Results 101 to 110 of about 3,255 (160)

mutation blocks ABA signaling downstream of cADPR action

, 2003
Arabidopsis thaliana abscisic acid insensitive 1-1 (abi1-1) is a dominant mutant that is insensitive to the inhibition of germination and growth by the plant hormone, abscisic acid (ABA). The mutation severely decreases the catalytic activity of the ABI1
Yan Wu, Himmelbach, Axel, Juan Pablo Sanchez, Chua, Nam-Hai, Nam‐Hai Chua, Wu, Yan, Sanchez, Juan Pablo, Grill, Erwin, Erwin Grill, Luis Lopez‐Molina, Lopez Molina, Luis, Axel Himmelbach   +11 more
core   +1 more source

ABA- and cADPR-mediated effects on respiration and filtration downstream of the temperature-signaling cascade in sponges.

, 2003
Recently, the thermosensing pathway in sponges (Porifera) was elucidated. The thermosensor triggering this cascade is a heat-activated cation channel, with the phytohormone abscisic acid (ABA), cyclic ADP-ribose (cADPR) and calcium acting as ...
Bavestrello G, Guida L, Basile G, Giovine M, Usai C, Zocchi E, Cerrano C, Carpaneto A, Bruzzone S, Magrassi R   +9 more
core  

Gap junction intercellular communications regulates activation of SARM1 and protects against axonal degeneration

Cell Death and Disease
Sterile alpha and Toll/interleukin-1 receptor motif containing 1 (SARM1), a nicotinamide adenine dinucleotide (NAD)-utilizing enzyme, mediates axon degeneration (AxD) in various neurodegenerative diseases.
Wen Jie Zhu, Jun Liu, Wan Hua Li, Zhi Ying Zhao, Chongquan Huang, Jian Yuan Yang, Hon Cheung Lee, Yong Juan Zhao   +7 more
doaj   +1 more source

Macrophage SELENOP controls neutrophil homeostasis through redox stress regulation in Crohn's disease. [PDF]

Redox Biol
Wang H, Wang J, Jiang W, Cheng C, Cheng S, Fu S, Zhang Y, Liu C, Sun J, Zhao J.   +9 more
europepmc   +1 more source

Modulating CD38 enzymatic activity during antibody-based immunotherapy in multiple myeloma: a basic science perspective. [PDF]

Front Immunol
Horenstein AL, Frerichs KA, Faini AC, van de Donk NWCJ, Malavasi F.   +4 more
europepmc   +1 more source

The role of dietary niacin intake and the ADP-ribosyl cyclase enzyme CD38 in spatial learning and memory: Is cADPR the link between diet and behavior?

, 2007
This thesis is an investigation of the role of dietary niacin and the ADP-ribosyl cyclase enzyme CD38 in spatial learning and memory in rodents. CD38 catalyzes the formation of cyclic ADP-ribose (cADPR) from NAD +, which is derived from dietary niacin ...
Young, Genevieve Sarah
core  

Mitochondrial dysfunction induced by a cytotoxic adenine dinucleotide produced by ADP-ribosyl cyclases from cADPR

, 2007
ADP-ribosyl cyclases were previously shown to produce three new adenine dinucleotides, P1,P2 diadenosine 5'-diphosphate (Ap2A) and two isomers thereof (P18 and P24), from cyclic ADP-ribose (cADPR) and adenine (Basile, G., Taglialatela-Scafati, O ...
BRUZZONE S, DE FLORA A, DI LISA, FABIO, BASILE G, ZOCCHI E., DODONI G, MILLO E, KALUDERCIC, NINA   +7 more
core  

The Great Potential of the Cluster of Differentiation 38 (CD38) Inhibitors in the Treatment of Cancer and Age-Related Metabolic dysfunction. [PDF]

ACS Med Chem Lett
Abdel-Magid AF.
europepmc   +1 more source

Direct activation of SARM1 by dsDNA is not supported by biochemical and cellular evidence. [PDF]

Proc Natl Acad Sci U S A
Kao AH, Mishra BP, Sorbello M, Zhang W, Zhou Q, Jiang Y, Masic V, Harten P, Gu W, Yang JY, Bloom AJ, Mitra RD, Zhang Z, Zhao YJ, Orsomando G, Wang X, Milbrandt J, Kobe B, Ve T, DiAntonio A.   +19 more
europepmc   +1 more source

Macrophage metabolic exhaustion and PANoptotic cell death drive chronic tissue inflammation in rheumatoid arthritis. [PDF]

Immunity
Huang T, Takashima Y, Kumar J, Morales J, Le K, Hu Z, Rubino S, Trousdale RT, Berry GJ, Goronzy JJ, Weyand CM.   +10 more
europepmc   +1 more source