Results 11 to 20 of about 116,777 (208)

Acyl-1,4-Dihydropyridines: Universal Acylation Reagents for Organic Synthesis [PDF]

Molecules
Acyl-1,4-dihydropyridines have recently emerged as universal acylation reagents. These easy-to-make and bench-stable NADH biomimetics play the dual role of single-electron reductants and sources of acyl radicals.
Karthikeyan Manoharan, Bartosz Bieszczad
doaj   +3 more sources

Antimicrobial Activity of Some Derivatives of 1,4-Dihydropyridines [PDF]

Journal of Chemistry, 2013
Hantzsch reported the synthesis of functionalized 1,4-dihydropyridines via three-component condensation of an aromatic aldehyde, ketoester, and ammonium hydroxide.
Prabha Mehta, Prabha Verma
doaj   +3 more sources

Antileishmanial and Antitoxoplasmal Activities of 1,4-Dihydropyridines [PDF]

ACS Omega
We have synthesized 24 1,4-dihydropyridine compounds (1,4-DHPs) with different substituents at the aromatic ring by microwave-assisted one-pot Hantzsch multicomponent reaction and evaluated their in vitro activities against Toxoplasma gondii and Leishmania major. We have found that compound 9 ((±)-ethyl 2,7,7-trimethyl-4-(2-nitrophenyl)-5-oxo-1,4,5,6,7,
Thaís A. S. Oliveira, Yan R. Robles, Ibrahim S. Al Nasr, Waleed S. Koko, Tariq A. Khan, Ismail Daoud, Seyfeddine Rahali, Noureddine Amdouni, Ridha B. Said, Antônio E. M. Crotti   +9 more
doaj   +4 more sources

Data for the synthesis and characterisation of 2,6-di(bromomethyl)-3,5-bis(alkoxycarbonyl)-4-aryl-1,4-dihydropyridines as important intermediates for synthesis of amphiphilic 1,4-dihydropyridines [PDF]

Data in Brief, 2020
This data file describes the synthetic protocol for preparation of the original 2,6-di(bromomethyl)-3,5-bis(alkoxycarbonyl)-4-aryl-1,4-dihydropyridines. In total, 6 unpublished compounds were obtained and characterised.
Martins Rucins, Klavs Pajuste, Arkadij Sobolev, Mara Plotniece, Nadiia Pikun, Karlis Pajuste, Aiva Plotniece   +6 more
doaj   +2 more sources

Four-Component Fusion Protocol with NiO/ZrO₂ as a Robust Recyclable Catalyst for Novel 1,4-Dihydropyridines [PDF]

ACS Omega, 2019
Nickel oxide loaded on zirconia (NiO/ZrO2) as an expedient catalyst is reported for the synthesis of 18 unsymmetrical 1,4-dihydropyridine derivatives.
Werner E. van Zyl (2966031), Suresh Maddila (578307), Sandeep V.H.S. Bhaskaruni (8086226), Sreekantha B. Jonnalagadda (8086229)   +3 more
core   +4 more sources

Ammonium metavanadate (NH4VO3): a highly efficient and eco-friendly catalyst for one-pot synthesis of pyridines and 1,4-dihydropyridines [PDF]

Scientific Reports, 2022
In this study, we reported the ammonium metavanadate (NH4VO3) as an efficient, cost-effective, and mild catalyst for the synthesis of substituted pyridines via a one-pot pseudo four-component reaction.
Jamal Rahimi, Maryam Niksefat, Marzieh Heidari, Mehdi Naderi, Hadis Abbasi, Mohammad Tajik Ijdani, Ali Maleki   +6 more
doaj   +2 more sources

Anticancer Activity of 4-Aryl-1,4-Dihydropyridines

Future Pharmacology
We have synthesized 22 symmetric and asymmetric 4-aryl-1,4-dihydropyridines (1,4-DHPs) by a “green” microwave-assisted one-pot multicomponent Hantzsch reaction and evaluated their cytotoxicity to three human cancer cell lines regarding U-251MG (human ...
Thaís A. S. Oliveira, Jackson B. A. Silva, Tábata R. Esperandim, Nathália O. Acésio, Denise C. Tavares, Antônio E. M. Crotti   +5 more
doaj   +3 more sources

Recent Approaches to Chiral 1,4-Dihydropyridines and their Fused Analogues

Catalysts, 2020
The purpose of this review is to highlight recent developments in the synthesis of chiral 1,4-dihydropyridines and their fused analogues. 1,4-Dihydropyridines are among the most active calcium antagonists that are used for the treatment of hypertension ...
Martins Rucins, Aiva Plotniece, Eiva Bernotiene   +2 more
exaly   +2 more sources

Efficient One-Pot Synthesis of 1,4-Dihydropyridines Catalyzed by Magnetic MnFe2O4 Nanoparticles

Acta Chimica Slovenica, 2022
The efficient one-pot synthesis of some 1,4-dihydropyridines is described by a condensation reaction of some aldehyde derivatives, ethyl acetoacetate and ammonium acetate in the presence of superparamagnetic manganese ferrite nanoparticles at 80 °C.
Somayeh Moradi, Mohsen Moradian, Hossein Naeimi   +2 more
doaj   +3 more sources

Synthesis of Indenones via Persulfate Promoted Radical Alkylation/Cyclization of Biaryl Ynones with 1,4-Dihydropyridines [PDF]

Molecules
The oxidative radical cascade cyclization of alkynes has emerged as a versatile strategy for the efficient construction of diverse structural units and complex molecules in organic chemistry.
Wanwan Wang, Lei Yu
doaj   +2 more sources