Results 31 to 40 of about 3,255 (160)

O6-[(2″,3″-O-Isopropylidene-5″-O-^tbutyldimethylsilyl)pentyl]-5′-O-^tbutyldiphenylsilyl-2′,3′-O-isopropylideneinosine

Molbank, 2022
Cyclic adenosine diphosphate ribose (cADPR) is a cyclic nucleotide involved in the Ca2+ homeostasis. In its structure, the northern ribose, bonded to adenosine through an N1 glycosidic bond, is connected to the southern ribose through a pyrophosphate ...
Maria Marzano, Monica Terracciano, Vincenzo Piccialli, Ahmed Mahal, Roberto Nilo, Stefano D’Errico   +5 more
doaj   +1 more source

Paracrine ADP Ribosyl Cyclase-Mediated Regulation of Biological Processes

Cells, 2022
ADP-ribosyl cyclases (ADPRCs) catalyze the synthesis of the Ca2+-active second messengers Cyclic ADP-ribose (cADPR) and ADP-ribose (ADPR) from NAD+ as well as nicotinic acid adenine dinucleotide phosphate (NAADP+) from NADP+. The best characterized ADPRC
Cecilia Astigiano, Andrea Benzi, Maria Elena Laugieri, Francesco Piacente, Laura Sturla, Lucrezia Guida, Santina Bruzzone, Antonio De Flora   +7 more
doaj   +1 more source

The Identification of a Novel Calcium-Dependent Link Between NAD+ and Glucose Deprivation-Induced Increases in Protein O-GlcNAcylation and ER Stress

Frontiers in Molecular Biosciences, 2021
The modification of proteins by O-linked β-N-acetylglucosamine (O-GlcNAc) is associated with the regulation of numerous cellular processes. Despite the importance of O-GlcNAc in mediating cellular function our understanding of the mechanisms that ...
Luyun Zou, Helen E. Collins, Martin E. Young, Jianhua Zhang, Jianhua Zhang, Adam R. Wende, Victor M. Darley-Usmar, John C. Chatham   +7 more
doaj   +1 more source

Essential role of CD38 in platelet aggregation through the PKC- mediated internalization and activation [PDF]

BioImpacts
Introduction: CD38 is a multifunctional enzyme with a potent Ca2+ mobilizing effect, cyclic ADP-ribose (cADPR), and nicotinic acid adenine dinucleotide phosphate (NAADP).
Mazhar Mushtaq, Maira Mahmood, Uzma Jabbar, Uh-Hyun Kim   +3 more
doaj   +1 more source

cADPR stimulates SERCA activity in Xenopus oocytes.

, 2009
The intracellular second messenger cyclic ADP-ribose (cADPR) induces Ca(2+) release through the activation of ryanodine receptors (RyRs). Moreover, it has been suggested that cADPR may serve an additional role to modulate sarco/endoplasmic reticulum Ca(2+
Yamasaki-Mann, M, Yamasaki-Mann, Michiko, Demuro, A, Parker, I   +3 more
core   +1 more source

A Cell-Permeant Mimetic of NMN Activates SARM1 to Produce Cyclic ADP-Ribose and Induce Non-apoptotic Cell Death

iScience, 2019
Summary: SARM1, an NAD-utilizing enzyme, regulates axonal degeneration. We show that CZ-48, a cell-permeant mimetic of NMN, activated SARM1 in vitro and in cellulo to cyclize NAD and produce a Ca2+ messenger, cADPR, with similar efficiency as NMN ...
Zhi Ying Zhao, Xu Jie Xie, Wan Hua Li, Jun Liu, Zhe Chen, Ben Zhang, Ting Li, Song Lu Li, Jun Gang Lu, Liangren Zhang, Li-he Zhang, Zhengshuang Xu, Hon Cheung Lee, Yong Juan Zhao   +13 more
doaj   +1 more source

The Arabidopsis circadian clock incorporates a cADPR-based feedback loop

, 2007
peer reviewedTranscriptional feedback loops are a feature of circadian clocks in both animals and plants. We show that the plant circadian clock also incorporates the cytosolic signaling molecule cyclic adenosine diphosphate ribose (cADPR).
Hubbard, Katharine E., Dodd, A, Dalchau, N., Webb, A. A. R., Love, J., Robertson, Fiona C., GONCALVES, Jorge, Assie, Jean-Maurice, Jakobsen, M, Dodd, A. N., Gardner, M. J., Sanders, D, Dodd, AN, Webb, Alex A. R., Gardner, MJ, Goncalves, J, Hotta, C, Robertson, FC, Webb, AAR, Hotta, Carlos T., Dalchau, Neil, Love, John, Goncalves, JM, Robertson, F. C., Sanders, Dale, Dodd, Antony N., ,, Hotta, CT, Dalchau, N, Hubbard, K, Hotta, C. T., Assie, JM, Gardner, M, Robertson, F, Jakobsen, M. K., Gardner, Michael J., Love, J, Jakobsen, Mia Kyed, Webb, A, Hubbard, KE, Hubbard, K. E., Jakobsen, MK, Sanders, D., Assie, J. M.   +43 more
core   +1 more source

Cyclic ADP-ribose and heat regulate oxytocin release via CD38 and TRPM2 in the hypothalamus during social or psychological stress in mice

Frontiers in Neuroscience, 2016
Hypothalamic oxytocin (OT) is released into the brain by cyclic ADP-ribose (cADPR) with or without depolarizing stimulation. Previously, we showed that the intracellular free calcium concentration ([Ca2+]i) that seems to trigger OT release can be ...
Jing Zhong, Sarwat Amina, Mingkun Liang, Shirin Akther, Teruko Yuhi, Tomoko Nishimura, Chiharu Higashida, Takahiro Tsuji, Hong-Xiang Liu, Minako Hashii, Kazumi Furuhara, Shigeru Yokoyama, Yasuhiko Yamamoto, Hiroshi Okamoto, Yong Juan Zhao, Hon Cheung Lee, Makoto Tominaga, Olga Lopatina, Haruhiro Higashida   +18 more
doaj   +1 more source

Insights into the mechanism of bovine CD38/NAD+glycohydrolase from the X-ray structures of its Michaelis complex and covalently-trapped intermediates. [PDF]

PLoS ONE, 2012
Bovine CD38/NAD(+)glycohydrolase (bCD38) catalyses the hydrolysis of NAD(+) into nicotinamide and ADP-ribose and the formation of cyclic ADP-ribose (cADPR).
Pascal F Egea, Hélène Muller-Steffner, Isabelle Kuhn, Céline Cakir-Kiefer, Norman J Oppenheimer, Robert M Stroud, Esther Kellenberger, Francis Schuber   +7 more
doaj   +1 more source

Calmodulin dissociation mediates desensitization of the cADPR-induced Ca2+ release mechanism. [PDF]

, 2002
Ryanodine receptor (RyR) activation by cyclic ADP-ribose (cADPR) is followed by homologous desensitization. Though poorly understood, this "switching off" process has provided a key experimental tool for determining the pathway through which cADPR ...
Fruen, Bradley R., Churchill, GC, Thomas, JM, Thomas, Justyn M., Summerhill, RJ, Fruen, BR, Churchill, Grant C., Summerhill, Robin J., Churchill, Grant, Galione, A, Galione, Antony   +10 more
core   +1 more source