin, Daniel W. Armstrong, Gerald W. Zamponi, Gerhard Wolber, Miyase Gözde Gündüz   +13 more
wiley   +1 more source

Sodium Hypochlorite-Dowex 1X8-200: A Convenient Oxidizing Reagant [PDF]

Iranian Journal of Chemistry & Chemical Engineering, 2002
The polymer supported hypochlorite ion is a facile selective oxidizing agent for the oxidation of various alcohols to aldehydes and ketones. Similarly is successfully oxidizes various Hantzsch type 1,4- dihydropyridines to corresponding pyridines.
Mahammad Mahmoodi Hashemi, Yousef Ahmadibeni   +1 more
doaj  

Design and synthesis of novel 4-substituted 1,4-dihydropyridine derivatives as hypotensive agents

Journal of Saudi Chemical Society, 2016
Calcium-channel blockers have an important role in the treatment of several cardiovascular disorders. Derivatives of 1,4-dihydropyridines are one of the most potent calcium antagonists.
Prasanna A. Datar, Pratibha B. Auti
doaj   +1 more source

Synthesis, spectroscopic characterization, X-ray structure, and DFT calculations of some new 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxamides. [PDF]

PLoS ONE, 2014
A series of novel 1,4-dihydro-2,6- dimethyl-3,5-pyridinedicarboxamides were synthesized and characterized by infrared absorption spectrum (IR), proton nuclear magnetic resonance (1H NMR), elemental analysis, ultraviolet spectrum (UV), and fluorescence ...
Yi Li, Yuan-Yuan Liu, Xue-Jun Chen, Xiao-Hui Xiong, Fang-Shi Li   +4 more
doaj   +1 more source

Microwave‐Assisted Organic Syntheses in Deep Eutectic Solvents: A Win‐Win Association for Sustainable Chemistry

ChemistryOpen, Volume 15, Issue 4, April 2026.
In organic synthesis, deep eutectic solvents (DES) have demonstrated their ability to be used as reaction media for the development of reactions in line with green chemistry principles. This review presents an overview of microwave‐assisted organic synthesis in DES, highlighting the diversity of uses for these solvents, their role in mechanisms, the ...
Pierre‐Olivier Delaye, Chefikou Salami, Emilie Thiery   +2 more
wiley   +1 more source

Oxidative aromatization of Hantzsch 1,4-dihydropyridines by sodium chlorite

, 2010
Hantzsch 1,4-dihydropyridines were converted to the corresponding pyridines efficiently by sodium chlorite under mild conditions in excellent yields. (C) 2010 Elsevier Ltd.
Lin, Wenbin, Liao, Xiali, Lu, Jun, Wang, C, Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Peoples R China, Wang, Chun   +4 more
core  

The accelerated preparation of 1,4-dihydropyridines using microflow reactors

, 2014
The synthesis of 1,4-dihydropyridines was performed in a continuous-flow microreactor. Elevated temperatures accelerated the reaction rate significantly allowing the reaction to be finished in minutes (6–11 min).
Timothy Noel, Baraldi, Patricia Tambarussi, Hessel, Volker, Patricia Tambarussi Baraldi, Wang, Q., Tambarussi Baraldi, P., Wang, Qi, Volker Hessel, Noel, T., Qi Wang, Noël, Timothy, Hessel, V.   +11 more
core   +1 more source

Bis‐Furans: A Sustainable Source of Diverse Molecular Architectures

European Journal of Organic Chemistry, Volume 29, Issue 10, 9 March 2026.
A concise synthetic route to diverse acyclic and heterocyclic compounds has been developed by combining hetero‐Diels–Alder reactions, DBU‐promoted ring openings, and Lewis base‐catalyzed annulations. Nitrosoalkenes reacted with furan derivatives to form 4a,7a‐dihydro‐4H‐furo[2,3‐e][1,2]oxazines, which underwent DBU‐promoted rearrangements to 6H‐1,2 ...
Ana L. Cardoso, José A. Paixão, Teresa M. V. D. Pinho e Melo   +2 more
wiley   +1 more source

Nucleophilic dearomatization of 4-aza-6-nitrobenzofuroxan by CH acids in the synthesis of pharmacology-oriented compounds

Beilstein Journal of Organic Chemistry, 2017
4-Aza-6-nitrobenzofuroxan (ANBF) reacts with 1,3-dicarbonyl compounds and other CH acids to give carbon-bonded 1,4-adducts – 1,4-dihydropyridines fused with furoxan ring.
Alexey M. Starosotnikov, Dmitry V. Shkaev, Maxim A. Bastrakov, Ivan V. Fedyanin, Svyatoslav A. Shevelev, Igor L. Dalinger   +5 more
doaj   +1 more source

Photodecomposition of a New 1,4-Dihydropyridine: Furnidipine

Journal of Pharmaceutical Sciences, 1994
The photodecomposition of new 1,4-dihydropyridine, furnidipine (CRE-319); [2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-tetrahydrofurfuryl 5-methyl diester) was studied by voltammetric, UV-vis spectrophotometric, and HPLC technique with three different light conditions (artificial daylight, UV light, and room daylight ...
Núñez Vergara, Luis, Sunkel, Carlos, Squella Serrano, Juan   +2 more
openaire   +3 more sources