Results 11 to 20 of about 3,255 (160)

CD38-cADPR-SERCA Signaling Axis Determines Skeletal Muscle Contractile Force in Response to β-Adrenergic Stimulation

Cellular Physiology and Biochemistry, 2018
Background/Aims: Cyclic ADP-ribose (cADPR) is a Ca2+ -mobilization messenger that acts on ryanodine-sensitive Ca2+ channels in the sarcoplasmic reticulum (SR) Ca2+ stores.
Dae-Ryoung Park, Tae-Sik Nam, Ye-Won Kim, Seo-Ho Lee, Uh-Hyun Kim   +4 more
doaj   +3 more sources

Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) and Cyclic ADP-Ribose (cADPR) Mediate Ca2+ Signaling in Cardiac Hypertrophy Induced by β-Adrenergic Stimulation. [PDF]

PLoS ONE, 2016
Ca2+ signaling plays a fundamental role in cardiac hypertrophic remodeling, but the underlying mechanisms remain poorly understood. We investigated the role of Ca2+-mobilizing second messengers, NAADP and cADPR, in the cardiac hypertrophy induced by β ...
Rukhsana Gul, Dae-Ryoung Park, Asif Iqbal Shawl, Soo-Yeul Im, Tae-Sik Nam, Sun-Hwa Lee, Jae-Ki Ko, Kyu Yoon Jang, Donghee Kim, Uh-Hyun Kim   +9 more
doaj   +2 more sources

Interactions between intracellular Ca2+ stores: Ca2+ released from the NAADP pool potentiates cADPR-induced Ca2+ release

Brazilian Journal of Medical and Biological Research, 2002
Cells possess multiple intracellular Ca2+-releasing systems. Sea urchin egg homogenates are a well-established model to study intracellular Ca2+ release. In the present study the mechanism of interaction between three intracellular Ca2+ pools, namely the
E.N. Chini
doaj   +2 more sources

Arginine Thiazolidine Carboxylate Stimulates Insulin Secretion through Production of Ca2+-Mobilizing Second Messengers NAADP and cADPR in Pancreatic Islets. [PDF]

PLoS ONE, 2015
Oxothiazolidine carboxylic acid is a prodrug of cysteine that acts as an anti-diabetic agent via insulin secretion and the formation of the Ca2+-mobilizing second messenger, cyclic ADP-ribose (cADPR).
Dae-Ryoung Park, Asif Iqbal Shawl, Tae-Geun Ha, Kwang-Hyun Park, Seon-Young Kim, Uh-Hyun Kim   +5 more
doaj   +2 more sources

TPI1 Loss Triggers a Metabolite-Driven Mitochondrial Redox Vulnerability via the SARM1-cADPR-Ca²⁺ Axis. [PDF]

Adv Sci (Weinh)
Metabolite‐driven redox stress governs cancer cell senescence. TPI1 deficiency elevates DHAP, initiating SARM1‐dependent cADPR‐Ca2+ release. Mitochondrial ROS surge subsequently induces DNA damage and senescence, offering a conserved therapeutic target in multiple cancers.
Liu C, Wu S, Wang C, Zhou Z, Cai T, Tao W, Zuo S, Zhang C, Dong Y, Feng Y, Huang Q, Wang B, Ma X, Ma H, Zhang X, Huang Y.   +15 more
europepmc   +2 more sources

Quantification of SARM1 NADase Activity in Human Peripheral Blood Mononuclear Cells. [PDF]

FASEB J
Proposed model for NAD+ metabolism in (A) control and (B) SARM1 activated PBMCs. In native form, 3‐AP and Vacor compete with NAM as an alternative substrate for NAMPT. This consequently decreases generation of NMN and biosynthesis of NAD+ is limited by both a reduction in precursor NMN and direct inhibition of NMNAT by Vacor‐MN and 3‐AP‐MN.
Dabill LF, Shen IR, Brazill JM, Neiner A, Sasaki Y, Scheller EL.   +5 more
europepmc   +2 more sources

Type III CD38 is present in the membrane of neurosecretory vesicles and has a cytosol-facing catalytic domain in primate oxytocin neurons. [PDF]

J Neuroendocrinol
Abstract CD38, an ADP‐ribosyl cyclase that generates cyclic ADP‐ribose (cADPR), is essential for Ca2+‐dependent oxytocin release. However, its subcellular localisation and membrane topology within oxytocin neurones have remained unclear. We investigated the distribution and orientation of CD38 in oxytocin‐producing neurones of Japanese macaques (Macaca
Miyamoto T, Matsushima A, Otubo A, Song C, Murata K, Oti T, Sakamoto H.   +6 more
europepmc   +2 more sources

Molecular mechanisms of plant NLR activation and signalling. [PDF]

Plant J
SUMMARY Plants rely on NLRs (nucleotide‐binding leucine‐rich repeat receptors) to recognise effector proteins secreted by pathogens into plant cells and to deliver disease resistance. Plant NLRs are broadly characterised by their N‐terminal domains, which include the TIR (Toll/interleukin‐1 receptor) and the CC (coiled‐coil) domains.
Maruta N, Sorbello M, Garzon-Flores L, Kobe B.   +3 more
europepmc   +2 more sources

cADPR Does Not Activate TRPM2

, 2022
cADPR is a second messenger that releases Ca2+ from intracellular stores via the ryanodine receptor. Over more than 15 years, it has been controversially discussed whether cADPR also contributes to the activation of the nucleotide-gated cation channel ...
Andreas Bauche, Andreas H. Guse, Simon Sander, Henning Tidow, Ralf Fliegert, Winnie Maria Riekehr, Jelena Pick   +6 more
core   +1 more source

Cyclic ADP-Ribose Mediates Formyl Methionyl Leucyl Phenylalanine (fMLP)-Induced Intracellular Ca2+Rise and Migration of Human Neutrophils

Journal of Pharmacological Sciences, 2008
Although cyclic ADP-ribose (cADPR), a novel Ca2+-mobilizing mediator, is suggested to be involved in the functions of neutrophils in rodents, its role in human neutrophils remains unclear.
Katsuya Morita, Minoru Saida, Norimitsu Morioka, Tomoya Kitayama, Yasumasa Akagawa, Toshihiro Dohi   +5 more
doaj   +1 more source