Results 31 to 40 of about 1,793 (129)

Arginine Thiazolidine Carboxylate Stimulates Insulin Secretion through Production of Ca2+-Mobilizing Second Messengers NAADP and cADPR in Pancreatic Islets. [PDF]

PLoS ONE, 2015
Oxothiazolidine carboxylic acid is a prodrug of cysteine that acts as an anti-diabetic agent via insulin secretion and the formation of the Ca2+-mobilizing second messenger, cyclic ADP-ribose (cADPR).
Dae-Ryoung Park, Asif Iqbal Shawl, Tae-Geun Ha, Kwang-Hyun Park, Seon-Young Kim, Uh-Hyun Kim   +5 more
doaj   +1 more source

Synthesis of a Stable Long-Wavelength Fluorescent BODIPY FL-NAADP Conjugate

Molbank
Nicotinic acid adenine dinucleotide phosphate (NAADP) is a second messenger that stimulates intracellular Ca2+ release in both mammalian cells and echinoderm egg homogenates.
Zhong Guan, James T. Slama
doaj   +1 more source

Activity of ATPases in postmitichondtial fraction of lymphoma NK/Ly cells under bafilomicine and NAADP presence

Біологічні студії, 2015
The system of active of transport of ions (ATPases) plays a critical role in cancer cells and is a potential target of anticancer therapy. A selective V-type H+-ATPase inhibitor – bafilomicine (Baf1A) was intensively studied as anticancer drug.
S. Bychkova, V. Hreniuh
doaj   +1 more source

Pharmacological inhibition of lysosomal two-pore channel 2 (TPC2) confers neuroprotection in stroke via autophagy regulation

Neurobiology of Disease, 2023
Lysosomal function and organellar Ca2+ homeostasis become dysfunctional in Stroke causing disturbances in autophagy, the major process for the degradation of abnormal protein aggregates and dysfunctional organelles.
Valentina Tedeschi, Antonio Vinciguerra, Maria Josè Sisalli, Giuseppe Pignataro, Agnese Secondo   +4 more
doaj   +1 more source

An Endosomal NAADP-Sensitive Two-Pore Ca2+ Channel Regulates ER-Endosome Membrane Contact Sites to Control Growth Factor Signaling

Cell Reports, 2017
Membrane contact sites are regions of close apposition between organelles that facilitate information transfer. Here, we reveal an essential role for Ca2+ derived from the endo-lysosomal system in maintaining contact between endosomes and the endoplasmic
Bethan S. Kilpatrick, Emily R. Eden, Leanne N. Hockey, Elizabeth Yates, Clare E. Futter, Sandip Patel   +5 more
doaj   +1 more source

Effects of Apocynin, a NADPH Oxidase Inhibitor, in the Protection of the Heart from Ischemia/Reperfusion Injury

Pharmaceuticals, 2023
Ischemia and perfusion (I/R) induce inflammation and oxidative stress, which play a notable role in tissue damage. The aim of this study was to investigate the role of an NADPH oxidase inhibitor (apocynin) in the protection of the heart from I/R injury ...
Ali Mohammad, Fawzi Babiker, Maie Al-Bader   +2 more
doaj   +1 more source

From Defense to Disease: NADPH Oxidase in Cellular Function and Dysregulation

Journal of Immunology Research, Volume 2026, Issue 1, 2026.
Nicotinamide adenine dinucleotide phosphate hydrogen (NADPH) oxidase is an important family of enzymes that produce reactive oxygen species (ROS) and consists of NOX1‐5, DUOX1, and DUOX2. These enzymes exhibit diverse tissue distributions with different activation mechanisms involved.
Ankush Prasad, Renu Kushwaha, Phaniendra Alugoju, Pavel Pospíšil, Deepak Rathi, Poorani Gurumallesh Prabu   +5 more
wiley   +1 more source

The Role of Two-Pore Channels in Norepinephrine-Induced [Ca²⁺]_i Rise in Rat Aortic Smooth Muscle Cells and Aorta Contraction

Cells, 2019
Second messenger nicotinic acid adenine dinucleotide phosphate (NAADP) triggers Ca2+ release via two-pore channels (TPCs) localized in endolysosomal vesicles. The aim of the present work is to evaluate the role of TPCs in the action of norepinephrine (NE)
Sergei K. Trufanov, Elena Yu. Rybakova, Piotr P. Avdonin, Alexandra A. Tsitrina, Irina L. Zharkikh, Nikolay V. Goncharov, Richard O. Jenkins, Pavel V. Avdonin   +7 more
doaj   +1 more source

Essential role of CD38 in platelet aggregation through the PKC- mediated internalization and activation [PDF]

BioImpacts
Introduction: CD38 is a multifunctional enzyme with a potent Ca2+ mobilizing effect, cyclic ADP-ribose (cADPR), and nicotinic acid adenine dinucleotide phosphate (NAADP).
Mazhar Mushtaq, Maira Mahmood, Uzma Jabbar, Uh-Hyun Kim   +3 more
doaj   +1 more source

Cross-talk between CD38 and TTP Is Essential for Resolution of Inflammation during Microbial Sepsis

Cell Reports, 2020
Summary: The resolution phase of acute inflammation is essential for tissue homeostasis, yet the underlying mechanisms remain unclear. We demonstrate that resolution of inflammation involves interactions between CD38 and tristetraprolin (TTP). During the
Yeonsoo Joe, Yingqing Chen, Jeongmin Park, Hyo Jeong Kim, So-Young Rah, Jinhyun Ryu, Gyeong Jae Cho, Hye-Seon Choi, Stefan W. Ryter, Jeong Woo Park, Uh-Hyun Kim, Hun Taeg Chung   +11 more
doaj   +1 more source